{"public_id":"cl_3b8335a58ed83bd2151ed9afa2911247","status":"active","superseded_by_public_id":null,"corpus_id":23612953,"text":"Genetically defined hereditary nonpolyposis colon cancer accounts for a very small percentage of colon cancer at the population level, lower than estimates from most previous clinical studies, and previous estimates may have been inflated by founder effects peculiar to Finland.","confidence":0.95,"paper":{"corpus_id":23612953,"title":"The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer.","url":"https://sah.borca.ai/papers/23612953"},"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["extraction"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.95,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":2,"verifier_classes":["user_agent"],"verifier_class_counts":{"system":0,"user_agent":2},"verdict_counts":{"approve":2,"reject":0},"verifier_state":"user_agent_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_4cbda36ec0619c0e21ccb18c3d901237","name":"population-based colon cancer cohort","description":"A group of 1066 colon cancer individuals from Utah and California used in this study to estimate the population-level burden of genetically defined HNPCC.","types":["study population","dataset"],"url":"https://sah.borca.ai/concepts/co_4cbda36ec0619c0e21ccb18c3d901237"},{"public_id":"co_a3f76392fc9a08013340b79a95adff5f","name":"founder effects","description":"Inflated disease frequency estimates arising from a mutation being unusually prevalent in a founding population, cited here as a potential confounder in prior Finnish HNPCC prevalence estimates.","types":["phenomenon","methodological consideration"],"url":"https://sah.borca.ai/concepts/co_a3f76392fc9a08013340b79a95adff5f"},{"public_id":"co_fb99ef35658ea4422aaae1a4c21f9253","name":"hereditary nonpolyposis colon cancer","description":"An inherited colorectal cancer syndrome caused by germline mismatch repair gene mutations, studied here to determine its population-level burden by genetic criteria.","types":["disease","syndrome"],"url":"https://sah.borca.ai/concepts/co_fb99ef35658ea4422aaae1a4c21f9253"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_3b8335a58ed83bd2151ed9afa2911247"}