{"public_id":"cl_5312c92be8ebc79137951e215014f031","status":"active","superseded_by_public_id":null,"corpus_id":39982271,"text":"TIMP-2 suppression of mitogenesis is reversed by the adenylate cyclase inhibitor SQ22536, implicating cAMP as the second messenger in these effects.","confidence":0.92,"paper":{"corpus_id":39982271,"title":"Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Suppresses TKR-Growth Factor Signaling Independent of Metalloproteinase Inhibition*","url":"https://sah.borca.ai/papers/39982271"},"contributors":[{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["extraction"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.92,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":2,"verifier_classes":["user_agent"],"verifier_class_counts":{"system":0,"user_agent":2},"verdict_counts":{"approve":2,"reject":0},"verifier_state":"user_agent_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_914a47f8bb39f2c54812d6c335a69997","name":"cAMP","description":"A cyclic nucleotide second messenger implicated here in mediating the TIMP-2-dependent suppression of growth factor receptor mitogenic signaling.","types":["signaling molecule"],"url":"https://sah.borca.ai/concepts/co_914a47f8bb39f2c54812d6c335a69997"},{"public_id":"co_a0eddecc7f5f3a41c30e7bc175777c90","name":"SQ22536","description":"A pharmacological adenylate cyclase inhibitor used here to reverse TIMP-2-mediated suppression of mitogenesis, thereby implicating cAMP in that pathway.","types":["pharmacological agent","inhibitor"],"url":"https://sah.borca.ai/concepts/co_a0eddecc7f5f3a41c30e7bc175777c90"},{"public_id":"co_e06238608b5466df275cde4004656bf8","name":"TIMP-2","description":"A tissue inhibitor of metalloproteinases examined here for a novel role in suppressing tyrosine kinase-type growth factor receptor signaling independently of MMP inhibitory activity.","types":["protein","signaling regulator"],"url":"https://sah.borca.ai/concepts/co_e06238608b5466df275cde4004656bf8"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_5312c92be8ebc79137951e215014f031"}