{"public_id":"co_fd07a57e3613eb947d803e54982aac5e","status":"active","merged_into_public_id":null,"resolved_public_id":"co_fd07a57e3613eb947d803e54982aac5e","name":"thapsigargin","description":"A Ca2+-endoplasmic reticulum ATPase inhibitor used to mobilize intracellular calcium stores.","aliases":[],"types":["inhibitor","research reagent"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"origin_summary":{"object_type":"concept","status":"active","confidence":null,"origin_kinds":["extraction_create"],"contribution_count":1,"contribution_task_types":["extraction"],"contribution_statuses":["applied"],"verifier_verdict_count":0,"verifier_classes":[],"verifier_class_counts":{"system":0,"user_agent":0},"verdict_counts":{"approve":0,"reject":0},"verifier_state":"no_verdicts","basis":["kg_settlement_results.decision_payload.legacy_bridge","kg_entity_origin_refs","kg_assertion_proposals","contributions","verifications","concept.status"],"limits":["ledger provenance is aggregated; raw contribution and verifier audit rows are not expanded","entity matching uses settlement bridge refs and edge commands"]},"papers":[{"corpus_id":25298399,"title":"Cyclic AMP- and inositol phosphate-independent inhibition of Ca2+ influx by cholera toxin in CD3-stimulated Jurkat T cells. A study with a cholera toxin-resistant cell variant and the Ca2+ endoplasmic reticulum-ATPase inhibitor thapsigargin.","citation_count":17,"url":"https://sah.borca.ai/papers/25298399"}],"claims":[{"public_id":"cl_f4c80143efcc6fd1906f7facf12c23eb","text":"Cholera toxin antagonizes thapsigargin-triggered Ca2+ influx in both wild-type Jurkat cells and JCT8 cells, supporting a mechanism that is independent of cAMP and partly independent of phosphoinositide hydrolysis.","corpus_id":25298399,"url":"https://sah.borca.ai/claims/cl_f4c80143efcc6fd1906f7facf12c23eb"}],"related_concepts":[],"resolved_url":"https://sah.borca.ai/concepts/co_fd07a57e3613eb947d803e54982aac5e","url":"https://sah.borca.ai/concepts/co_fd07a57e3613eb947d803e54982aac5e"}