{"public_id":"co_f4d2172f722d7952c01bb0e27fc3f185","status":"active","merged_into_public_id":null,"resolved_public_id":"co_f4d2172f722d7952c01bb0e27fc3f185","name":"candidate gene-by-environment interaction research","description":"Research in psychiatry that tests whether specific genetic variants and environmental exposures interact to influence outcomes.","aliases":["cG×E research","cG×E studies"],"types":["research approach"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":45862988,"title":"A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry.","citation_count":1042,"url":"https://sah.borca.ai/papers/45862988"}],"claims":[{"public_id":"cl_1850b5aa95e628d9d2f73a9da1211fec","text":"The distribution of significant results is consistent with publication bias in novel candidate gene-by-environment interaction studies, which can make these hypotheses appear more robust than they are.","corpus_id":45862988,"url":"https://sah.borca.ai/claims/cl_1850b5aa95e628d9d2f73a9da1211fec"},{"public_id":"cl_1a9652152cd9d433f14a4d01c6a77998","text":"Among the 103 published psychiatric candidate gene-by-environment interaction studies from 2000-2009, 96% of novel studies were significant versus 27% of replication attempts.","corpus_id":45862988,"url":"https://sah.borca.ai/claims/cl_1a9652152cd9d433f14a4d01c6a77998"},{"public_id":"cl_c9a2221efe3ad010a441c5645807f90a","text":"Observed sample sizes indicate that candidate gene-by-environment interaction studies are underpowered.","corpus_id":45862988,"url":"https://sah.borca.ai/claims/cl_c9a2221efe3ad010a441c5645807f90a"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_f4d2172f722d7952c01bb0e27fc3f185","url":"https://sah.borca.ai/concepts/co_f4d2172f722d7952c01bb0e27fc3f185"}