K. Chan

PROFILE

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Aliases
Keith Chan, Keith S Chan, Keith S. Chan, Keith Syson Chan
Publication record
61 papers · 5,888 citations · H-index 27

PAPERS

Dual stromal targeting sensitizes pancreatic adenocarcinoma for anti-PD-1 therapy.
202241 citationsauthor #15
circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment
202215 citationsauthor #15
MP59-09 CHARACTERIZING MOLECULAR SUBTYPES OF HIGH-RISK NON-MUSCLE-INVASIVE BLADDER CANCER IN AFRICAN AMERICAN PATIENTS
20220 citationsauthor #12
Understanding Drug Sensitivity and Tackling Resistance in Cancer
202245 citationsauthor #10
Characterizing molecular subtypes of high-risk nonmuscle-invasive bladder cancer in African American patients.
20220 citationsauthor #11
Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors
202233 citationsauthor #15
The dynamic roles of the bladder tumour microenvironment
202264 citationsauthor #6
Discoidin domain receptor-driven gene signatures as markers of patient response to anti-PD-L1 immune checkpoint therapy.
20228 citationsauthor #11
Cabozantinib plus Nivolumab Phase I Expansion Study in Patients with Metastatic Urothelial Carcinoma Refractory to Immune Checkpoint Inhibitor Therapy
202219 citationsauthor #17
Characterizing molecular subtypes of high-risk non-muscle-invasive bladder cancer in African American patients.
20229 citationsauthor #12
Loss of CDCP1 triggers FAK activation in detached prostate cancer cells.
20212 citationsauthor #13
Inhibitory DAMPs in immunogenic cell death and its clinical implications
202116 citationsauthor #3
miR-1227 Targets SEC23A to Regulate the Shedding of Large Extracellular Vesicles
20217 citationsauthor #14
An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer
2021129 citationsauthor #8
RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
202127 citationsauthor #5
Abstract IA09: Collagen microenvironment in the modulation of local invasion and distal metastasis
20200 citationsauthor #2
Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy
202032 citationsauthor #5
Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy
20205 citationsauthor #5
Reply To Kenneth B. Yatai, Mark J. Dunning, Dennis Wang. Consensus Genomic Subtypes of Muscle-invasive Bladder Cancer: A Step in the Right Direction but Still a Long Way To Go. Eur Urol. In press.
20201 citationsauthor #22
Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model
202010 citationsauthor #13
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer
20191,049 citationsauthor #25
Prognostic Significance of Lymphocyte Infiltration and a Stromal Immunostaining of a Bladder Cancer Associated Diagnostic Panel in Urothelial Carcinoma
201910 citationsauthor #7
Reply To Kenneth B. Yatai, Mark J. Dunning, Dennis Wang. Consensus Genomic Subtypes of Muscle-invasive Bladder Cancer: A Step in the Right Direction but Still a Long Way To Go. Eur Urol 2020;77:434 – 5
20190 citationsauthor #19
Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
201939 citationsauthor #17
Abstract 1647: Integrative subtype analysis of muscle-invasive bladder cancer reveals subtypes that have different overall survival and respond differently to neoadjuvant chemotherapy
20190 citationsauthor #3
Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas
2018130 citationsauthor #9
A fully Bayesian latent variable model for integrative clustering analysis of multi-type omics data.
2018206 citationsauthor #5
Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy.
201721 citationsauthor #7
Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting
2016200 citationsauthor #4
Positive association of collagen type I with non-muscle invasive bladder cancer progression
201663 citationsauthor #15
Molecular Pathways: Targeting Cancer Stem Cells Awakened by Chemotherapy to Abrogate Tumor Repopulation
201538 citationsauthor #1
Abstract 5470: Blocking wound-induced tumor repopulation between chemotherapy cycles as a novel approach to abrogate chemoresistance
20150 citationsauthor #11
Cancer stem cells and intrinsic subtypes in bladder cancer
20151 citationsauthor #1
Abstract 1928: Reporter construct for functional and real-time evaluation of cytokeratin 14+ bladder cancer stem cells
20140 citationsauthor #8
RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation
2014149 citationsauthor #4
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance
2014535 citationsauthor #11
Abstract 4801: Stromal-mediated collagen I signal in promoting bladder cancer progression
20140 citationsauthor #7
The preclinical anti-angiogenic and pro-apoptotic activity of lenalidomide in urothelial carcinoma (UC).
20130 citationsauthor #2
Three differentiation states risk-stratify bladder cancer into distinct subtypes
2012253 citationsauthor #20
Cancer Stem Cells: Paradigm Shifting or Perishing Concept?
20120 citationsauthor #2
Normal and neoplastic urothelial stem cells: getting to the root of the problem
2012178 citationsauthor #3
The preclinical activity of lenalidomide in urothelial carcinoma (UC).
20120 citationsauthor #2
Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer.
2012129 citationsauthor #5
Priority Report Stat 3 Activation in Urothelial Stem Cells Leads to Direct Progression to Invasive Bladder Cancer
20120 citationsauthor #5
Cancer Stem Cells. Edited by William L. Farrar. Cambridge and New York: Cambridge University Press. $95.00. x + 171 p. + 8 pl.; ill.; index. ISBN: 978-0-521-89628-3. 2010.
20110 citationsauthor #1
Cancer stem cells in bladder cancer: a revisited and evolving concept
201078 citationsauthor #1
965 CHARACTERIZATION AND PRECLINICAL TARGETING OF HUMAN BLADDER CANCER STEM CELLS
20100 citationsauthor #1
Imaging of STAT3 Signaling Pathway During Mouse Embryonic Stem Cell Differentiation
200937 citationsauthor #2
Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
2009649 citationsauthor #1
Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases.
2008192 citationsauthor #2
Molecular profiling reveals heterogeneity of active self-renewal pathways in bladder cancer stem cells
20082 citationsauthor #1
Abstract 4998: Molecular profiling reveals heterogeneity of active self-renewal pathways in bladder cancer stem cells
20080 citationsauthor #1
Analytical protein measurements from 400 tumor-derived stem cells
20070 citationsauthor #2
767: Identification and Characterization of Cancer Stem Cells in Bladder Cancer
20070 citationsauthor #1
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
2005750 citationsauthor #2
Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation.
2005106 citationsauthor #2
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.
2004358 citationsauthor #1
Epidermal Growth Factor Receptor-Mediated Activation of Stat3 during Multistage Skin Carcinogenesis
2004164 citationsauthor #1
Significance of signal transducer and activator of transcription 3 during multistage mouse skin carcinogenesis
20040 citationsauthor #1
Advances in Brief Constitutive Expression of ErbB2 in Gallbladder Epithelium Results in Development of Adenocarcinoma 1
20012 citationsauthor #3
Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development
200087 citationsauthor #6

TIMELINE

2000 87 citations

2001 2 citations

2004 522 citations

2005 856 citations

2007 0 citations

2008 194 citations

2009 686 citations

2010 78 citations

2011 0 citations

2012 560 citations

2013 0 citations

2014 684 citations

2015 39 citations

2016 263 citations

2017 21 citations

2018 336 citations

2019 1,098 citations

2020 48 citations

2021 181 citations

2022 234 citations

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