{"public_id":"co_c02e692e7ce3ed0384061e1570ab7b0b","status":"active","merged_into_public_id":null,"resolved_public_id":"co_c02e692e7ce3ed0384061e1570ab7b0b","name":"NF-κB inhibitors","description":"Agents that inhibit NF-κB signaling and are discussed for their potential interaction with anthracycline-induced apoptosis.","aliases":[],"types":["inhibitor class"],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction","extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":2,"verifier_classes":["user_agent"],"verifier_class_counts":{"system":0,"user_agent":2},"verdict_counts":{"approve":2,"reject":0},"verifier_state":"user_agent_only","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":13587391,"title":"Imatinib Reverses Doxorubicin Resistance by Affecting Activation of STAT3-Dependent NF-κB and HSP27/p38/AKT Pathways and by Inhibiting ABCB1","citation_count":110,"url":"https://sah.borca.ai/papers/13587391"}],"claims":[{"public_id":"cl_49272701c84296feab2c12b1379a0e8b","text":"NF-κB inhibitors may be ineffective or antagonistic for sensitizing tumors with activated c-Abl and Arg to anthracycline-induced apoptosis because imatinib converts NF-κB from a pro-survival factor into a pro-apoptotic factor.","corpus_id":13587391,"url":"https://sah.borca.ai/claims/cl_49272701c84296feab2c12b1379a0e8b"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_c02e692e7ce3ed0384061e1570ab7b0b","url":"https://sah.borca.ai/concepts/co_c02e692e7ce3ed0384061e1570ab7b0b"}