T. Simeone

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Aliases
T. A. Simeone, Timothy A Simeone, Timothy Simeone, Timothy A. Simeone
Publication record
55 papers · 1,902 citations · H-index 24

PAPERS

Targeted Reduction of Excessive Mitochondrial Superoxide by Mitoquinone Rescues Cognitive Impairment Without Affecting Spontaneous Recurrent Seizures in a Mouse Model of Temporal Lobe Epilepsy.
20260 citationsauthor #8
A Longitudinal Study of the Effects of Ketogenic Diet on Seizures, Cardiorespiration, Sleep Architecture and Mortality in the Kv1.1 Knockout Mouse Model of Sudden Unexpected Death in Epilepsy (SUDEP)
20260 citationsauthor #5
Development and characterization of an autoresuscitation test for preclinical SUDEP models
20252 citationsauthor #6
In Preclinical Epilepsy, GLUT1 and GFAP Dysregulation in Cells Surrounding the Third Ventricle, Including Tanycytes, Is Differentially Restored with Ketogenic Diet Treatment
20250 citationsauthor #11
Allostatic load of immune cells in the spleen and brain of the Kcna1-null mouse model of temporal lobe epilepsy.
20250 citationsauthor #8
Contribution of Seizures and Sympathetic Activation on the Adaptive Immune Response of Kcna1-null Mice, a Model of Spontaneous Recurrent Seizures (Abstract ID: 190411)
20250 citationsauthor #8
The Unconventional Effects of the Ketogenic Diet (KD) in Preclinical Epilepsy
20241 citationsauthor #1
CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression
20241 citationsauthor #7
Dietary and Metabolic Approaches for Treating Autism Spectrum Disorders, Affective Disorders and Cognitive Impairment Comorbid with Epilepsy: A Review of Clinical and Preclinical Evidence
20244 citationsauthor #7
Altered ventilatory responses to hypercapnia-hypoxia challenges in a preclinical SUDEP model involve orexin neurons
20248 citationsauthor #5
Orexin receptors regulate hippocampal sharp wave-ripple complexes in ex vivo slices.
20232 citationsauthor #7
Personalization of SUDEP risk: A survey of transient subclinical comorbid changes.
20238 citationsauthor #12
Ascorbic Acid Reduces Neurotransmission, Synaptic Plasticity, and Spontaneous Hippocampal Rhythms in In Vitro Slices
202210 citationsauthor #8
Functional MRI Correlates of Carbon Dioxide Chemosensing in Persons With Epilepsy
20228 citationsauthor #6
Carbamazepine Reduces Sharp Wave-Ripple Complexes and Exerts Synapse-Specific Inhibition of Neurotransmission in Ex Vivo Hippocampal Slices
20216 citationsauthor #1
Pharmacoresponsiveness of spontaneous recurrent seizures and the comorbid sleep disorder of epileptic Kcna1-null mice.
202111 citationsauthor #9
Ketogenic diet–mediated seizure reduction preserves CA1 cell numbers in epileptic Kcna1‐null mice: An unbiased stereological assessment
202112 citationsauthor #4
Aberrant energy metabolism and redox balance in seizure onset zones of epileptic patients.
20209 citationsauthor #9
Progressive cardiorespiratory dysfunction in Kv1.1 knockout mice may provide temporal biomarkers of pending sudden unexpected death in epilepsy (SUDEP): The contribution of orexin
202029 citationsauthor #6
Changes in lipid profiles of epileptic mouse model
202017 citationsauthor #9
Highlights From the Annual Meeting of the American Epilepsy Society 2018
20195 citationsauthor #14
Respiratory dysfunction progresses with age in Kcna1‐null mice, a model of sudden unexpected death in epilepsy
201851 citationsauthor #12
Ketogenic diet regulates the antioxidant catalase via the transcription factor PPARγ2.
201828 citationsauthor #6
Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?
2018122 citationsauthor #1
Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders.
201812 citationsauthor #2
Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy
201827 citationsauthor #3
Ketone Bodies as Anti-Seizure Agents
20170 citationsauthor #1
Synergistic protection against acute flurothyl‐induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone
201724 citationsauthor #1
Ketone Bodies as Anti-Seizure Agents
201777 citationsauthor #1
Regulation of brain PPARgamma2 contributes to ketogenic diet anti‐seizure efficacy
201782 citationsauthor #1
Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in Kcna1-null Mice.
201672 citationsauthor #2
Ketogenic diet treatment increases longevity in Kcna1‐null mice, a model of sudden unexpected death in epilepsy
201666 citationsauthor #4
Breathe Easy: Modifying Mitochondrial Respiration to Treat Seizures
20160 citationsauthor #2
Ketone bodies mediate antiseizure effects through mitochondrial permeability transition
2015160 citationsauthor #3
Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures.
201467 citationsauthor #4
In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv1.1α knockout mice
201442 citationsauthor #1
Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices.
201368 citationsauthor #1
Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors.
201119 citationsauthor #1
cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABA(A) receptors.
20117 citationsauthor #2
cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABA(A) receptors.
20117 citationsauthor #1
L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue
201122 citationsauthor #6
Antiepileptic drugs: Antiepileptic drug mechanisms
20092 citationsauthor #1
Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.
200895 citationsauthor #4
FULL-LENGTH ORIGINAL RESEARCH GABA A receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
20080 citationsauthor #3
GABAA receptor‐mediated activation of L‐type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
200869 citationsauthor #3
Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesis.
200788 citationsauthor #4
Ketone bodies are protective against oxidative stress in neocortical neurons
2007199 citationsauthor #5
Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors.
200661 citationsauthor #1
dissociated rat hippocampal neurones Single channel properties of hyperpolarization-activated cation currents in acutely
20060 citationsauthor #1
Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.
200611 citationsauthor #1
Seizures reduce the expression of the hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel I via Ca++/calmodulin dependent protein kinase II activation
20054 citationsauthor #4
Single channel properties of hyperpolarization‐activated cation currents in acutely dissociated rat hippocampal neurones
200532 citationsauthor #1
Molecular Biology and Ontogeny of Glutamate Receptors in the Mammalian Central Nervous System
2004104 citationsauthor #1
Modulation by Topiramate of AMPA and Kainate Mediated Calcium Influx in Cultured Cerebral Cortical, Hippocampal and Cerebellar Neurons
200481 citationsauthor #2
Molecular Biology and Ontogeny of γ-Aminobutyric Acid (GABA) Receptors in the Mammalian Central Nervous System
200356 citationsauthor #1
Molecular biology and ontogeny of gamma-aminobutyric acid (GABA) receptors in the mammalian central nervous system.
200326 citationsauthor #1

TIMELINE

2003 82 citations

2004 185 citations

2005 36 citations

2006 72 citations

2007 287 citations

2008 164 citations

2009 2 citations

2011 48 citations

2013 68 citations

2014 109 citations

2015 160 citations

2016 138 citations

2017 183 citations

2018 240 citations

2019 5 citations

2020 55 citations

2021 29 citations

2022 18 citations

2023 10 citations

2024 14 citations

2025 2 citations

2026 0 citations

T. Simeone

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