{"public_id":"co_0adfae5a33966e0483ebf1dc640a69d1","status":"active","merged_into_public_id":null,"resolved_public_id":"co_0adfae5a33966e0483ebf1dc640a69d1","name":"AC512","description":"A peptide inverse agonist used to test whether hCTR2-mediated basal signaling is receptor dependent.","aliases":[],"types":["ligand","inverse agonist"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":17639003,"title":"Use of constitutive G protein-coupled receptor activity for drug discovery.","citation_count":103,"url":"https://sah.borca.ai/papers/17639003"}],"claims":[{"public_id":"cl_22bf856741460bdbcd60a587c8ec35aa","text":"Increasing hCTR2 cDNA expression produced constitutively activated receptor levels sufficient to lower light transmittance and enhance the response to human calcitonin, and the effect was reversed by the hCTR2 inverse agonist AC512.","corpus_id":17639003,"url":"https://sah.borca.ai/claims/cl_22bf856741460bdbcd60a587c8ec35aa"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_0adfae5a33966e0483ebf1dc640a69d1","url":"https://sah.borca.ai/concepts/co_0adfae5a33966e0483ebf1dc640a69d1"}