S. Joshi

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Aliases
Shailen K Joshi, S. K. Joshi, Shailen K. Joshi, S K Joshi, Shailen Joshi
Publication record
37 papers · 2,229 citations · H-index 25

PAPERS

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.
201631 citationsauthor #27
Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639.
201519 citationsauthor #3
Corrigendum to “A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats” [Biochem. Pharmacol. 89 (4) (2014) 536–544]
20150 citationsauthor #8
A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.
201470 citationsauthor #8
Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.
201438 citationsauthor #25
Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.
201412 citationsauthor #24
Pharmacological modulation of brain activity in a preclinical model of osteoarthritis
201326 citationsauthor #11
Pharmacology of Modality-Specific TRPV1 Antagonists That Do Not Alter Body Temperature
20120 citationsauthor #4
PARP inhibitors attenuate chemotherapy‐induced painful neuropathy
201229 citationsauthor #2
Estimating efficacy and drug ED50's using von Frey thresholds: impact of weber's law and log transformation.
2012121 citationsauthor #3
Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature
201277 citationsauthor #4
Development and validation of mechanical allodynia as a pain readout in a preclinical model of osteoarthritis
20128 citationsauthor #5
Blockade of both IL-1A and IL-1B by a combination of monoclonal antibodies prevents the development and reverses established pain in a preclinical model of osteoarthritis
201210 citationsauthor #5
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.
201142 citationsauthor #9
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
2011269 citationsauthor #2
TRPV1-related modulation of spinal neuronal activity and behavior in a rat model of osteoarthritic pain.
201150 citationsauthor #3
In Vitro and in Vivo Assays for the Discovery of Analgesic Drugs Targeting TRP Channels
20113 citationsauthor #4
A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
201055 citationsauthor #9
A‐995662 [(R)‐8‐(4‐methyl‐5‐(4‐(trifluoromethyl)phenyl)oxazol‐2‐ylamino)‐1,2,3,4‐tetrahydronaphthalen‐2‐ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
201068 citationsauthor #3
Role of TRPV1 Receptors in Osteoarthritic Pain
20101 citationsauthor #1
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
201033 citationsauthor #15
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
201027 citationsauthor #20
Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists.
201032 citationsauthor #10
Repeated dosing of ABT‐102, a potent and selective TRPV1 antagonist, enhances TRPV1‐mediated analgesic activity in rodents, but attenuates antagonist‐induced hyperthermia
2009134 citationsauthor #7
Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.
200856 citationsauthor #6
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.
200825 citationsauthor #20
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
200881 citationsauthor #19
Morphine and ABT-594 (a nicotinic acetylcholine agonist) exert centrally mediated antinociception in the rat cyclophosphamide cystitis model of visceral pain.
200836 citationsauthor #1
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
2007493 citationsauthor #5
Involvement of the TTX‐resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post‐operative, pain states
2006173 citationsauthor #1
Animal models of pain for drug discovery
200622 citationsauthor #1
Nonopioid Actions of U50,488 Enantiomers Contribute to Their Peripheral Cutaneous Antinociceptive Effects
200314 citationsauthor #1
Erratum: κ-opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action (Journal of Neuroscience (August 1, 2000) (5874-5879))
20021 citationsauthor #1
Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effects.
200269 citationsauthor #2
5-HT, receptor agonists stimulate small intestinal transit but do not have direct visceral antinociceptive effects in the rat
200112 citationsauthor #6
kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action.
200056 citationsauthor #1
Peripheral Opioid Modulation of Visceral Pain a
200039 citationsauthor #3

TIMELINE

2000 95 citations

2001 12 citations

2002 70 citations

2003 14 citations

2006 195 citations

2007 493 citations

2008 198 citations

2009 134 citations

2010 216 citations

2011 364 citations

2012 245 citations

2013 26 citations

2014 120 citations

2015 19 citations

2016 31 citations

S. Joshi

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