{"public_id":"co_c89033f66affda4ebdb44fd046bbec8f","status":"active","merged_into_public_id":null,"resolved_public_id":"co_c89033f66affda4ebdb44fd046bbec8f","name":"oxitropium bromide","description":"An inhaled anticholinergic bronchodilator used in the dose-response comparisons.","aliases":["oxitropium"],"types":["drug"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":12040695,"title":"Influence of higher than conventional doses of oxitropium bromide on formoterol-induced bronchodilation in COPD.","citation_count":16,"url":"https://sah.borca.ai/papers/12040695"}],"claims":[{"public_id":"cl_8cf341caa9bc54ecd389c1f82c0999da","text":"Formoterol 24 microg alone appears sufficient to achieve bronchodilation comparable to oxitropium bromide 600 microg alone in most patients.","corpus_id":12040695,"url":"https://sah.borca.ai/claims/cl_8cf341caa9bc54ecd389c1f82c0999da"},{"public_id":"cl_bf50b1f271e43e0fb00aa964b92e8f49","text":"Oxitropium bromide produced an evident increase in FEV1, whereas placebo did not show the same dose-response effect.","corpus_id":12040695,"url":"https://sah.borca.ai/claims/cl_bf50b1f271e43e0fb00aa964b92e8f49"},{"public_id":"cl_ce521d7a211ec3892879fd010b4ab4ac","text":"Formoterol pre-treatment increased the FEV1 response to oxitropium bromide by 0.087 l after 12 microg formoterol and by 0.082 l after 24 microg formoterol.","corpus_id":12040695,"url":"https://sah.borca.ai/claims/cl_ce521d7a211ec3892879fd010b4ab4ac"},{"public_id":"cl_ef8ebe1cb0211079f4de0d25333d9fcb","text":"Adding oxitropium bromide 400-600 microg to formoterol can further improve pulmonary function in patients with stable COPD.","corpus_id":12040695,"url":"https://sah.borca.ai/claims/cl_ef8ebe1cb0211079f4de0d25333d9fcb"},{"public_id":"cl_f488b6fe07ac028b16e41c97c7a25871","text":"There is little difference in bronchodilation between combining oxitropium bromide with formoterol 12 microg or with formoterol 24 microg.","corpus_id":12040695,"url":"https://sah.borca.ai/claims/cl_f488b6fe07ac028b16e41c97c7a25871"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_c89033f66affda4ebdb44fd046bbec8f","url":"https://sah.borca.ai/concepts/co_c89033f66affda4ebdb44fd046bbec8f"}