J. Näslund

PROFILE

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Aliases
Jan E Näslund, Jan Näslund, Jan Näslund, J. Näslund, J Näslund
Publication record
96 papers · 9,132 citations · H-index 37

PAPERS

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing
20192 citationsauthor #7
The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing
20180 citationsauthor #7
Bone and Soft Tissue Blood Flow during Normobaric and Hyperbaric Oxygen Breathing in Healthy Divers
20141 citationsauthor #3
Commentary Is Placebo AcupunctureWhat It Is Intended to Be ?
20146 citationsauthor #4
The needling sensation: A factor contributing to the specific effects of acupuncture?
201213 citationsauthor #3
findings''examination, MRI and ultrasound patellofemoral pain: aggravating activities, MRI and ultrasound findingsAcute aggravating activities, clinical examination, Commentary on ''Acute patellofemoral pain:
20120 citationsauthor #1
Is compassion a part of the non-specific effects of acupuncture?
20120 citationsauthor #3
Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions.
201249 citationsauthor #4
Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing*
201118 citationsauthor #6
In Search of the Etiology of Anterior Knee Pain
20115 citationsauthor #1
Is Placebo Acupuncture What It Is Intended to Be?
2011125 citationsauthor #4
Bone blood flow is influenced by muscle contractions
201113 citationsauthor #1
Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.
201150 citationsauthor #6
THE LARGE HYDROPHILIC LOOP OF PRESENILIN 1 IS IMPORTANT FOR REGULATING γ -SECRETASE COMPLEX ASSEMBLY AND DICTATING THE A β PROFILE WITHOUT AFFECTING NOTCH PROCESSING
20100 citationsauthor #7
The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing*
201016 citationsauthor #8
Minimal Acupuncture is not a Valid Placebo Control in Randomised Controlled Trials of Acupuncture: A Physiologist’s Perspective
200912 citationsauthor #2
Minimal acupuncture is not a valid placebo control in randomised controlled trials of acupuncture: a physiologist's perspective
2009239 citationsauthor #2
P4‐038: Transgenic mice with the Arctic APP mutation show an age‐dependent increase in Aβ levels
200924 citationsauthor #7
P4‐198: Molecular studies of the presenilin protein interactions to γ‐secretase inhibitors and modulators
20080 citationsauthor #4
P1‐108: No detectable behavioural abnormality in arctic APP transgenic mice: Behaviour study in a mouse model of Alzheimer's disease
20080 citationsauthor #6
O4‐03–05: A molecular investigation of different domains in the gamma‐secretase complex for their substrate interaction
20081 citationsauthor #4
Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease.
2008107 citationsauthor #5
AIM December 2008 Text.qxd
200890 citationsauthor #3
P3‐347: Molecular studies of the gamma‐secretase complex: Focus on nicastrin
20080 citationsauthor #4
γ-Secretase: a complex target for Alzheimer's disease
200755 citationsauthor #2
Unwinding fibril formation of medin, the peptide of the most common form of human amyloid.
200740 citationsauthor #7
The Alzheimer's disease-associated γ-secretase complex: Functional domains in the presenilin 1 protein
200723 citationsauthor #3
Commentary on “Acute patellofemoral pain: aggravating activities, clinical examination, MRI and ultrasound findingsAcute patellofemoral pain: aggravating activities, clinical examination, MRI and ultrasound findings”
20073 citationsauthor #1
Stable insertion of Alzheimer Aβ peptide into the ER membrane strongly correlates with its length
20078 citationsauthor #4
Gamma-secretase: a complex target for Alzheimer's disease.
200717 citationsauthor #2
Acupuncture – Self-Appraisal and the Reward System
200755 citationsauthor #3
Decreased Pulsatile Blood Flow in the Patella in Patellofemoral Pain Syndrome
200740 citationsauthor #1
Comparison of symptoms and clinical findings in subgroups of individuals with patellofemoral pain
200670 citationsauthor #1
Analysis of single Alzheimer solid plaque cores by laser capture microscopy and nanoelectrospray/tandem mass spectrometry.
200636 citationsauthor #5
Patellofemoral pain syndrome : Clinical and pathophysiological considerations
200611 citationsauthor #1
AbstractPoster presentation: Wednesday posterP4-019: Positive correlation of brain zinc with Alzheimer’s disease β-amyloid burden
20060 citationsauthor #6
Non-invasive continuous estimation of blood flow changes in human patellar bone
200660 citationsauthor #1
Elevated cortical zinc in Alzheimer disease
2006271 citationsauthor #7
Characterization of the Alzheimer's Disease-associated CLAC Protein and Identification of an Amyloid β-Peptide-binding Site*
200531 citationsauthor #7
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
2005915 citationsauthor #14
Decreased levels of amyloid beta peptide in the brains of smokers
20050 citationsauthor #8
A Nine-transmembrane Domain Topology for Presenilin 1*
2005213 citationsauthor #9
Aph‐1 interacts at the cell surface with proteins in the active γ‐secretase complex and membrane‐tethered Notch
200530 citationsauthor #5
CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation.
20059 citationsauthor #6
γ‐Secretase complexes containing N‐ and C‐terminal fragments of different presenilin origin retain normal γ‐secretase activity
200516 citationsauthor #5
CLAC Binds to Aggregated Aβ and Aβ Fragments, and Attenuates Fibril Elongation
200527 citationsauthor #6
Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates
200538 citationsauthor #7
Diffusely increased bone scintigraphic uptake in patellofemoral pain syndrome
200547 citationsauthor #1
Macroautophagy—a novel (cid:1) -amyloid peptide-generating pathway activated in Alzheimer’s disease
20050 citationsauthor #14
patellofemoral pain syndrome Diffusely increased bone scintigraphic uptake in
20050 citationsauthor #1
P1-185 Analysis of single Alzheimer plaque cores by laser-capture microscopy and nano-electrospray/tandem mass spectrometry
20040 citationsauthor #5
P4-171 Molecular and biochemical characterization of presenilin-1 and presenilin-2-γ-secretase complexes in post-mortem human brain
20040 citationsauthor #5
FUNCTIONAL DOMAINS IN PRESENILIN 1: the Tyr-288 residue controls secretase activity and endoproteolysis
20042 citationsauthor #8
P4-297 Functional domains in presenilin 1: the TYR-288 residue controls gamma-secretas activity and endoproteolysis
20041 citationsauthor #8
Characterization of long‐term mouse brain aggregating cultures: Evidence for maintenance of neural precursor cells
200423 citationsauthor #7
Functional Domains in Presenilin 1
200415 citationsauthor #8
Studies on the γ-Secretase Complex and Processing of the Alzheimer ’ s Disease-associated Amyloid Precursor Protein
20040 citationsauthor #3
The Extreme C Terminus of Presenilin 1 Is Essential for γ-Secretase Complex Assembly and Activity*
200449 citationsauthor #5
Co‐expressed presenilin 1 NTF and CTF form functional γ‐secretase complexes in cells devoid of full‐length protein
200451 citationsauthor #11
Pen-2 Is Sequestered in the Endoplasmic Reticulum and Subjected to Ubiquitylation and Proteasome-mediated Degradation in the Absence of Presenilin*
200480 citationsauthor #8
P1-233 Biochemical characterization of Alzheimer's related CLAC protein and binding to amyloid-β peptide
20040 citationsauthor #5
Amyloid beta pathology in Alzheimer's disease and schizophrenia.
200325 citationsauthor #5
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain*
2003144 citationsauthor #6
Partial purification and characterization of gamma-secretase from post-mortem human brain.
200363 citationsauthor #6
Amyloid β Pathology in Alzheimer’s Disease and Schizophrenia
200346 citationsauthor #5
APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.
200330 citationsauthor #8
Molecular Identification of AMY, an Alzheimer Disease Amyloid‐Associated Protein
200317 citationsauthor #9
Medin and medin‐amyloid in ageing inflamed and non‐inflamed temporal arteries
200239 citationsauthor #3
The Arctic mutation interferes with processing of the amyloid precursor protein
200252 citationsauthor #5
Levels of Total and Deposited Aβ are Correlated with Dementia
20020 citationsauthor #2
Sensory stimulation (acupuncture) for the treatment of idiopathic anterior knee pain.
200250 citationsauthor #1
A Sensitive and Quantitative Assay for Measuring Cleavage of Presenilin Substrates*
2002106 citationsauthor #4
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
20011,239 citationsauthor #11
Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease.
2001198 citationsauthor #6
Molecular consequences of presenilin-1 mutation. Authors' reply
20010 citationsauthor #2
Modes of Sensory Stimulation
20019 citationsauthor #1
Controlling Polymerization of β-Amyloid and Prion-derived Peptides with Synthetic Small Molecule Ligands*
200064 citationsauthor #4
Intraneuronal Aβ42 Accumulation in Human Brain
2000902 citationsauthor #4
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline.
20001,358 citationsauthor #1
Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid.
1999200 citationsauthor #2
Amyloid fibril formation by pulmonary surfactant protein C
1999125 citationsauthor #3
Endogenous Proteins Controlling Amyloid β-Peptide Polymerization
199923 citationsauthor #6
App Localization and Trafficking in the Central Nervous System
19981 citationsauthor #4
Regulation of APP Metabolism by Protein Phosphorylation
19981 citationsauthor #4
Generation of Alzheimer Amyloid β Peptide through Nonspecific Proteolysis*
199735 citationsauthor #2
Controlling Amyloid β-Peptide Fibril Formation with Protease-stable Ligands*
1997220 citationsauthor #4
Molecular mechanisms of A-b amyloid deposition in Alzheimer disease
19960 citationsauthor #1
Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand (*)
1996901 citationsauthor #2
High‐Resolution Separation of Amyloid β‐Peptides: Structural Variants Present in Alzheimer's Disease Amyloid
199628 citationsauthor #1
[A model system in cell culture shows pathogenic processes. Biochemical diagnosis in Alzheimer dementia].
19961 citationsauthor #5
Beta-amyloid protein protein precursor expression in lacrimal glands and tear fluid.
199612 citationsauthor #7
Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.
1995202 citationsauthor #1
[Future drugs against aging? New research on molecular background of aging].
19950 citationsauthor #2
[A breakthrough for research on Alzheimer disease. A model for drug testing].
19950 citationsauthor #2
Human neutrophil phagocytic granules contain a truncated soluble form of the Alzheimer beta/A4 amyloid precursor protein (APP).
199422 citationsauthor #2
A porcine gut polypeptide identical to the pancreatic hormone PP (pancreatic polypeptide)
199411 citationsauthor #5

TIMELINE

1994 33 citations

1995 202 citations

1996 942 citations

1997 255 citations

1998 2 citations

1999 348 citations

2000 2,324 citations

2001 1,446 citations

2002 247 citations

2003 325 citations

2004 221 citations

2005 1,326 citations

2006 448 citations

2007 241 citations

2008 198 citations

2009 275 citations

2010 16 citations

2011 211 citations

2012 62 citations

2014 7 citations

2018 0 citations

2019 2 citations

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