M. Howell

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Aliases
M Howell, M. Howell, Mike Howell, Michael Howell
Publication record
94 papers · 7,356 citations · H-index 43

PAPERS

A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses
20228 citationsauthor #6
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease
202146 citationsauthor #14
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease
202129 citationsauthor #12
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase
202127 citationsauthor #10
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay
202114 citationsauthor #17
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase
202135 citationsauthor #19
Correction: WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer
20210 citationsauthor #11
Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains
202142 citationsauthor #26
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease
202131 citationsauthor #18
Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase
20215 citationsauthor #19
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution.
202196 citationsauthor #29
Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype
20213 citationsauthor #17
AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC
2021115 citationsauthor #18
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease
202129 citationsauthor #18
Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination
2021485 citationsauthor #19
Functional profiling of long intergenic non-coding RNAs in fission yeast
202115 citationsauthor #13
Adaptive immunity to SARS-CoV-2 in cancer patients: The CAPTURE study
20207 citationsauthor #21
GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells
202057 citationsauthor #9
Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN‐null triple negative breast cancer
202022 citationsauthor #6
SARS-CoV-2 detection using BGI RT-PCR kit v1
20200 citationsauthor #12
Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway
202044 citationsauthor #9
Scalable and Resilient SARS-CoV2 testing in an Academic Centre
202012 citationsauthor #29
WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer
202021 citationsauthor #11
Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis
202036 citationsauthor #16
Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
201932 citationsauthor #9
MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma.
201931 citationsauthor #14
Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases
201943 citationsauthor #7
Inherited duplications of PPP2R3B promote naevi and melanoma via a novel C21orf91-driven proliferative phenotype
20190 citationsauthor #17
Identification and Validation of Novel Autophagy Regulators Using an Endogenous Readout siGENOME Screen.
20191 citationsauthor #8
A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice
201979 citationsauthor #10
Defining host–pathogen interactions employing an artificial intelligence workflow
201972 citationsauthor #6
Patient-specific detection of cancer genes reveals recurrently perturbed processes in esophageal adenocarcinoma
20186 citationsauthor #9
An Artificial Intelligence Workflow for Defining Host-Pathogen Interactions
20186 citationsauthor #6
A genome-wide RNAi screen identifies the SMC 5 / 6 complex as a non-redundant regulator of a Topo 2 a-dependent G 2 arrest
20183 citationsauthor #3
The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery.
201830 citationsauthor #8
A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest
201823 citationsauthor #3
20 Identification of combinatorial therapies with inhibitors of the PI3K pathway in PTEN-null tumours
20180 citationsauthor #2
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
2018304 citationsauthor #8
Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export
2018124 citationsauthor #4
Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication
201729 citationsauthor #3
UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene
2017166 citationsauthor #11
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
201798 citationsauthor #8
APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.
2017104 citationsauthor #13
Actin and Src-family kinases regulate nuclear YAP1 and its export
20172 citationsauthor #4
Alternative non-coding and coding ASCC3 transcript isoforms with opposite roles in DNA damage response
20170 citationsauthor #11
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
2016216 citationsauthor #11
Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion
201652 citationsauthor #11
High-throughput screening approaches to identify regulators of mammalian autophagy.
201515 citationsauthor #4
Genome-Wide siRNA Screen for Anti-Cancer Drug Resistance in Adherent Cell Lines
20150 citationsauthor #3
The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17
201549 citationsauthor #12
Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival
201584 citationsauthor #14
Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
2015729 citationsauthor #17
Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion
201467 citationsauthor #4
Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability
201447 citationsauthor #9
Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.
201475 citationsauthor #5
Corrigendum: Replication stress links structural and numerical cancer chromosomal instability
20132 citationsauthor #15
The centriolar satellite protein Cep131 is important for genome stability
201320 citationsauthor #7
Affordable Luciferase Reporter Assay for Cell-Based High-Throughput Screening
201353 citationsauthor #4
Replication stress links structural and numerical cancer chromosomal instability
2013835 citationsauthor #15
XSmad 2 directly activates the activin-inducible , dorsal mesoderm gene XFKH 1 in Xenopus embryos
20131 citationsauthor #1
HTS-DB: an online resource to publish and query data from functional genomics high-throughput siRNA screening projects
20132 citationsauthor #5
Anomalous inhibition of c‐Met by the kinesin inhibitor aurintricarboxylic acid
20126 citationsauthor #4
Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration
201224 citationsauthor #9
Abstract A18: Reduced NF1 expression in resistance to EGF receptor inhibitory drugs in lung adenocarcinoma
20120 citationsauthor #3
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target
2012114 citationsauthor #16
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.
2012202 citationsauthor #6
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila
2012105 citationsauthor #9
220 PFKFB4 is Essential for Prostate Cancer Cell Survival by Maintaining the Balance Between the Use of Glucose for Energy Generation and the Synthesis of Anti-oxidants
20121 citationsauthor #6
Abstract A17: Loss of DEPTOR increases resistance to EGFR tyrosine kinase inhibitors by upregulating EGFR and MAPK signaling
20121 citationsauthor #3
The centriolar satellite protein Cep131 is important for genome stability
2012100 citationsauthor #7
Genome‐wide siRNA screen reveals amino acid starvation‐induced autophagy requires SCOC and WAC
2012114 citationsauthor #5
Chromosomal instability confers intrinsic multidrug resistance.
2011457 citationsauthor #11
Tales from an academic RNAi screening facility; FAQs.
20118 citationsauthor #5
Abstract LB-398: Identification of novel mechanisms of resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer
20110 citationsauthor #3
SNW1 Is a Critical Regulator of Spatial BMP Activity, Neural Plate Border Formation, and Neural Crest Specification in Vertebrate Embryos
201147 citationsauthor #3
PKCα and PKCδ Regulate ADAM17-Mediated Ectodomain Shedding of Heparin Binding-EGF through Separate Pathways
201155 citationsauthor #4
220 Identification of resistance mechanisms to EGFR inhibitors in non-small cell lung cancer cells
20101 citationsauthor #3
Cytoplasmic TDP-43 accumulation is related to nuclear transport dysfunction in frontotemporal lobar degeneration and motor neuron disease
20100 citationsauthor #7
Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets
201044 citationsauthor #7
Manipulating signal delivery – plasma-membrane ERK activation in aPKC-dependent migration
201026 citationsauthor #3
Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration.
2010192 citationsauthor #6
Chromosomal instability determines taxane sensitivity - supplementary materials
20090 citationsauthor #16
Chromosomal instability determines taxane response
2009275 citationsauthor #16
Two highly related regulatory subunits of PP2A exert opposite effects on TGF-β/Activin/Nodal signalling
200880 citationsauthor #6
Arkadia Activates Smad3/Smad4-Dependent Transcription by Triggering Signal-Induced SnoN Degradation
2007178 citationsauthor #2
Kinesin-mediated transport of Smad2 is required for signaling in response to TGF-beta ligands.
200789 citationsauthor #2
Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling.
200717 citationsauthor #3
Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription
2006158 citationsauthor #4
Recognition of Phosphorylated-Smad2-Containing Complexes by a Novel Smad Interaction Motif
200466 citationsauthor #2
A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements.
200243 citationsauthor #1
Xenopus Smad3 is specifically expressed in the chordoneural hinge, notochord and in the endocardium of the developing heart.
200128 citationsauthor #1
Signalling to the nucleus by TGF-β family members and regulation of transcription
20000 citationsauthor #3
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif.
2000281 citationsauthor #2
XSmad2 directly activates the activin‐inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos
199773 citationsauthor #1

TIMELINE

1997 73 citations

2000 281 citations

2001 28 citations

2002 43 citations

2004 66 citations

2006 158 citations

2007 284 citations

2008 80 citations

2009 275 citations

2010 263 citations

2011 567 citations

2012 667 citations

2013 913 citations

2014 189 citations

2015 877 citations

2016 268 citations

2017 399 citations

2018 496 citations

2019 258 citations

2020 199 citations

2021 972 citations

2022 8 citations

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