J. Trudeau

PROFILE

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Aliases
John B. Trudeau, John Trudeau, J B Trudeau, J. B. Trudeau, John B Trudeau
Publication record
98 papers · 5,704 citations · H-index 34

PAPERS

PrecISE- A Biomarker Stratified Adaptive Trial of 5 Interventions in Severe Asthma: Final Protocol and the Baseline Cohort.
20260 citationsauthor #256
Airway Epithelial Heterogeneity and Mucus Plugging in Asthmatic Bronchioles.
20250 citationsauthor #21
Corrigendum to High IFN-γ and low SLPI mark severe asthma in mice and humans
20250 citationsauthor #6
Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes
202421 citationsauthor #14
High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status
202149 citationsauthor #7
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation
202171 citationsauthor #11
Baseline sputum eosinophil+neutrophil subgroups' clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) Cohort.
202029 citationsauthor #32
Oxidative Stress, as Measured by Gene Expression and Airway Glutathione, Is Increased in Severe Asthma and Associated with Racial Background
20200 citationsauthor #3
Mucociliary Clearance (MCC) in Mild-Asthma Without Inhaled Corticosteroid Treatment Is Inversely Proportional to Exhaled Nitric Oxide
20200 citationsauthor #6
CERAMIDE IN APOPTOSIS AND OXIDATIVE STRESS IN ALLERGIC INFLAMMATION AND ASTHMA.
202062 citationsauthor #11
Age of Asthma Onset, not Severity, Predicts Environmental Allergy Clusters
20200 citationsauthor #4
PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells
202087 citationsauthor #12
BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and In ﬂ uences of Medications
201918 citationsauthor #16
High IFN-g and low SLPI mark severe asthma in mice and humans
201921 citationsauthor #6
Bronchoalveolar Lavage Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications.
201925 citationsauthor #15
Regulation of the Intracellular Glutathione Redox State in Asthma
20190 citationsauthor #3
Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation.
201924 citationsauthor #12
Nasal polyps 15-lipoxygenase 1 promotes CCL26/Eotaxin3 expression through ERK activation.
201947 citationsauthor #6
Dysfunctional ErbB2, an EGF receptor family member, in asthmatic airway epithelial cells critically hinders repair after mechanical wounding
20191 citationsauthor #6
Dysfunctional ErbB2, an EGF receptor family member, hinders repair of airway epithelial cells from asthmatic patients.
201926 citationsauthor #6
Location of Pulmonary Mast Cells Predicts Asthma Outcomes: 899
20190 citationsauthor #3
IL‐4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL‐25 Signaling
201710 citationsauthor #7
Airway Mast Cells on a Type-2 Inflammatory Background Confer a More Clinically Severe Asthma Phenotype Than Isolated Type-2 Inflammation
20170 citationsauthor #2
IL-13 induces glucocorticoid resistance in iNOS expression and activity in human airway epithelial cells (HAECs)
20170 citationsauthor #5
Non Type-2 Severe Asthma Has Increased Bronchoalveolar Mast Cell Mediator Release and Health Care Utilization
20160 citationsauthor #2
IL-27 and Type-2 immunity in asthma: Association with severity, CXCL9 and STAT signaling
20152 citationsauthor #4
IL-27 and type 2 immunity in asthmatic patients: association with severity, CXCL9, and signal transducer and activator of transcription signaling.
201544 citationsauthor #4
High IFN-γ and low SLPI mark severe asthma in mice and humans.
2015287 citationsauthor #6
Brain-Derived Neurotrophic Factor Expression in Asthma. Association with Severity and Type 2 Inflammatory Processes.
201547 citationsauthor #3
IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism.
201527 citationsauthor #6
The Complex Relationship Between Inflammation And Lung Function In Severe Asthma
2014101 citationsauthor #2
High Blood Eosinophils Predict Reductions In Sputum Mast Cells and Lung Function In Response To Triamcinolone In Asthma
20140 citationsauthor #3
A Web-Accessible Computer Application (“App” for Temperature Adjustment of Arterial Blood Gas (ABG) Parameters During Therapeutic Hypothermia
20140 citationsauthor #3
An Airway Epithelial iNOS-DUOX2-Thyroid Peroxidase Metabolome Drives Th1/Th2 Nitrative Stress in Human Severe Asthma
2014245 citationsauthor #14
P6: Th1/Th2 Cytokines promote Nitrite/H2O2-mediated tyrosine nitration in airway epithelial cells: Potential role in severe asthma
20134 citationsauthor #3
Prostaglandin D₂ pathway upregulation: relation to asthma severity, control, and TH2 inflammation.
2013207 citationsauthor #5
Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset
201291 citationsauthor #6
Epithelial Dual Oxidases (Duox1 And Duox2) Are Increased In Severe Asthma
20120 citationsauthor #2
Loss Of Stem Cell Factor Expressing Epithelial Cells To The Airway Lumen: A Risk For Severe And Poorly Controlled Asthma
20122 citationsauthor #2
15-Lipoxygenase 1 Regulates LC3 Expression/Activation In Asthmatic Airway Epithelial Cells
20120 citationsauthor #3
Induced Sputum Bronchoepithelial Cells Associate With Asthma Severity In Children: Data From The Severe Asthma Research Program (SARP)
20120 citationsauthor #4
Functional Differences in Bronchoalveolar Lavage (BAL) Mast Cells (MCs) in Severe and Mild Asthma
20120 citationsauthor #2
Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation
201274 citationsauthor #4
Airway Epithelial Eosinophilia Is Associated With Asthma And Better Predicts Severity Than Sputum Or BAL Eosinophils
20120 citationsauthor #2
MAPK Regulation of IL-4/IL-13 Receptors Contributes to the Synergistic Increase in CCL11/Eotaxin-1 in Response to TGF-β1 and IL-13 in Human Airway Fibroblasts
201244 citationsauthor #4
Epithelial Microarray Studies From The Severe Asthma Research Program (SARP)
20120 citationsauthor #5
Epithelial Human Epidermal Growth Factor Receptor 2 (ErbB2) Is Increased In Severe Asthma
20121 citationsauthor #2
Reduced L-Arginine/ADMA As A Potential Mechanism To Explain Increased Symptom Severity And Reduced Atopy In Late Onset Obese Asthmatics
20126 citationsauthor #5
Prolonged 15LO1 Expression And Activation Sustains A Th2 Epithelial Signature
20120 citationsauthor #4
15-Lipoxygenase 1 Interacts With PEBP1 To Regulate MEK/ERK Pathway In Asthmatic Airway Epithelial Cells
20111 citationsauthor #5
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells
2011132 citationsauthor #5
Increased Expression Of Eotaxin-2 In The Airway Epithelium Correlates With Airway Eosinophilia And Severity Of Asthma
20110 citationsauthor #2
15LO1 Stability And Activity Induced By IL-13 In Human Airway Epithelial Cells
20110 citationsauthor #6
CRTH2 Receptor And Its Ligand, PGD2, Are Increased In Severe Asthma
20111 citationsauthor #3
Sputum Mast Cell Markers Reflect Invasive Measures and Represent a Noninvasive Biologic Marker of Asthma Control and Severity
20110 citationsauthor #4
TGF-β2/TGF-β1 mRNA Expression From Human Bronchial Epithelial Cells is Greater in Asthmatics than Normal Controls and has a Negative Correlation with Baseline FEV1
20100 citationsauthor #2
Elevated Prostaglandin D2 (PGD2) Levels in Bronchoalveolar Lavage Fluid (BALF) in Severe Asthma
20103 citationsauthor #3
Identification Of Multiple Transcription Factors Induced By IL-13 In Human Airway Epithelial Cell Using Protein/DNA Array
20100 citationsauthor #2
Increased Eotaxin-2 MRNA Expression In The Broncho-epithelial Cells Of Asthmatics Correlates With Eosinophilia And Clinical Severity Of Asthma
20100 citationsauthor #3
Severe African American Asthmatics Have Lower Vitamin D Levels When Compared To Severe Caucasian Asthmatics
20101 citationsauthor #3
Epithelial Hematopoietic Prostaglandin (PG) D Synthase Is Increased In Asthma
20101 citationsauthor #3
Inducible Nitric Oxide Synthase (iNOS) And Nitrotyrosine Levels In Bronchial Epithelial Cells Predict Asthma Severity
20100 citationsauthor #2
Increased Evidence For Autophagy In Human Bronchial Epithelial Cells (HBECs)
20100 citationsauthor #2
Increased Eotaxin-2 mRNA in Asthmatic Bronchial Epithelial Cells Ex Vivo: Correlations with Clinical/Inflammatory Parameters.
20090 citationsauthor #3
Early Onset (EO) Severe Asthma (SA) Is Associated with Sputum Neutrophilia, While Late Onset (LO) SA Is Associated with a Range of Inflammatory Subtypes.
20091 citationsauthor #2
Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells.
2009111 citationsauthor #7
IL-4Rα Induced PI3K Limits Eotaxin-1 Expression through Effects on the STAT-6 Pathway in Primary Human Airway Fibroblasts.
20090 citationsauthor #3
Increased Apoptosis Contributes to Decreased Viral Titers in Human Bronchial Epithelial Cells (HBEC) Exposed to Rhinovirus-16 (RV-16).
20090 citationsauthor #5
Increased Mast Cell Adhesion Molecule Immunoglobulin Super Family 4 (IGSF4) in Distal Lung Fibroblasts: Regulation by Transforming Growth Factor-ß2
20080 citationsauthor #3
IL‐13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells
200811 citationsauthor #2
IL‐13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells
2008205 citationsauthor #2
Effect of IL-13 on Thymic Stromal Lymphopoietin in Human Bronchial Epithelial Cells
20081 citationsauthor #3
IL-13 induced MUC5AC is regulated by 15-Lipoxygenase (LO) 1 Pathway in Human Bronchial Epithelial Cells
20082 citationsauthor #5
Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts.
200736 citationsauthor #6
Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13.
200672 citationsauthor #1
Regional fibroblast heterogeneity in the lung: implications for remodeling.
200697 citationsauthor #3
Increased TGF-beta2 in severe asthma with eosinophilia.
200561 citationsauthor #5
Interleukin-13 augments transforming growth factor-beta1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts.
200534 citationsauthor #2
Increased TGF-β2 in severe asthma with eosinophilia
2005126 citationsauthor #5
Sputum dysplasia, related to bacterial load, oxidative stress, and airway inflammation in COPD.
20041 citationsauthor #3
Distinguishing asthma phenotypes: Role of age of onset and eosinophilic inflammation
20041 citationsauthor #4
Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation.
2004592 citationsauthor #4
Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma.
2004146 citationsauthor #5
Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids.
2003157 citationsauthor #4
The relationship of induced-sputum inflammatory cells to BAL and biopsy.
200316 citationsauthor #2
Expression and activation of 15‐lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition
2002169 citationsauthor #4
Fibroblasts Eotaxin-1 Production in Human Airway and IL-13 Synergistically Increase β TGF-Hong
20020 citationsauthor #6
TGF-β and IL-13 Synergistically Increase Eotaxin-1 Production in Human Airway Fibroblasts1
2002119 citationsauthor #2
Persistent wheezing in very young children is associated with lower respiratory inflammation.
2001218 citationsauthor #5
Mechanisms of allergy Peripheral blood and airway tissue expression of transforming growth factor β by neutrophils in asthmatic subjects and normal control subjects
20000 citationsauthor #2
Peripheral blood and airway tissue expression of transforming growth factor beta by neutrophils in asthmatic subjects and normal control subjects.
2000109 citationsauthor #2
Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics.
19991,256 citationsauthor #5
Theophylline: potential antiinflammatory effects in nocturnal asthma.
199684 citationsauthor #3
541 RANTES levels and eosinophils increase in broncoalveolar lavage fluid (BALF) after indomethacin in aspirin-intolerant asthmatics (AIA)
19960 citationsauthor #3
Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma.
1995232 citationsauthor #2
Single oral dose of prednisone decreases leukotriene B4 production by alveolar macrophages from patients with nocturnal asthma but not control subjects: relationship to changes in cellular influx and FEV1.
199434 citationsauthor #2
Peritoneal lavage fluid alters patterns of eicosanoid production in murine bone marrow-derived and peritoneal macrophages: Dependency on inflammatory state of the peritoneum
19935 citationsauthor #2
Transforming Growth Factor-(cid:2) 2 Induces Bronchial Epithelial Mucin Expression in Asthma
year unknown0 citationsauthor #6

TIMELINE

1993 5 citations

1994 34 citations

1995 232 citations

1996 84 citations

1999 1,256 citations

2000 109 citations

2001 218 citations

2002 288 citations

2003 173 citations

2004 740 citations

2005 221 citations

2006 169 citations

2007 36 citations

2008 219 citations

2009 112 citations

2010 5 citations

2011 134 citations

2012 218 citations

2013 211 citations

2014 346 citations

2015 407 citations

2016 0 citations

2017 10 citations

2019 162 citations

2020 178 citations

2021 120 citations

2024 21 citations

2025 0 citations

2026 0 citations

Unknown 0 citations

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