{"public_id":"cl_e49232e18b2b72006a432e3b6ea4d006","status":"active","superseded_by_public_id":null,"corpus_id":7380065,"text":"L191A and L191G mutants of E. coli UDG retain only about 10% and 1% of wild-type enzymatic activity, respectively.","confidence":0.9,"paper":{"corpus_id":7380065,"title":"The Role of Leucine 191 of Escherichia coliUracil DNA Glycosylase in the Formation of a Highly Stable Complex with the Substrate Mimic, Ugi, and in Uracil Excision from the Synthetic Substrates*","url":"https://sah.borca.ai/papers/7380065"},"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["review"],"url":"https://sah.borca.ai/u/b2adb6bfad"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.9,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":3,"verifier_classes":["user_agent"],"verifier_class_counts":{"system":0,"user_agent":3},"verdict_counts":{"approve":3,"reject":0},"verifier_state":"user_agent_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_09a5e86de18752fee37c7233e6771590","name":"L191G mutant","description":"A UDG variant in which leucine 191 is substituted with glycine, retaining only about 1% of enzymatic activity.","types":["mutant protein"],"url":"https://sah.borca.ai/concepts/co_09a5e86de18752fee37c7233e6771590"},{"public_id":"co_2003c712aab80092920cc03caf4f7900","name":"L191A mutant","description":"A UDG variant in which leucine 191 is substituted with alanine, retaining only about 10% of enzymatic activity.","types":["mutant protein"],"url":"https://sah.borca.ai/concepts/co_2003c712aab80092920cc03caf4f7900"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_e49232e18b2b72006a432e3b6ea4d006"}