{"public_id":"co_f0333b19f1d537943383fe08d575dd92","status":"active","merged_into_public_id":null,"resolved_public_id":"co_f0333b19f1d537943383fe08d575dd92","name":"p62/Sequestosome 1","description":"An autophagy adaptor protein that accumulates when autophagic degradation is impaired.","aliases":["p62","SQSTM1"],"types":["protein"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":19285940,"title":"Enhanced Epithelial-to-Mesenchymal Transition Associated with Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub","citation_count":47,"url":"https://sah.borca.ai/papers/19285940"}],"claims":[{"public_id":"cl_438058c7a5a4b8177050e3deda64d6bb","text":"Accumulated p62 contributes to the signaling changes linked to lysosome dysfunction, while the Nrf2 and NF-κB pathways do not contribute to the enhanced epithelial-to-mesenchymal transition.","corpus_id":19285940,"url":"https://sah.borca.ai/claims/cl_438058c7a5a4b8177050e3deda64d6bb"},{"public_id":"cl_cc8a0ffa5d149c9286518ac90c129979","text":"Deficient autophagic flux accompanies the enhanced epithelial-to-mesenchymal transition, as shown by increased LC3B-II and p62/Sequestosome 1.","corpus_id":19285940,"url":"https://sah.borca.ai/claims/cl_cc8a0ffa5d149c9286518ac90c129979"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_f0333b19f1d537943383fe08d575dd92","url":"https://sah.borca.ai/concepts/co_f0333b19f1d537943383fe08d575dd92"}