{"public_id":"cl_5d00ffd9f07ba72ecff374fa7acbdc85","status":"active","superseded_by_public_id":null,"corpus_id":9330608,"text":"The chemosensitizing effects of targeting antiapoptotic proteins are comparable to those of P-glycoprotein inhibition by siRNA or pharmacologic inhibitor.","confidence":0.92,"paper":{"corpus_id":9330608,"title":"siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells","url":"https://sah.borca.ai/papers/9330608"},"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.92,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_164dccbf7455cdd5b67db3e0626bb6c0","name":"P-glycoprotein","description":"A membrane transporter associated with drug efflux and used here as a chemoresistance-related target.","types":["protein"],"url":"https://sah.borca.ai/concepts/co_164dccbf7455cdd5b67db3e0626bb6c0"},{"public_id":"co_17dc2a53d9502a17bb02f6d99a30f2a6","name":"antiapoptotic proteins","description":"Proteins that inhibit apoptosis and can promote cell survival under treatment stress.","types":["protein category"],"url":"https://sah.borca.ai/concepts/co_17dc2a53d9502a17bb02f6d99a30f2a6"},{"public_id":"co_4baa780fa455e2fa346a298f9e23423b","name":"chemoresistant chondrosarcoma cells","description":"Chondrosarcoma cells that show reduced sensitivity to chemotherapy.","types":["cell population"],"url":"https://sah.borca.ai/concepts/co_4baa780fa455e2fa346a298f9e23423b"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_5d00ffd9f07ba72ecff374fa7acbdc85"}