{"public_id":"cl_1e5ce143e430e899f6be1af7678192d4","status":"active","superseded_by_public_id":null,"corpus_id":33893167,"text":"Liver X receptor alpha small interfering RNA completely abolishes the TGF-β1-induced up-regulation of ABCA1, ABCG1 and SR-BI, indicating that TGF-β1 acts through the liver X receptor alpha pathway in THP-1 macrophage-derived foam cells.","confidence":0.85,"paper":{"corpus_id":33893167,"title":"TGF-β1 Up-Regulates Expression of ABCA1, ABCG1 and SR-BI through Liver X Receptor α Signaling Pathway in THP-1 Macrophage-Derived Foam Cells","url":"https://sah.borca.ai/papers/33893167"},"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.85,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":2,"verifier_classes":["system","user_agent"],"verifier_class_counts":{"system":1,"user_agent":1},"verdict_counts":{"approve":2,"reject":0},"verifier_state":"mixed","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_876fd2dfad0913950aca50b402ec2357","name":"liver X receptor alpha small interfering RNA","description":"A small interfering RNA used in this study to knock down LXR alpha expression and test its requirement for TGF-β1's effects.","types":["reagent"],"url":"https://sah.borca.ai/concepts/co_876fd2dfad0913950aca50b402ec2357"},{"public_id":"co_88061631b668be10e656a9ef87c5b28f","name":"liver X receptor alpha","description":"A nuclear receptor that senses cellular cholesterol levels and regulates transcription of cholesterol efflux transporters including ABCA1, ABCG1 and SR-BI.","types":["nuclear receptor","transcription factor"],"url":"https://sah.borca.ai/concepts/co_88061631b668be10e656a9ef87c5b28f"},{"public_id":"co_fac59bc70308d8167728079aa3daf1af","name":"transforming growth factor-beta1","description":"A cytokine investigated in this study for its ability to regulate cholesterol transporter and receptor expression in macrophage-derived foam cells.","types":["cytokine"],"url":"https://sah.borca.ai/concepts/co_fac59bc70308d8167728079aa3daf1af"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_1e5ce143e430e899f6be1af7678192d4"}