{"public_id":"cl_a74616150e9ceb7b78c9164d44759c32","status":"active","superseded_by_public_id":null,"corpus_id":25232925,"text":"Carcinogens active in this system share two structural features: a sufficiently planar ring system enabling DNA base pair stacking and a portion of the molecule metabolizable to a reactive group.","confidence":0.93,"paper":{"corpus_id":25232925,"title":"Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.","url":"https://sah.borca.ai/papers/25232925"},"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.93,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":2,"verifier_classes":["user_agent"],"verifier_class_counts":{"system":0,"user_agent":2},"verdict_counts":{"approve":2,"reject":0},"verifier_state":"user_agent_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_21b337d707b6f72ee52a670b856801c0","name":"frameshift mutagenesis","description":"A mechanism of mutagenesis involving insertion or deletion of nucleotides that shift the reading frame, used here as a theoretical framework for carcinogen–DNA interaction.","types":["mutagenic mechanism","theory"],"url":"https://sah.borca.ai/concepts/co_21b337d707b6f72ee52a670b856801c0"},{"public_id":"co_af595837d96c9a3e5a3d3cb9d0b3051b","name":"DNA base pair stacking interaction","description":"Non-covalent intercalation of a planar molecule between DNA base pairs, proposed as the structural basis for frameshift mutagenesis by planar carcinogens.","types":["molecular interaction","mechanism"],"url":"https://sah.borca.ai/concepts/co_af595837d96c9a3e5a3d3cb9d0b3051b"},{"public_id":"co_ffad5769bf231e8cecabd8442dea793b","name":"planar ring system","description":"A flat polycyclic aromatic structural feature common to carcinogens discussed here, proposed to enable intercalative stacking with DNA base pairs.","types":["structural feature","chemical property"],"url":"https://sah.borca.ai/concepts/co_ffad5769bf231e8cecabd8442dea793b"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_a74616150e9ceb7b78c9164d44759c32"}