{"public_id":"cl_e15601d6c2abc999c2f435a9f6649b36","status":"active","superseded_by_public_id":null,"corpus_id":38457240,"text":"The proximal tubule distribution of beta-lyase does not support higher S3 concentration as the explanation for the greater sensitivity of the S3 segment to nephrotoxic cysteine conjugates.","confidence":0.94,"paper":{"corpus_id":38457240,"title":"Immunohistochemical localization of glutamine transaminase K, a rat kidney cysteine conjugate beta-lyase, and the relationship to the segment specificity of cysteine conjugate nephrotoxicity.","url":"https://sah.borca.ai/papers/38457240"},"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.94,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_b84af9317ef2fd3ecb27308e1e86e210","name":"cysteine conjugate nephrotoxicity","description":"Kidney toxicity caused by certain cysteine conjugates.","types":["toxicological effect"],"url":"https://sah.borca.ai/concepts/co_b84af9317ef2fd3ecb27308e1e86e210"},{"public_id":"co_d1ca31d4355f8b8b0a3adddb59ed7638","name":"S3 segment","description":"The most sensitive segment of the proximal tubule in this context.","types":["kidney tubule segment"],"url":"https://sah.borca.ai/concepts/co_d1ca31d4355f8b8b0a3adddb59ed7638"},{"public_id":"co_d4a9a3bf89ed0ee6a88c68d939696f29","name":"cysteine conjugate beta-lyase","description":"An enzyme that cleaves cysteine conjugates and contributes to nephrotoxic activation.","types":["enzyme"],"url":"https://sah.borca.ai/concepts/co_d4a9a3bf89ed0ee6a88c68d939696f29"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_e15601d6c2abc999c2f435a9f6649b36"}