F. Trejtnar

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F Trejtnar, F. Trejtnar, Frantisek Trejtnar, František Trejtnar
Publication record
97 papers · 1,466 citations · H-index 20

PAPERS

Evaluation of pharmacokinetics, pharmacodynamics, and toxicity of potential quinazoline bronchodilators derived from vasicinone.
20250 citationsauthor #15
Terbium-161 in nuclear medicine: Preclinical and clinical progress in comparison with lutetium-177.
20257 citationsauthor #1
5-(3,5-Dinitrophenyl)-1,3,4-oxadiazol-2-amine derivatives, their precursors, and analogues: Synthesis and evaluation of novel highly potent antitubercular agent
20252 citationsauthor #10
Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model
20240 citationsauthor #8
Improving the antimicrobial activity of old antibacterial drug mafenide: Schiff bases and their bioactivity targeting resistant pathogens.
20238 citationsauthor #9
Validation of Freshly Isolated Rat Renal Cells as a Tool for Preclinical Assessment of Radiolabeled Receptor-Specific Peptide Uptake in the Kidney
20232 citationsauthor #5
Implementing reversed-phase and hydrophilic interaction liquid chromatography into the characterization of DTPA-ramucirumab conjugate before radiolabeling.
20231 citationsauthor #3
Preparation, In Vitro Affinity, and In Vivo Biodistribution of Receptor-Specific 68Ga-Labeled Peptides Targeting Vascular Endothelial Growth Factor Receptors.
20229 citationsauthor #9
Preclinical evaluation of [89Zr]Zr-ramucirumab: the monoclonal antibody for imaging of VEGFR2 positive tumors
20220 citationsauthor #6
Comprehensive insight into anti-staphylococcal and anti-enterococcal action of brominated and chlorinated pyrazine-based chalcones
20229 citationsauthor #9
Optimizing the structure of (salicylideneamino)benzoic acids: Towards selective antifungal and anti-staphylococcal agents.
20219 citationsauthor #5
Highly stereocontrolled total synthesis of racemic codonopsinol B through isoxazolidine-4,5-diol vinylation
20210 citationsauthor #3
Design and Synthesis of Highly Active Antimycobacterial Mutual Esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic Acid
20212 citationsauthor #6
Novel Aminoguanidine Hydrazone Analogues: From Potential Antimicrobial Agents to Potent Cholinesterase Inhibitors
202118 citationsauthor #8
Preclinical evaluation of anti-VEGFR2 monoclonal antibody ramucirumab labelled with zirconium-89 for tumour imaging.
20216 citationsauthor #6
Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents.
202122 citationsauthor #7
New total synthesis and structure confirmation of putative (+)-hyacinthacine C3 and (+)-5-epi-hyacinthacine C3
20211 citationsauthor #8
Sulfonamide-salicylaldehyde imines active against methicillin- and trimethoprim/sulfonamide-resistant Staphylococci.
202111 citationsauthor #7
New hybrids of tacrine and indomethacin as multifunctional acetylcholinesterase inhibitors
20207 citationsauthor #5
18 Anniversary Conference 20 Years Cyprus Society Of Nuclear Medicine (CYSNM20) Limassol Cyprus, 6th– 10th November 2019
20190 citationsauthor #23
Antiangiogenic Human Monoclonal Antibody Ramucirumab Radiolabelling: In Vitro Evaluation on VEGFR2-positive Cell Lines
20195 citationsauthor #5
Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors.
201939 citationsauthor #7
4-Aminobenzoic Acid Derivatives: Converting Folate Precursor to Antimicrobial and Cytotoxic Agents
201968 citationsauthor #6
Interaction of soy isoflavones and their main metabolites with hOATP2B1 transporter
20184 citationsauthor #6
Honey flavonoids inhibit hOATP2B1 and hOATP1A2 transporters and hOATP-mediated rosuvastatin cell uptake in vitro
201817 citationsauthor #5
Correction to: Interaction of soy isoflavones and their main metabolites with hOATP2B1 transporter
20186 citationsauthor #6
New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action.
201834 citationsauthor #10
Corrigendum to "Novel salicylanilides from 4,5-dihalogenated salicylic acids: Synthesis, antimicrobial activity and cytotoxicity" [Bioorg. Med. Chem. 25 (2017) 1524-1532].
20172 citationsauthor #6
3-Substituted N-Benzylpyrazine-2-carboxamide Derivatives: Synthesis, Antimycobacterial and Antibacterial Evaluation
201712 citationsauthor #6
Sulfadiazine Salicylaldehyde-Based Schiff Bases: Synthesis, Antimicrobial Activity and Cytotoxicity
201788 citationsauthor #5
In vitro evaluation of concentration, labeling effectiveness and stability for 131 I-labeled radioimmunoassay ligand using real-time detection technology.
20173 citationsauthor #4
Synthesis of readily available fluorophenylalanine derivatives and investigation of their biological activity.
20179 citationsauthor #5
Novel salicylanilides from 4,5-dihalogenated salicylic acids: Synthesis, antimicrobial activity and cytotoxicity.
201720 citationsauthor #6
Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation.
201717 citationsauthor #3
Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug–Drug Interactions
201617 citationsauthor #9
The pregnane X receptor down‐regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (“squelching”) SRC‐1 coactivator
201636 citationsauthor #6
Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation
201623 citationsauthor #3
The involvement of selected membrane transport mechanisms in the cellular uptake of (177)Lu-labeled bombesin, somatostatin and gastrin analogues.
20158 citationsauthor #6
Synthesis and antimicrobial activity of sulphamethoxazole-based ureas and imidazolidine-2,4,5-triones
20157 citationsauthor #3
Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity.
201515 citationsauthor #4
Design, synthesis and anti-mycobacterial evaluation of some new N-phenylpyrazine-2-carboxamides
20156 citationsauthor #5
The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with (177) Lu.
20152 citationsauthor #6
Cover Picture: Bisamidate Prodrugs of 2‐Substituted 9‐[2‐(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis (ChemMedChem 8/2015)
20150 citationsauthor #8
Bisamidate Prodrugs of 2‐Substituted 9‐[2‐(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis
201517 citationsauthor #8
Renal Handling of Amphotericin B and Amphotericin B-Deoxycholate and Potential Renal Drug-Drug Interactions with Selected Antivirals
20148 citationsauthor #1
The effect of chelator type on in vitro receptor binding and stability in 177Lu-labeled cetuximab and panitumumab.
20148 citationsauthor #6
How to address the sample preparation of hydrophilic compounds: Determination of entecavir in plasma and plasma ultrafiltrate with novel extraction sorbents.
201419 citationsauthor #4
Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity.
201418 citationsauthor #6
Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa
201411 citationsauthor #10
The renal handling of amphotericin B and amphotericin B / deoxycholate and potential 1 renal drug-drug interactions with selected antivirals 2 3
20140 citationsauthor #1
Application of Automatic Radioimmunoassay to Facilitate In Vitro Tracer Development
20140 citationsauthor #4
Determination of receptor protein binding site specificity and relative binding strength using a time-resolved competition assay.
20142 citationsauthor #5
Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates.
201433 citationsauthor #4
Exploring Time-Resolved Characterization of the Heterogeneity and Dynamics of Ligand-Receptor Interactions on Living Cells
201411 citationsauthor #3
Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.
201345 citationsauthor #11
Modulatory Effects of Quercetin and Rutin on the Activity, Expression and Inducibility of CYP1A1 in Intestinal HCT‐8 Cells
201313 citationsauthor #4
Preclinical Evaluation of Ligand-Target Binding Properties Using Competitive Interaction Analysis in Real-Time Radioimmunoassay on Living Cells
20130 citationsauthor #2
Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates
201344 citationsauthor #5
Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.
201318 citationsauthor #7
A resurrection of 7-MEOTA: a comparison with tacrine.
201394 citationsauthor #11
Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution.
201319 citationsauthor #5
Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2'-hydroxybenzanilides, their thioxo analogues and benzoxazoles.
201220 citationsauthor #5
Iron reduction potentiates hydroxyl radical formation only in flavonols.
201263 citationsauthor #6
A comparison of in vitro methods for determining the membrane receptor expression in cell lines.
201216 citationsauthor #5
Distribution, Elimination, and Renal Handling of 99mTechnetium-Demogastrin 1
20121 citationsauthor #1
Highly sensitive fast determination of entecavir in rat urine by means of hydrophilic interaction chromatography-ultra-high-performance liquid chromatography-tandem mass spectrometry.
201221 citationsauthor #4
Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues.
201210 citationsauthor #5
Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase.
201274 citationsauthor #6
Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxybenzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold.
201289 citationsauthor #5
Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model.
20111 citationsauthor #3
Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs
20119 citationsauthor #3
Biodistribution of two octreotate analogs radiolabeled with indium and yttrium in rats.
20106 citationsauthor #3
Distribution and elimination characteristics of111In-DTPA-D-Phe1-octreotide and111In-DTPA-L-Phe1-octreotide in rats
20106 citationsauthor #3
In vitro comparison of renal handling and uptake of two somatostatin receptor-specific peptides labeled with indium-111
200810 citationsauthor #1
Azole Antimycotics Differentially Affect Rifampicin-Induced Pregnane X Receptor-Mediated CYP3A4 Gene Expression
200861 citationsauthor #7
Pregnane X Receptor (PXR)-mediated CYP3A4 gene expression
20070 citationsauthor #7
Biodistribution and elimination characteristics of two 111In-labeled CCK-2/gastrin receptor-specific peptides in rats.
200715 citationsauthor #1
99mTc demotate 1: biodistribution and elimination characteristics in rats
20053 citationsauthor #2
Analysis of accumulation of 99mTc-octreotide and 99mTc-EDDA/HYNIC-Tyr3-octreotide in the rat kidneys.
200412 citationsauthor #3
Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs.
20039 citationsauthor #1
Comparison of 99mTc-mercaptoacetyltriglycine and [131I]-o-iodohippurate elimination in perfused rat kidney.
20031 citationsauthor #1
Lanreotide labeled with 99mTc: preparation, preclinical testing and comparison with (111)In-DTPA-octreotide.
20026 citationsauthor #3
Analysis of renal handling of radiopharmaceuticals.
200235 citationsauthor #1
Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: phase I of biotransformation.
200112 citationsauthor #5
Radiolabelled yttrium complexes with octreotide, Tyr3-octreotide and vapreotide (RC-160): Distribution in rats
20000 citationsauthor #3
Pharmacokinetics and renal handling of 99mTc-labeled peptides.
200026 citationsauthor #1
Pharmacokineticsand Renal Handling of 99@Tc-Labeled Peptides
20000 citationsauthor #1
Preclinical comparison of octreotide radiolabelled with indium and yttrium
20000 citationsauthor #3
Sex differences in stereospecificity of oracin reductases in rat in vitro and in vivo.
199914 citationsauthor #4
Use of rat hepatocytes immobilized in agarose gel threads for biosynthesis of metabolites of potential cytostatics.
19992 citationsauthor #1
Metabolic pathways of flobufen-a new antirheumatic and antiarthritic drug. Interspecies comparison.
19999 citationsauthor #4
Stereoselective pharmacokinetics of flobufen in rats.
19999 citationsauthor #1
Study of the biotransformation of a potential benzo[c]fluorene antineoplastic using high-performance liquid chromatography with high-speed-scanning ultraviolet detection.
199614 citationsauthor #8
Possible use of excretion of tubular epithelial cells for the study of the nephrotoxic effect of xenobiotics.
19965 citationsauthor #2
P227 enzymic and chromatographic characterization of the in vitro metabolites of the potential cytostatic oracine
19940 citationsauthor #4
N-demethylation activity of renal and hepatic subcellular fractions: an interspecies comparison.
19910 citationsauthor #1
Effects of Anethum Graveolens Ethanolic Extract on T3, T4, and TSH Levels in a Hyperthyroid Rat Model
year unknown0 citationsauthor #47

TIMELINE

1991 0 citations

1994 0 citations

1996 19 citations

1999 34 citations

2000 26 citations

2001 12 citations

2002 41 citations

2003 10 citations

2004 12 citations

2005 3 citations

2007 15 citations

2008 71 citations

2010 12 citations

2011 10 citations

2012 294 citations

2013 233 citations

2014 110 citations

2015 55 citations

2016 76 citations

2017 151 citations

2018 61 citations

2019 112 citations

2020 7 citations

2021 69 citations

2022 18 citations

2023 11 citations

2024 0 citations

2025 9 citations

Unknown 0 citations

F. Trejtnar

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