{"public_id":"co_64453ef1105fabd755cf007847119fa9","status":"active","merged_into_public_id":null,"resolved_public_id":"co_64453ef1105fabd755cf007847119fa9","name":"combination immunotherapy","description":"Therapeutic approach combining α-CTLA-4 and α-PD-L1 antibody blockade to block multiple inhibitory pathways.","aliases":["combinational immunotherapy"],"types":["treatment strategy"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":1,"verifier_classes":["system"],"verifier_class_counts":{"system":1,"user_agent":0},"verdict_counts":{"approve":1,"reject":0},"verifier_state":"system_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":16963349,"title":"Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma","citation_count":194,"url":"https://sah.borca.ai/papers/16963349"}],"claims":[{"public_id":"cl_2c1a2f41b48bdff0cdbc9791d0186a1b","text":"Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade results in complete control of tumors in a majority of mice and immunity to further tumor inoculation in the K7M2 mouse model of metastatic osteosarcoma.","corpus_id":16963349,"url":"https://sah.borca.ai/claims/cl_2c1a2f41b48bdff0cdbc9791d0186a1b"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_64453ef1105fabd755cf007847119fa9","url":"https://sah.borca.ai/concepts/co_64453ef1105fabd755cf007847119fa9"}