T. Kawaguchi

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Aliases
T Kawaguchi, T. Kawaguchi, Takeo Kawaguchi
Publication record
77 papers · 1,029 citations · H-index 21

PAPERS

Antitumor activity of 3′, 5′-diesters of 5-fluoro-2′-deoxyuridine against murine leukemia L1210 cells
20043 citationsauthor #5
Clinical Pharmacokinetics of Cytarabine Formulations
2002108 citationsauthor #2
Bromocriptine Reverses P‐Glycoprotein‐mediated Multidrug Resistance in Tumor Cells
200228 citationsauthor #6
Enzymatic Reactivity and Antitumor Activity of 1‐(β‐D‐Arabinofuranosyl)‐2‐thiocytosine Derivatives.
20003 citationsauthor #1
Enzymatic reactivity and anti-tumor activity of 1-(beta-D-arabinofuranosyl)-2-thiocytosine derivatives.
20008 citationsauthor #1
Roles of hydrophobicity, protein binding and the probenecid-sensitive transport system in the cerebrospinal fluid delivery of nucleoside analogues with anti-viral activity.
20007 citationsauthor #1
Relationship between Solubility of Chitosan in Alcoholic Solution and Its Gelation
199940 citationsauthor #5
Cytotoxicity and pharmacokinetics of 1-beta-D-arabinofuranosyl-2-thiocytosine, a 2-sulphur substituted derivative of cytarabine.
19993 citationsauthor #1
Nasal transport of thymidine in rats.
19980 citationsauthor #5
Direct transport of 2',3'-didehydro-3'-deoxythymidine (D4T) and its ester derivatives to the cerebrospinal fluid via the nasal mucous membrane in rats.
199825 citationsauthor #5
Synthetic Nucleosides and Nucleotides. Part 40. Selective Inhibition of Eukaryotic DNA Polymerase α by 9‐(β‐D‐Arabinofuranosyl)‐2‐(p‐n‐butylanilino)adenine 5′‐Triphosphate (BuAaraATP) and Its 2′‐Up Azido Analogue: Synthesis and Enzymatic Evaluations.
19983 citationsauthor #7
Synthetic nucleosides and nucleotides. 40. Selective inhibition of eukaryotic DNA polymerase alpha by 9-(beta-D-arabinofuranosyl)-2-(p-n-butylanilino) adenine 5'-triphosphate (BuAaraATP) and its 2'-up azido analog: synthesis and enzymatic evaluations.
199823 citationsauthor #7
Chiral discrimination of 2'-deoxy-L-cytidine and L-nucleotides by mouse deoxycytidine kinase: low stereospecificities for substrates and effectors.
19978 citationsauthor #6
The effects of several penetration-enhancers on the simultaneous transport and metabolism of ethyl nicotinate in hairless rat skin
19978 citationsauthor #4
Inhibition of 5'-deoxy-5-fluorouridine phosphorolysis by acyclothymidine in tumor cell homogenates.
19970 citationsauthor #5
Chiral influences of feedback inhibition with dCTP on murine deoxycytidine kinase.
19971 citationsauthor #3
Inhibition of 5-fluoro-2'-deoxyuridine(FUdR) induced apototic cell death by c-fos and c-jun antisense oligodeoxynucleotides.
19970 citationsauthor #6
Antileukemic Activities and Mechanism of Action of 2′-Deoxy-4′-methylcytidine and Related Nucleosides
199712 citationsauthor #4
Permeation of Zidovudine and Probenecid from Oily Bases Containing Alcohols Through Rat Skin
19964 citationsauthor #2
Nasal absorption of 2',3'-didehydro-3'-deoxythymidine (D4T) and its esters in rats.
19967 citationsauthor #5
Synthetic nucleosides and nucleotides. 37. Antisense oligodeoxynucleotides bearing 5-(phenylethyl)-2'-deoxyuridylate at the 3'-terminus: exonuclease-resistant molecule with natural phosphodiester backbone.
19962 citationsauthor #1
Steric parameters in PLE catalyzed hydrolysis of N-4-substituted cytarabine ester prodrugs
19965 citationsauthor #1
Modulation of the pharmacokinetics of 5'-deoxy-5-fluorouridine and 5-fluorouracil in rats by oral co-administration of acyclothymidine.
19964 citationsauthor #5
Acyclothymidine alleviates intestinal toxicity of 5'-deoxy-5-fluorouridine without loss of antitumor activity in mice.
19960 citationsauthor #5
Metabolism of testosterone and its ester derivatives in organotypic coculture of human dermal fibroblasts with differentiated epidermis
19965 citationsauthor #7
Intestinal absorption and first-pass elimination of 2', 3'-dideoxynucleosides following oral administration in rats.
199614 citationsauthor #4
Synthesis and antileukemic activity of chymotrypsin-activated derivatives of 3'-amino-2',3'-dideoxycytidine. (Synthetic nucleosides and nucleotides. XXXIII.
19954 citationsauthor #1
Synthesis and investigation of N4-substituted cytarabine derivatives as prodrugs.
199512 citationsauthor #6
Stability, specific binding activity, and plasma concentration in mice of an oligodeoxynucleotide modified at 5'-terminal with poly(ethylene glycol).
199530 citationsauthor #1
Inhibition of 5'-deoxy-5-fluorouridine phosphorolysis by acyclopyrimidinenucleosides in intestinal tissue homogenates.
19953 citationsauthor #4
Future of Prodrugs in Antiviral Therapy
19945 citationsauthor #2
Nasal absorption of zidovudine and its transport to cerebrospinal fluid in rats.
199466 citationsauthor #4
Prodrugs of 2′,3′-Didehydro-3′-deoxythymidine.
19941 citationsauthor #5
Enzymatic stability and plasma concentration of double-stranded oligodeoxynucleotides(ODNs) composed of unmodified antisense ODN and chemicaly modified sense ODNs.
19940 citationsauthor #1
Reduced nephrotoxicity of cisplatin in multiple-phase emulsion.
19940 citationsauthor #2
Novel Stabilizing Method for Antisense Oligodeoxynucleotides
19941 citationsauthor #6
Differential effects of acyclothymidine, a potent pyrimidine nucleoside phosphorylase inhibitor, on the pharmacokinetics of doxifluridine in rabbits via oral administration.
19931 citationsauthor #5
Prodrugs of 2',3'-didehydro-3'-deoxythymidine.
19935 citationsauthor #5
Prodrugs of 2',3'-dideoxyinosine (DDI): improved oral bioavailability via hydrophobic esters.
199216 citationsauthor #1
Control of drug release with a combination of prodrug and polymer matrix: antitumor activity and release profiles of 2',3'-diacyl-5-fluoro-2'-deoxyuridine from poly(3-hydroxybutyrate) microspheres.
199235 citationsauthor #1
Anticancer effects of free polyunsaturated fatty acids in an oily lymphographic agent following intrahepatic arterial administration to a rabbit bearing VX-2 tumor.
199219 citationsauthor #4
Controlled release of 5-fluoro-2'-deoxyuridine by the combination of prodrug and polymer matrix.
19914 citationsauthor #2
Sustained transdermal delivery of zidovudine via controlled release of penetration enhancer
199125 citationsauthor #2
Rectal absorption of Zidovudine
199114 citationsauthor #1
Plasma concentrations of zidovudine in rats via oral administration of its ester prodrugs.
19919 citationsauthor #1
Enhanced Delivery of Zidovudine Through Rat and Human Skin via Ester Prodrugs
199023 citationsauthor #2
Membrane permeation-controlled transdermal delivery system design. Influence of controlling membrane and adhesive on skin permeation of isosorbide dinitrate.
19905 citationsauthor #2
Ester prodrugs of 2′,3′-dideoxy-2′,3′-didehydrothymidine (D4T)
19907 citationsauthor #1
Controlled release of 3',5'-diester prodrugs of 5-fluoro-2'-deoxyuridine from poly-L-lactic acid microspheres.
199025 citationsauthor #2
Enhanced transdermal delivery of zidovudine in rats and human skin.
199027 citationsauthor #3
Ester prodrugs of zidovudine.
199045 citationsauthor #1
Application of new silicone gel to sustained release dosage form of antitumor drug.
19892 citationsauthor #4
Intraarterial infusion of 5‐fluoro‐2‐deoxyuridine‐C8 dissolved in a lymphographic agent in malignant liver tumors. A preliminary report
198929 citationsauthor #5
Percutaneous absorption of azidothymidine in rats
198919 citationsauthor #2
Studies on 2',3'-dideoxy-2',3'-didehydropyrimidine nucleosides. II. N4-benzoyl-2',3'-dideoxy-2',3'-didehydrocytidine as a prodrug of 2',3'-dideoxy-2',3'-didehydrocytidine (DDCN).
19895 citationsauthor #1
Enzymatic and chemical stability of 2',3'-dideoxy-2',3'-didehydropyrimidine nucleosides: potential anti-acquired immunodeficiency syndrome agents.
198925 citationsauthor #1
Hydrolysis of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) in rabbit and human plasma and its release from oily solution.
19891 citationsauthor #3
Specificity of esterases and structure of prodrug esters: reactivity of various acylated acetaminophen compounds and acetylaminobenzoated compounds.
198823 citationsauthor #2
[Release profiles of 5-fluorouracil and its lipophilic derivatives from lipiodol solutions].
19880 citationsauthor #1
Specificity of esterases and structure of prodrug esters: reactivity of various acylated acetaminophen compounds and acetylaminobenzoated compounds.
198823 citationsauthor #3
Nonenzymatic and Enzymatic Hydrolysis of 5-Fluoro-2′-deoxyuridine (FUdR) Esters
19886 citationsauthor #1
Selective accumulation of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) and sustained release of its active metabolites in VX-2 rabbit hepatoma following intraarterial administration of FdUrd-C8 solution in Lipiodol.
19887 citationsauthor #1
and Sustained Release of Its Active Metabolites in VX-2 Rabbit Hepatoma followingIntraarterial Administration of FdUrd-C8 Solution in Lipiodol
19880 citationsauthor #1
Potentiation of the antitumor effect of 5-fluoro-2'-deoxyuridine esters in combination with acyclothymidine esters on L1210 in mice via oral administration.
19880 citationsauthor #1
Inhibition of phosphorolytic degradation of 5-fluoro-2'-deoxyuridine by pyrimidine acyclonucleosides and normal pyrimidine metabolites in rat and beagle tissue homogenates.
19880 citationsauthor #1
Selective anticancer effects of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine, a lipophilic prodrug of 5-fluoro-2'-deoxyuridine, dissolved in an oily lymphographic agent on hepatic cancer of rabbits bearing VX-2 tumor.
198727 citationsauthor #2
In vitro drug release from macromolecule-drug conjugates of 3'-(7-carboxyheptanoyl)-5-fluoro-2'-deoxyuridine with decylenediamine-dextran T70 of poly-L-lysine.
19877 citationsauthor #2
Potentiation by acyclothymidine esters of the antitumor effect of orally administered 5-fluoro-2'-deoxyuridine esters on L1210 in mice.
19860 citationsauthor #1
Specificity of esterases and structure of prodrug esters. II. Hydrolytic regeneration behavior of 5-fluoro-2'-deoxyuridine (FUdR) from 3',5'-diesters of FUdR with rat tissue homogenates and plasma in relation to their antitumor activity.
198528 citationsauthor #1
Specificity of esterases and structures of prodrug esters. III. Activity of rat tissue homogenates, rat plasma and porcine liver esterase for the hydrolysis of 3',5'-bis-dicarboxylic acid hemiesters of 5-fluoro-2'-deoxyuridine.
198512 citationsauthor #1
Activity of esterase in the hydrolysis of 3',5'-diesters of 5-fluoro-2'-deoxyuridine in relation to the structure of the diester prodrugs.
198523 citationsauthor #1
Specificity of Esterases and Effect of Structure of Prodrug Esters of Acylated Acetaminophen on Hydrolytic Reactivity
19840 citationsauthor #3
OF ACYLATED ACETAMINOPHEN ON HYDROLYTIC REACTIVITY
19840 citationsauthor #3
Examination of biodegradability of poly(ethylene carbonate) and poly(propylene carbonate) in the peritoneal cavity in rats.
198369 citationsauthor #1
Plasma levels of tegafur following implantation of polycarbonate pellets containing tegafur or FD-1 into rats.
19839 citationsauthor #1
Release profiles 5-fluorouracil and its derivatives from polycarbonate matrices in vitro.
198211 citationsauthor #1
Studies on Catalytic Actions of Complex Salts (I) : Catalytic Actions of Ammino-copper and Ammino-nickel Complex Salts in Decomposition of Hydrogen Peroxide
19680 citationsauthor #1

TIMELINE

1968 0 citations

1982 11 citations

1983 78 citations

1984 0 citations

1985 63 citations

1986 0 citations

1987 34 citations

1988 36 citations

1989 81 citations

1990 132 citations

1991 52 citations

1992 70 citations

1993 6 citations

1994 73 citations

1995 49 citations

1996 41 citations

1997 29 citations

1998 51 citations

1999 43 citations

2000 18 citations

2002 136 citations

2004 3 citations

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