{"public_id":"cl_3708a5864dbfa9fd8468e841c2ac37c3","status":"active","superseded_by_public_id":null,"corpus_id":51702450,"text":"Restoring miR-29b expression inhibits doxorubicin-induced myocardial apoptosis and is accompanied by increased Bcl-2 expression, decreased Bax expression, and reduced caspase-3 activity.","confidence":0.97,"paper":{"corpus_id":51702450,"title":"MicroRNA-29b Regulates the Mitochondria-Dependent Apoptotic Pathway by Targeting Bax in Doxorubicin Cardiotoxicity","url":"https://sah.borca.ai/papers/51702450"},"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.97,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_2ba91bd3d06ec7ff1cc7b789df5c93e9","name":"miR-29b","description":"A microRNA in the miR-29 family investigated as a regulator of cardiomyocyte apoptosis.","types":["microRNA"],"url":"https://sah.borca.ai/concepts/co_2ba91bd3d06ec7ff1cc7b789df5c93e9"},{"public_id":"co_557f07c2878028deeccc8ed5e57c1a9c","name":"Bcl-2","description":"An anti-apoptotic protein measured as part of the mitochondrial apoptosis pathway.","types":["protein"],"url":"https://sah.borca.ai/concepts/co_557f07c2878028deeccc8ed5e57c1a9c"},{"public_id":"co_66e7ddec0cf0df45b2e3689b2eef3643","name":"myocardial apoptosis","description":"Programmed cell death occurring in heart muscle cells.","types":["cell death process"],"url":"https://sah.borca.ai/concepts/co_66e7ddec0cf0df45b2e3689b2eef3643"},{"public_id":"co_6b75e59265b6eb5e8fd504d48883bcfc","name":"caspase-3","description":"An executioner caspase whose activity reflects apoptosis progression.","types":["protein"],"url":"https://sah.borca.ai/concepts/co_6b75e59265b6eb5e8fd504d48883bcfc"},{"public_id":"co_def72bbd4a00222d50c0935961284098","name":"Bax","description":"A pro-apoptotic Bcl-2 family protein targeted by miR-29b in the study.","types":["protein"],"url":"https://sah.borca.ai/concepts/co_def72bbd4a00222d50c0935961284098"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_3708a5864dbfa9fd8468e841c2ac37c3"}