K. Monroe

PROFILE

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Aliases
K M Monroe, K.m. Monroe, Kathryn M Monroe, Kathryn M. Monroe, Kathryn Mcgee Monroe, Kathryn Monroe
Publication record
50 papers · 7,352 citations · H-index 20

PAPERS

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism
20260 citationsauthor #39
Therapeutic targeting of neuroimmune mechanisms in neurodegeneration.
20260 citationsauthor #1
Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques
20254 citationsauthor #22
Anti-Aβ immunotherapy-mediated amyloid clearance attenuates microglial activation without inducing exhaustion at residual plaques
20250 citationsauthor #22
Evaluation of Antibody-Based TREM2 PET in Mice: Contrasting Image-Derived Blood Normalization with the Standard %ID Normalization Method
20250 citationsauthor #10
Blood-Brain Barrier Penetrating Copper-64 TREM2 Antibody Enables Targeted PET Imaging of Tumor-Associated Immune Cells in Glioblastoma Mouse Models
20250 citationsauthor #10
Image-Derived Blood Normalization of Antibody-Based TREM2 PET in Mouse Models of Amyloidosis and Myocardial Infarction
20251 citationsauthor #15
Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.
20252 citationsauthor #51
GPR34 regulates microglia state and loss-of-function rescues TREM2 metabolic dysfunction
20250 citationsauthor #22
PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies
202417 citationsauthor #15
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
20245 citationsauthor #40
Basic Science and Pathogenesis.
20240 citationsauthor #1
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism
20245 citationsauthor #22
Cleaning crew: Soluble TREM2 mops up complement.
20231 citationsauthor #1
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
2023197 citationsauthor #63
Author Correction: Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination
20232 citationsauthor #12
Development of novel 64Cu-labelled antibodies for PET-CT imaging of TREM2
20220 citationsauthor #4
F-18-florbetaben-PET shows distinct distribution patterns of β-amyloid in different knock-in AD mouse models
20220 citationsauthor #10
Quantitative Bioimaging of Microglial Response to Brain-Targeted Treatment Using Deep Learning Based Morphometry
20220 citationsauthor #3
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
202259 citationsauthor #26
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
2021169 citationsauthor #40
Microglia clean up toxic lipids in multiple sclerosis
20215 citationsauthor #1
Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology
20212 citationsauthor #25
Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination
202172 citationsauthor #12
A brain penetrant progranulin biotherapeutic rescues lysosomal and inflammatory phenotypes in the brain of GRN knockout mice
20204 citationsauthor #27
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
2020235 citationsauthor #2
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
2020205 citationsauthor #13
Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease.
2020173 citationsauthor #5
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
2019576 citationsauthor #29
Corrigendum: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
201715 citationsauthor #5
Pyroptosis drives CD4 T-cell depletion in HIV-1 infection
201520 citationsauthor #5
Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells.
2015161 citationsauthor #3
IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV
2014505 citationsauthor #1
Abortively Infected with HIV IFI 16 DNA Sensor Is Required for Death of Lymphoid CD 4 T Cells
20140 citationsauthor #1
F-103 Cell-to-cell transmission of HIV-1 is required to trigger pyroptotic death of CD4 T cells in lymphoid tissue
20140 citationsauthor #6
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.
2013689 citationsauthor #4
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
20131,132 citationsauthor #5
Cell death bypyroptosis drives CD 4 T-cell depletion in HIV-1 infection
20131 citationsauthor #5
Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila.
201327 citationsauthor #3
NLRX1 is a regulator of the innate immune response to influenza A virus infection
20110 citationsauthor #12
STING is a direct innate immune sensor of cyclic-di-GMP
20111,505 citationsauthor #2
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.
2011350 citationsauthor #12
Type I Interferon is Not Just for Viruses: Cytosolic Sensing of Bacterial Nucleic Acids
20110 citationsauthor #1
NLRX1 protein attenuates inflammatory responses to virus infection by interfering with the RIG-I-MAVS signaling pathway and TRAF6 ubiquitin ligase
20119 citationsauthor #14
The N-Ethyl-N-Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides
2010544 citationsauthor #4
Microreview Induction of type I interferons by bacteriacmi
20100 citationsauthor #1
Induction of type I interferons by bacteria
2010154 citationsauthor #1
Identification of Host Cytosolic Sensors and Bacterial Factors Regulating the Type I Interferon Response to Legionella pneumophila
2009206 citationsauthor #1
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
2009310 citationsauthor #3
Inhibition of sucrose induced fructosyltransferase gene expression in streptococcus mutans
19920 citationsauthor #1

TIMELINE

1992 0 citations

2009 516 citations

2010 698 citations

2011 1,864 citations

2013 1,849 citations

2014 505 citations

2015 181 citations

2017 15 citations

2019 576 citations

2020 617 citations

2021 248 citations

2022 59 citations

2023 200 citations

2024 27 citations

2025 7 citations

2026 0 citations

K. Monroe

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