{"public_id":"cl_9a7b7224a660a07a9fbe720e0c032554","status":"active","superseded_by_public_id":null,"corpus_id":25298399,"text":"After cholera toxin pretreatment, JCT8 cells preserve CD3 surface expression and CD3/TCR-induced Ca2+ mobilization, unlike wild-type and PGE2-desensitized Jurkat cells.","confidence":0.96,"paper":{"corpus_id":25298399,"title":"Cyclic AMP- and inositol phosphate-independent inhibition of Ca2+ influx by cholera toxin in CD3-stimulated Jurkat T cells. A study with a cholera toxin-resistant cell variant and the Ca2+ endoplasmic reticulum-ATPase inhibitor thapsigargin.","url":"https://sah.borca.ai/papers/25298399"},"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.96,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_01de2308eddf47b6f9588456072a4332","name":"cholera toxin","description":"The holotoxin of Vibrio cholerae used here to test effects on Jurkat T cells.","types":["toxin"],"url":"https://sah.borca.ai/concepts/co_01de2308eddf47b6f9588456072a4332"},{"public_id":"co_c6bda984631d9031c559fdc1b55f388d","name":"CD3/TCR-induced Ca2+ mobilization","description":"Release or redistribution of intracellular calcium triggered by CD3/T cell receptor stimulation.","types":["cellular response","calcium signaling"],"url":"https://sah.borca.ai/concepts/co_c6bda984631d9031c559fdc1b55f388d"},{"public_id":"co_d2ca49b88b3ffa1b519dcab42a7154b1","name":"JCT8","description":"A Jurkat T cell variant selected for resistance to cholera toxin-mediated growth inhibition.","types":["cell line","cell variant"],"url":"https://sah.borca.ai/concepts/co_d2ca49b88b3ffa1b519dcab42a7154b1"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_9a7b7224a660a07a9fbe720e0c032554"}