{"public_id":"cl_68720f73d49b0fb86d357cc021e63993","status":"active","superseded_by_public_id":null,"corpus_id":605950,"text":"Sterile rearrangements at the TCR-alpha chain locus are deleted through ordered proximal-to-distal sequential recombination.","confidence":0.93,"paper":{"corpus_id":605950,"title":"T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production","url":"https://sah.borca.ai/papers/605950"},"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.93,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":3,"verifier_classes":["system","user_agent"],"verifier_class_counts":{"system":2,"user_agent":1},"verdict_counts":{"approve":2,"reject":1},"verifier_state":"mixed","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_9babe3c5a69597f28179bdbe8d43115e","name":"sterile rearrangement","description":"An out-of-frame gene recombination that disrupts the reading frame and yields a non-functional receptor product.","types":["molecular outcome"],"url":"https://sah.borca.ai/concepts/co_9babe3c5a69597f28179bdbe8d43115e"},{"public_id":"co_fc201320bd6cfa51df1efbf7bee59b22","name":"TCR-alpha chain gene rearrangement","description":"The somatic recombination event at the TCR alpha locus, occurring after beta chain rearrangement, that generates the alpha chain of the T cell receptor.","types":["biological process"],"url":"https://sah.borca.ai/concepts/co_fc201320bd6cfa51df1efbf7bee59b22"},{"public_id":"co_fde10801c0dca3bc5cc1d87bba9dcda4","name":"sequential recombination","description":"Ordered proximal-to-distal recombination at the TCR-alpha locus that progressively deletes sterile rearrangements through successive recombination events.","types":["mechanism"],"url":"https://sah.borca.ai/concepts/co_fde10801c0dca3bc5cc1d87bba9dcda4"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_68720f73d49b0fb86d357cc021e63993"}