J. Silber

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Aliases
John Silber, John R Silber, J. Silber, John Randall Silber, J. R. Silber, John R. Silber, J R Silber, J Silber
Publication record
88 papers · 4,017 citations · H-index 36

PAPERS

siRNA Nanoparticle Suppresses Drug‐Resistant Gene and Prolongs Survival in an Orthotopic Glioblastoma Xenograft Mouse Model
202041 citationsauthor #6
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
202046 citationsauthor #13
TMOD-30. CHARACTERIZATION OF AN ALTERNATIVELY SPLICED NTRK2 VARIANT IN GLIOMAS
20190 citationsauthor #11
CSIG-17. CHARACTERIZATION OF AN ALTERNATIVELY SPLICED NTRK2 VARIANT IN GLIOMA: EMPLOYING NOVEL REAGENTS TO UNCOVER NOVEL FUNCTIONS
20180 citationsauthor #10
Effects of tumor grade and dexamethasone on myeloid cells in patients with glioma
201815 citationsauthor #14
pH-Sensitive O6-Benzylguanosine Polymer Modified Magnetic Nanoparticles for Treatment of Glioblastomas.
201717 citationsauthor #6
Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma.
201739 citationsauthor #5
Towards use of MRI-guided ultrasound for treating cerebral vasospasm
20168 citationsauthor #2
Culture on 3D Chitosan‐Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells
201668 citationsauthor #4
EXTH-05. NANOPARTICLE-MEDIATED INHIBITION OF DNA REPAIR INCREASES SURVIVAL IN A GENETIC AFTER RADIOTHERAPY
20160 citationsauthor #5
TR-04NANOPARTICLE siRNA DELIVERY VEHICLES INHIBIT DNA REPAIR AND SENSITIZE PEDIATRIC BRAIN TUMOR CELLS TO RADIATION THERAPY
20150 citationsauthor #5
Periostin is a novel therapeutic target that predicts and regulates glioma malignancy.
201580 citationsauthor #15
Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ‐irradiation
201565 citationsauthor #7
Nanoparticle‐Mediated Target Delivery of TRAIL as Gene Therapy for Glioblastoma
201576 citationsauthor #4
Comparative Proteomic Profiling Using Two-Dimensional Gel Electrophoresis and Identification via LC-MS/MS Reveals Protein Biomarkers That Distinguish Aggressive from Non-Aggressive Phenotypes of Who Grade I Meningioma
20140 citationsauthor #6
Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes
20145 citationsauthor #7
Proliferation and enrichment of CD133(+) glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds.
2014115 citationsauthor #6
Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes
201477 citationsauthor #7
O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma
201427 citationsauthor #9
NT-16NANOPARTICLE-MEDIATED DELIVERY OF ANTI-Ape1 siRNA SENSITIZES PEDIATRIC BRAIN TUMOR CELLS TO RADIATION THERAPY BY INHIBITING DNA REPAIR.
20140 citationsauthor #6
Redox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O6-Benzylguanine to Brain Tumors
2014165 citationsauthor #9
OMICS AND PROGNSTIC MARKERS
20131 citationsauthor #412
Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain
201363 citationsauthor #5
EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY
20132 citationsauthor #312
Synthesis and characterization of DNA minor groove binding alkylating agents.
201316 citationsauthor #11
LAB-TUMOR MODELS (IN VIVO/IN VITRO)
20120 citationsauthor #88
Increased age of transformed mouse neural progenitor/stem cells recapitulates age‐dependent clinical features of human glioma malignancy
201215 citationsauthor #9
LAB-CELL BIOLOGY AND SIGNALING
20121 citationsauthor #281
Repair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomide
201234 citationsauthor #5
O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems.
201294 citationsauthor #1
Low Leukocyte MGMT Accompanies Temozolomide-Induced Myelotoxicity in Brain Tumor Patients
20121 citationsauthor #4
Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro.
2011275 citationsauthor #6
Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma
201132 citationsauthor #8
Medical and Neuro-Oncology
20102 citationsauthor #288
Medical and Neuro-Oncology
20102 citationsauthor #42
TWIST1 promotes invasion through mesenchymal change in human glioblastoma
2010263 citationsauthor #12
Minimally Cytotoxic Doses of Temozolomide Produce Radiosensitization in Human Glioblastoma Cells Regardless of MGMT Expression
201040 citationsauthor #4
O6-methylguanine-DNA methyltransferase deficiency in developing brain: implications for brain tumorigenesis.
200723 citationsauthor #5
Human Glioma Cell Sensitivity to the Sequence-Specific Alkylating Agent Methyl-Lexitropsin
200734 citationsauthor #8
Complications of a temozolomide overdose: a case report
200612 citationsauthor #5
06-Methylguanine-DNA Methyltransferase Activity in Adult ( Â ¿ liornas : Relation to Patient and Tumor Characteristics 1
20060 citationsauthor #1
06-Methylguanine-DNA Methyltransferase Activity in Adult ( Â ¿ liornas : Relation to Patient and Tumor Characteristics 1
20060 citationsauthor #1
Comparison of O 6-Methylguanine-DNA Methyltransferase Activity in Brain T \ imors and Adjacent Normal Brain 1
20060 citationsauthor #1
Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy
20050 citationsauthor #59
185 MISMATCH REPAIR DEFICIENCY ELIMINATES DEPENDENCY ON WRN FOR GLIOMA CELL LINE RESISTANCE TO O6-METHYLGUANINE
20050 citationsauthor #2
TWIST is expressed in human gliomas and promotes invasion.
2005194 citationsauthor #3
O6-Methylguanine-DNA Methyltransferase, O6-Benzylguanine, and Resistance to Clinical Alkylators in Pediatric Primary Brain Tumor Cell Lines
200598 citationsauthor #2
Apurinic/Apyrimidinic Endonuclease Activity Is Associated with Response to Radiation and Chemotherapy in Medulloblastoma and Primitive Neuroectodermal Tumors
2005103 citationsauthor #9
O 6-Methylguanine-DNAMethyltransferase , O 6-Benzylguanine , and Resistance to Clinical Alkylators in Pediatric Primary BrainTumor Cell Lines
200512 citationsauthor #2
Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy
20050 citationsauthor #205
Apurinic Endonuclease Activity in Adult Gliomas and Time to Tumor Progression after Alkylating Agent-Based Chemotherapy and after Radiotherapy
200454 citationsauthor #10
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.
200444 citationsauthor #9
IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein
200231 citationsauthor #3
A novel flow cytometric technique for drug cytotoxicity gives results comparable to colony-forming assays.
200217 citationsauthor #2
Werner syndrome diploid fibroblasts are sensitive to 4‐nitroquinoline‐N‐oxide and 8‐methoxypsoralen: implications for the disease phenotype
200294 citationsauthor #4
IL-4 receptors on human tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein.
20021 citationsauthor #3
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.
2002156 citationsauthor #1
O6-Methylguanine-DNA methyltransferase in pediatric primary brain tumors: relation to patient and tumor characteristics.
200149 citationsauthor #6
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.
2001139 citationsauthor #5
Characterization of paclitaxel (Taxol) sensitivity in human glioma- and medulloblastoma-derived cell lines.
199931 citationsauthor #4
Lipid Association Increases the Potency Against Primary Medulloblastoma Cells and Systemic Exposure of l-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosourea (CCNU) in Rats
19994 citationsauthor #4
O6-methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: frequency and time to tumor progression after alkylating agent-based chemotherapy.
1999145 citationsauthor #1
Microsatellite instability is infrequent in sporadic adult gliomas.
199816 citationsauthor #4
O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics.
1998155 citationsauthor #1
p53 Expression in four human medulloblastoma-derived cell lines
19963 citationsauthor #3
Comparative analyses of relative ERCC3 and ERCC6 mRNA levels in gliomas and adjacent non‐neoplastic brain
199617 citationsauthor #8
Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors.
199684 citationsauthor #1
Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin.
1996109 citationsauthor #5
Establishment and characterization of four human medulloblastoma-derived cell lines.
199598 citationsauthor #6
Malignant and nonmalignant brain tissues differ in their messenger RNA expression patterns for ERCC1 and ERCC2.
199555 citationsauthor #5
Contribution of O6‐methylguanine‐DNA methyltransferase to monofunctional alkylating‐agent resistance in human brain tumor—derived cell lines
199546 citationsauthor #4
Contribution of O6‐methylguanine‐DNA methyltransferase to resistance to 1,3‐(2‐chloroethyl)‐1‐nitrosourea in human brain tumor‐derived cell lines
199552 citationsauthor #3
Urokinase plasminogen activator is elevated in human astrocytic gliomas relative to normal adjacent brain.
199319 citationsauthor #4
Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain.
1993109 citationsauthor #1
The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence.
19927 citationsauthor #1
Expression of glial fibrillary acidic protein in human medulloblastoma cells treated with recombinant glia maturation factor-beta.
199213 citationsauthor #6
O6-alkylguanine DNA-alkyltransferase is not a major determinant of sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea in four medulloblastoma cell lines.
199226 citationsauthor #1
Relationship of Cholesterol to DNA Synthesis in Normal and Cancerous Cells
19873 citationsauthor #3
Fidelity of DNA polymerases isolated from regenerating liver chromatin of aging Mus musculus.
198529 citationsauthor #1
FIDELITY OF DNA SYNTHESIS DURING AGING
19843 citationsauthor #3
Excision repair participates in the Weigle reactivation of ultraviolet light-irradiated phi X174 double-stranded DNA.
19845 citationsauthor #1
Delayed and reduced cell replication and diminishing levels of DNA polymerase‐α in regenerating liver of aging mice
198486 citationsauthor #2
Infidelity of DNA synthesis as a cause of mutagenesis.
19832 citationsauthor #4
Detection of enzymatic activities in sodium dodecyl sulfate-polyacrylamide gels: DNA polymerases as model enzymes.
198365 citationsauthor #2
The mutagenic effect of deoxynucleotide substrate imbalances during DNA synthesis with mammalian DNA polymerases.
198245 citationsauthor #2
S1 nuclease does not cleave DNA at single-base mis-matches.
198135 citationsauthor #1
Ultraviolet light-induced recovery in Escherichia coli of gamma-irradiated bacteriophage DNA.
197911 citationsauthor #1
Ultraviolet light induced recovery in Escherichia Coli of radiation damaged bacteriophage deoxyribonucleic acid / by John Randall Silber.
19770 citationsauthor #1

TIMELINE

1977 0 citations

1979 11 citations

1981 35 citations

1982 45 citations

1983 67 citations

1984 94 citations

1985 29 citations

1987 3 citations

1992 46 citations

1993 128 citations

1995 251 citations

1996 213 citations

1998 171 citations

1999 180 citations

2001 188 citations

2002 299 citations

2004 98 citations

2005 407 citations

2006 12 citations

2007 57 citations

2010 305 citations

2011 307 citations

2012 145 citations

2013 82 citations

2014 389 citations

2015 221 citations

2016 76 citations

2017 56 citations

2018 15 citations

2019 0 citations

2020 87 citations

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