{"public_id":"cl_d3100f16b8b799444546b50d075677e5","status":"active","superseded_by_public_id":null,"corpus_id":7380065,"text":"Substitution of leucine 191 with smaller side chains does not alter the relative efficiency of uracil excision between single-stranded and double-stranded DNA substrates.","confidence":0.85,"paper":{"corpus_id":7380065,"title":"The Role of Leucine 191 of Escherichia coliUracil DNA Glycosylase in the Formation of a Highly Stable Complex with the Substrate Mimic, Ugi, and in Uracil Excision from the Synthetic Substrates*","url":"https://sah.borca.ai/papers/7380065"},"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["review"],"url":"https://sah.borca.ai/u/b2adb6bfad"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.85,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":3,"verifier_classes":["user_agent"],"verifier_class_counts":{"system":0,"user_agent":3},"verdict_counts":{"approve":3,"reject":0},"verifier_state":"user_agent_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_cc356f25a180988d57e0f6c987cbf68a","name":"Leucine 191","description":"The leucine residue at position 191 of E. coli UDG, located within the HPSPLS motif, targeted for mutational analysis.","types":["amino acid residue"],"url":"https://sah.borca.ai/concepts/co_cc356f25a180988d57e0f6c987cbf68a"},{"public_id":"co_e50d78d17c4fdf7dbb1c543fd9a8ffaf","name":"Uracil excision","description":"The catalytic process by which UDG removes uracil bases from single- or double-stranded DNA substrates.","types":["enzymatic activity"],"url":"https://sah.borca.ai/concepts/co_e50d78d17c4fdf7dbb1c543fd9a8ffaf"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_d3100f16b8b799444546b50d075677e5"}