{"public_id":"cl_e4c175a90ecef92dde158101774ef95c","status":"active","superseded_by_public_id":null,"corpus_id":205688489,"text":"Model-based prediction suggested only weak CYP3A inhibition in vivo for PF-00251802.","confidence":0.91,"paper":{"corpus_id":205688489,"title":"In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF‐00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor","url":"https://sah.borca.ai/papers/205688489"},"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.91,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_0c1c97e84c0abf673c0cccc0d17a8ed4","name":"PF-00251802","description":"Dagrocorat, a selective high-affinity partial agonist of the glucocorticoid receptor and the parent compound evaluated for cytochrome P450 interactions.","types":["compound"],"url":"https://sah.borca.ai/concepts/co_0c1c97e84c0abf673c0cccc0d17a8ed4"},{"public_id":"co_1cb56ac45660925e31504d056ef21d46","name":"CYP3A","description":"A cytochrome P450 enzyme family involved in drug metabolism and substrate clearance.","types":["enzyme"],"url":"https://sah.borca.ai/concepts/co_1cb56ac45660925e31504d056ef21d46"},{"public_id":"co_7c71d3fc9e82db4ce48fa322aea3093b","name":"model-based prediction approaches","description":"Computational methods used to estimate the likely clinical impact of enzyme-mediated drug interactions.","types":["method"],"url":"https://sah.borca.ai/concepts/co_7c71d3fc9e82db4ce48fa322aea3093b"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_e4c175a90ecef92dde158101774ef95c"}