J. Withka

PROFILE

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Aliases
Jane Withka, J Withka, Jane M. Withka, Jane m. Withka, J M Withka, Jane M Withka
Publication record
55 papers · 3,460 citations · H-index 31

PAPERS

Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
20214 citationsauthor #16
NMR spectroscopy: the swiss army knife of drug discovery
202011 citationsauthor #4
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
202031 citationsauthor #41
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
201820 citationsauthor #27
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
201812 citationsauthor #37
Biophysical Interactions of Direct AMPK Activators.
20182 citationsauthor #5
An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
201836 citationsauthor #13
Driving Drug Discovery with Biophysical Information
20172 citationsauthor #21
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
201742 citationsauthor #31
Small molecule and peptidic ligands as PCSK9-LDLR inhibitors
20170 citationsauthor #28
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
201644 citationsauthor #22
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
2016105 citationsauthor #8
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
201643 citationsauthor #4
Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators
201564 citationsauthor #8
Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.
201545 citationsauthor #17
NMR solution structure for di-sulfide 11mer peptide
20150 citationsauthor #17
NMR structure of a short hydrophobic 11mer peptide in 25 mM SDS solution
20150 citationsauthor #17
NMR structure of a short hydrophobic 11mer peptide in DMSO-d6/H2O (1:3) solution
20150 citationsauthor #17
NMR solution structure for lactam (5,9) 11mer
20150 citationsauthor #17
Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
201458 citationsauthor #3
Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia risk
20148 citationsauthor #21
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
2014178 citationsauthor #6
Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design.
201259 citationsauthor #18
Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
201263 citationsauthor #13
Crystal Structure of BACE with Compound 12a
20120 citationsauthor #13
Glycomimetic ligands for the human asialoglycoprotein receptor.
201292 citationsauthor #6
Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics
201157 citationsauthor #2
P3‐282: β‐secretase inhibitors for treatment of Alzheimer's disease
20101 citationsauthor #23
1 SRT 1720 , SRT 2183 , SRT 1460 , AND RESVERATROL ARE NOT DIRECT ACTIVATORS OF SIRT 1
201080 citationsauthor #14
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦
2010892 citationsauthor #16
Methodological considerations on molecular dynamics simulations of DNA oligonucleotides
20080 citationsauthor #4
Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists.
200811 citationsauthor #11
Glucagon-like peptide-1 and analogs: A structure/function analysis
20020 citationsauthor #8
Cyclization of N-terminal S-carbamoylmethylcysteine causing loss of 17 Da from peptides and extra peaks in peptide maps.
200254 citationsauthor #5
Synthesis of macrocyclic, potential protease inhibitors using a generic scaffold.
200226 citationsauthor #7
Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines.
200133 citationsauthor #7
Compensating for Variations in 1H−13C Scalar Coupling Constants in Isotope-Filtered NMR Experiments
199949 citationsauthor #3
Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins.
1995252 citationsauthor #2
A thermodynamic scale for the beta-sheet forming tendencies of the amino acids.
1994380 citationsauthor #2
The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain.
199380 citationsauthor #2
Molecular Dynamics Simulations on the Hydration, Structure and Motions of DNA Oligomers
199342 citationsauthor #4
1H resonance assignments and secondary structure of the 13.6 kDa glycosylated adhesion domain of human CD2.
199335 citationsauthor #2
Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2.
199358 citationsauthor #1
A Thermodynamic Scale for the , & Sheet Forming Tendencies of the Amino Acids
199382 citationsauthor #2
Toward a dynamical structure of DNA: comparison of theoretical and experimental NOE intensities.
199249 citationsauthor #1
Effects of the presence of an aldehydic abasic site on the thermal stability and rates of helix opening and closing of duplex DNA.
199224 citationsauthor #2
Problems with, and alternatives to, the NMR R factor
199223 citationsauthor #1
A Critique of the Interpretation of Nuclear Overhauser Effects of Duplex DNA
19910 citationsauthor #1
Time dependence of nuclear Overhauser effects of duplex DNA from molecular dynamics trajectories
199133 citationsauthor #1
Stereochemical studies of the beta-elimination reactions at aldehydic abasic sites in DNA: endonuclease III from Escherichia coli, sodium hydroxide, and Lys-Trp-Lys.
1991145 citationsauthor #6
Characterization of conformational features of DNA heteroduplexes containing aldehydic abasic sites.
199142 citationsauthor #1
NOES in duplex DNA depend on orientations of internuclear vectors to the symmetry axis
199017 citationsauthor #1
Molecular dynamics of an in vacuo model of duplex d(CGCGAATTCGCG) in the B-form based on the amber 3.0 force field.
199031 citationsauthor #2
Use of high-performance size-exclusion, ion-exchange, and hydrophobic interaction chromatography for the measurement of protein conformational change and stability.
198734 citationsauthor #1
Coexistence of conformations in a DNA heteroduplex revealed by site specific labeling with 13C-labeled nucleotides
198713 citationsauthor #4

TIMELINE

1987 47 citations

1990 48 citations

1991 220 citations

1992 96 citations

1993 297 citations

1994 380 citations

1995 252 citations

1999 49 citations

2001 33 citations

2002 80 citations

2008 11 citations

2010 973 citations

2011 57 citations

2012 214 citations

2014 244 citations

2015 109 citations

2016 192 citations

2017 44 citations

2018 70 citations

2020 42 citations

2021 4 citations

J. Withka

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