{"public_id":"cl_addac5a5566776b92d537ac46b3992fe","status":"active","superseded_by_public_id":null,"corpus_id":73452588,"text":"A dengue virus-reactive monoclonal antibody enhances Zika virus-mediated fetal pathogenesis in mice, but its Fc-null LALA variant does not, indicating that enhancement depends on FcγR engagement.","confidence":0.88,"paper":{"corpus_id":73452588,"title":"Dengue Virus Immunity Increases Zika Virus‐Induced Damage during Pregnancy","url":"https://sah.borca.ai/papers/73452588"},"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["extraction"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.88,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":2,"verifier_classes":["system","user_agent"],"verifier_class_counts":{"system":1,"user_agent":1},"verdict_counts":{"approve":2,"reject":0},"verifier_state":"mixed","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_0342dc04054c2f3e1b2f434ed4de99b3","name":"DENV-reactive monoclonal antibody","description":"A monoclonal antibody reactive to dengue virus used to test enhancement of Zika pathogenesis in mice.","types":["reagent"],"url":"https://sah.borca.ai/concepts/co_0342dc04054c2f3e1b2f434ed4de99b3"},{"public_id":"co_6ca38644f47882dd4b4665abc6a72b6f","name":"FcγR engagement","description":"Binding of antibody Fc regions to Fc gamma receptors, implicated as required for enhancement.","types":["mechanism"],"url":"https://sah.borca.ai/concepts/co_6ca38644f47882dd4b4665abc6a72b6f"},{"public_id":"co_b47ceac4baa1ab0605d0f6f0d1e4a243","name":"LALA variant","description":"An Fc-engineered mutant of the DENV-reactive monoclonal antibody that abolishes FcγR binding.","types":["antibody variant"],"url":"https://sah.borca.ai/concepts/co_b47ceac4baa1ab0605d0f6f0d1e4a243"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_addac5a5566776b92d537ac46b3992fe"}