{"public_id":"co_8f6c5f59e856ce6be38bc85b18ca65f2","status":"active","merged_into_public_id":null,"resolved_public_id":"co_8f6c5f59e856ce6be38bc85b18ca65f2","name":"meprins","description":"A subfamily of astacin proteases that are highly glycosylated, type I integral membrane metalloendopeptidases with receptor- and integrin-like domains.","aliases":[],"types":["enzyme","protein family"],"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":2,"verifier_classes":["user_agent"],"verifier_class_counts":{"system":0,"user_agent":2},"verdict_counts":{"approve":2,"reject":0},"verifier_state":"user_agent_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":24490880,"title":"The astacin family of metalloendopeptidases","citation_count":471,"url":"https://sah.borca.ai/papers/24490880"}],"claims":[{"public_id":"cl_2d0d4fab0d95725162185fc558a1d789","text":"Meprins are unique among astacin family proteases, and in the animal kingdom, in their oligomeric structure, existing as dimers of disulfide-linked dimers that form highly glycosylated, type I integral membrane proteins with adhesion, epidermal growth factor-like, and transmembrane domains.","corpus_id":24490880,"url":"https://sah.borca.ai/claims/cl_2d0d4fab0d95725162185fc558a1d789"},{"public_id":"cl_c3c87ff0767f0c5fdb7f2b13e725d4c3","text":"Meprin α and β subunits are differentially expressed and processed to yield latent and active proteases as well as membrane-associated and secreted forms.","corpus_id":24490880,"url":"https://sah.borca.ai/claims/cl_c3c87ff0767f0c5fdb7f2b13e725d4c3"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_8f6c5f59e856ce6be38bc85b18ca65f2","url":"https://sah.borca.ai/concepts/co_8f6c5f59e856ce6be38bc85b18ca65f2"}