{"public_id":"co_0f8f9c77ba9ce84b26a28aec55866b6b","status":"active","merged_into_public_id":null,"resolved_public_id":"co_0f8f9c77ba9ce84b26a28aec55866b6b","name":"roxithromycin","description":"A macrolide antibacterial agent tested here for amoebicidal activity against N. fowleri, evaluated in vitro and in a mouse infection model.","aliases":[],"types":["drug"],"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":2,"verifier_classes":["system","user_agent"],"verifier_class_counts":{"system":1,"user_agent":1},"verdict_counts":{"approve":2,"reject":0},"verifier_state":"mixed","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":25847740,"title":"Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri.","citation_count":16,"url":"https://sah.borca.ai/papers/25847740"}],"claims":[{"public_id":"cl_78279498d0ef915a747e809078644ff4","text":"In mice with experimental meningoencephalitis due to Naegleria fowleri, survival over 1 month was 25% with roxithromycin treatment and 80% with rokitamycin treatment, with mean times to death of 16.2 and 16.8 days respectively compared with 11.2 days for control mice.","corpus_id":25847740,"url":"https://sah.borca.ai/claims/cl_78279498d0ef915a747e809078644ff4"},{"public_id":"cl_7a3ccdb589e9a4c5cd9b13ba0bde4783","text":"Hygromycin B, rokitamycin, and roxithromycin effectively inhibit the growth of Naegleria fowleri amoebae in vitro.","corpus_id":25847740,"url":"https://sah.borca.ai/claims/cl_7a3ccdb589e9a4c5cd9b13ba0bde4783"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_0f8f9c77ba9ce84b26a28aec55866b6b","url":"https://sah.borca.ai/concepts/co_0f8f9c77ba9ce84b26a28aec55866b6b"}