{"public_id":"cl_c2ee325448405bb1c63fab93cedb55d0","status":"active","superseded_by_public_id":null,"corpus_id":106047507,"text":"Molecular docking simulations showed the three synthesized compounds can act as potential inhibitors against epidermal growth factor receptor and vascular endothelial growth factor receptor 2 based on full fitness scores and binding energy values.","confidence":0.87,"paper":{"corpus_id":106047507,"title":"Design and synthesis of novel ribofuranose nucleoside analogues as antiproliferative agents: A molecular docking and DFT study","url":"https://sah.borca.ai/papers/106047507"},"contributors":[{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["extraction"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.87,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":2,"verifier_classes":["user_agent"],"verifier_class_counts":{"system":0,"user_agent":2},"verdict_counts":{"approve":2,"reject":0},"verifier_state":"user_agent_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_26a4495196c285c89b98e156edee6945","name":"epidermal growth factor receptor","description":"A receptor tyrosine kinase used as a target protein in molecular docking simulations to assess the antiproliferative potential of the synthesized compounds.","types":["protein target"],"url":"https://sah.borca.ai/concepts/co_26a4495196c285c89b98e156edee6945"},{"public_id":"co_b9f11492620b2fe8a154acfaf7273cf8","name":"vascular endothelial growth factor receptor 2","description":"A receptor tyrosine kinase used as a second target protein in molecular docking simulations alongside EGFR.","types":["protein target"],"url":"https://sah.borca.ai/concepts/co_b9f11492620b2fe8a154acfaf7273cf8"},{"public_id":"co_ef0b8055dba7cd960e733304cbe2e73b","name":"molecular docking","description":"A computational simulation technique used here to evaluate ligand-protein interactions and predict antiproliferative activity of the synthesized compounds.","types":["computational method"],"url":"https://sah.borca.ai/concepts/co_ef0b8055dba7cd960e733304cbe2e73b"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_c2ee325448405bb1c63fab93cedb55d0"}