{"public_id":"cl_16416218cf0af7780e9fa67aa324630a","status":"active","superseded_by_public_id":null,"corpus_id":85053643,"text":"Phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-monophosphate are the most potent lipid activators of GRK2 and uniquely regulate it in a complex biphasic manner.","confidence":0.93,"paper":{"corpus_id":85053643,"title":"G Protein-coupled Receptor Kinase GRK2 Is a Phospholipid-dependent Enzyme That Can Be Conditionally Activated by G Protein βγ Subunits*","url":"https://sah.borca.ai/papers/85053643"},"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.93,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_1c9bcf9d635ceec9f5671e9410cba670","name":"phosphatidylinositol 4,5-bisphosphate","description":"A phosphoinositide lipid that modulates GRK2 activity and participates in biphasic regulation.","types":["lipid","phosphoinositide"],"url":"https://sah.borca.ai/concepts/co_1c9bcf9d635ceec9f5671e9410cba670"},{"public_id":"co_7373f3d9eef3a8035f892683e13c5c3a","name":"phosphatidylinositol 4-monophosphate","description":"A monophosphorylated phosphatidylinositol lipid tested as a regulator of GRK2 activity.","types":["lipid","phosphoinositide"],"url":"https://sah.borca.ai/concepts/co_7373f3d9eef3a8035f892683e13c5c3a"},{"public_id":"co_9784672a6bbfbe63cabbbfdbe03b67e2","name":"GRK2","description":"A G protein-coupled receptor kinase that phosphorylates receptors and is regulated by lipids and G protein subunits.","types":["enzyme","protein kinase"],"url":"https://sah.borca.ai/concepts/co_9784672a6bbfbe63cabbbfdbe03b67e2"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_16416218cf0af7780e9fa67aa324630a"}