{"public_id":"co_164dccbf7455cdd5b67db3e0626bb6c0","status":"active","merged_into_public_id":null,"resolved_public_id":"co_164dccbf7455cdd5b67db3e0626bb6c0","name":"P-glycoprotein","description":"A membrane transporter associated with drug efflux and used here as a chemoresistance-related target.","aliases":["P-gp"],"types":["protein"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":9330608,"title":"siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells","citation_count":57,"url":"https://sah.borca.ai/papers/9330608"}],"claims":[{"public_id":"cl_1799d71fce202bee6d530af66bcce495","text":"Antiapoptotic proteins play a significant role in chondrosarcoma chemoresistance independent of P-glycoprotein.","corpus_id":9330608,"url":"https://sah.borca.ai/claims/cl_1799d71fce202bee6d530af66bcce495"},{"public_id":"cl_5d00ffd9f07ba72ecff374fa7acbdc85","text":"The chemosensitizing effects of targeting antiapoptotic proteins are comparable to those of P-glycoprotein inhibition by siRNA or pharmacologic inhibitor.","corpus_id":9330608,"url":"https://sah.borca.ai/claims/cl_5d00ffd9f07ba72ecff374fa7acbdc85"},{"public_id":"cl_fb2a728ae61d3291542a2a589e5b45a0","text":"P-glycoprotein and the antiapoptotic proteins Bcl-2, Bcl-xL, and XIAP are expressed in the two Grade II chondrosarcoma cell lines JJ012 and SW1353.","corpus_id":9330608,"url":"https://sah.borca.ai/claims/cl_fb2a728ae61d3291542a2a589e5b45a0"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_164dccbf7455cdd5b67db3e0626bb6c0","url":"https://sah.borca.ai/concepts/co_164dccbf7455cdd5b67db3e0626bb6c0"}