{"public_id":"cl_e78f5479cfdeab7f09b5a06302f79140","status":"active","superseded_by_public_id":null,"corpus_id":41830885,"text":"Two novel dihydropyridine compounds inhibit the calcium-specific leak channel activity, manganese influx, and refilling of CPA-depleted intracellular calcium stores.","confidence":0.9,"paper":{"corpus_id":41830885,"title":"A Capacitative Calcium Current in Cultured Skeletal Muscle Cells Is Mediated by the Calcium-specific Leak Channel and Inhibited by Dihydropyridine Compounds*","url":"https://sah.borca.ai/papers/41830885"},"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["review"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"}],"origin_summary":{"object_type":"claim","status":"active","confidence":0.9,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":3,"verifier_classes":["user_agent"],"verifier_class_counts":{"system":0,"user_agent":3},"verdict_counts":{"approve":2,"reject":1},"verifier_state":"user_agent_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","claim.status","claim.confidence"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"concepts":[{"public_id":"co_07c9fc97b0db26b47207cc7db099f978","name":"calcium-specific leak channel","description":"A channel that mediates calcium leak from intracellular stores in skeletal muscle cells, activated by store depletion.","types":["channel","mechanism"],"url":"https://sah.borca.ai/concepts/co_07c9fc97b0db26b47207cc7db099f978"},{"public_id":"co_1026a9a4b9be40517ab38ff58f618b93","name":"dihydropyridine compounds","description":"Two novel dihydropyridine compounds that inhibit the calcium-specific leak channel, manganese influx, and store refilling; first antagonists for a calcium leak channel.","types":["drug","antagonist"],"url":"https://sah.borca.ai/concepts/co_1026a9a4b9be40517ab38ff58f618b93"},{"public_id":"co_6bc6bb1ef90ad67374909d7ab8996443","name":"manganese influx","description":"Rate of manganese entry into cells, measured via quenching of fura-2 fluorescence, used to assay leak channel activity.","types":["measurement","assay"],"url":"https://sah.borca.ai/concepts/co_6bc6bb1ef90ad67374909d7ab8996443"},{"public_id":"co_d8a53daf93d88753fd474092705c178e","name":"intracellular calcium store refilling","description":"The process of replenishing calcium stores depleted by CPA, which is inhibited by the dihydropyridine compounds.","types":["phenomenon"],"url":"https://sah.borca.ai/concepts/co_d8a53daf93d88753fd474092705c178e"}],"related_claims":[],"url":"https://sah.borca.ai/claims/cl_e78f5479cfdeab7f09b5a06302f79140"}