W. Geissler

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Aliases
Wayne M. Geissler, Wayne M Geissler, W. Geissler, W Geissler, W M Geissler, Wayne Geissler
Publication record
40 papers · 1,842 citations · H-index 17

PAPERS

Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization.
202098 citationsauthor #4
Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants.
20208 citationsauthor #6
Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].
20170 citationsauthor #8
Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target
201618 citationsauthor #4
Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.
201623 citationsauthor #8
Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
201616 citationsauthor #14
Rapid development of two factor IXa inhibitors from hit to lead.
201516 citationsauthor #19
Development of a novel class of potent and selective FIXa inhibitors.
201517 citationsauthor #7
Development of a novel tricyclic class of potent and selective FIXa inhibitors.
201512 citationsauthor #10
Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
201310 citationsauthor #13
Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
20127 citationsauthor #13
Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
201211 citationsauthor #14
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
20127 citationsauthor #9
The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.
201215 citationsauthor #12
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
20126 citationsauthor #10
Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
201119 citationsauthor #13
Enzymatic preparation of high-specific-activity beta-D-[6,6'-3H]fructose-2,6-bisphosphate: Application to a sensitive assay for fructose-2,6-bisphosphatase.
20105 citationsauthor #4
Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
201051 citationsauthor #10
Expression, purification and crystallization of human prolylcarboxypeptidase.
201020 citationsauthor #10
Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase
20100 citationsauthor #8
Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase
201017 citationsauthor #8
Identification of peptidase substrates in human plasma by FTMS based differential mass spectrometry
200715 citationsauthor #3
Modeling aided design of potent glycogen phosphorylase inhibitors.
200512 citationsauthor #6
Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism.
200421 citationsauthor #15
Novel 3,4‐Dihydroquinolin‐2(1H)‐one Inhibitors of Human Glycogen Phosphorylase a.
20042 citationsauthor #5
Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.
200333 citationsauthor #5
Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.
200360 citationsauthor #5
A new class of glycogen phosphorylase inhibitors.
200334 citationsauthor #6
Allosteric Effects of Dexamethasone and RU486 on Glucocorticoid Receptor-DNA Interactions*
200247 citationsauthor #2
Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics.
200244 citationsauthor #3
The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.
200181 citationsauthor #4
HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO
20010 citationsauthor #4
Cloning and expression of Staphylococcus aureus and Treptococcus pyogenes murD genes encoding uridine diphosphate N-acetylmuramoyl-L-alanine:D-glutamate ligases.
199815 citationsauthor #2
Hepatic responses to inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase: a comparison of atorvastatin and simvastatin.
199844 citationsauthor #4
2.P.24 Responses to the inhibition of HMG-CoA reductase: A comparison of simvastatin and atorvastatin
19972 citationsauthor #4
Immunohistochemical Analysis of Steroid 5α‐Reductase Type 1 in Human Scalp and Prostate
199615 citationsauthor #3
Immunohistochemical analysis of steroid 5 alpha-reductase type 1 in human scalp and prostate.
19965 citationsauthor #3
The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases.
19955 citationsauthor #2
Male pseudohermaphroditism caused by mutations of testicular 17β–hydroxysteroid dehydrogenase 3
1994590 citationsauthor #1
Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.
1993442 citationsauthor #3

TIMELINE

1993 442 citations

1994 590 citations

1995 5 citations

1996 20 citations

1997 2 citations

1998 59 citations

2001 81 citations

2002 91 citations

2003 127 citations

2004 23 citations

2005 12 citations

2007 15 citations

2010 93 citations

2011 19 citations

2012 46 citations

2013 10 citations

2015 45 citations

2016 57 citations

2017 0 citations

2020 106 citations

W. Geissler

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