K. Higashimoto

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Aliases
K Higashimoto, Ken Higashimoto
Publication record
71 papers · 1,762 citations · H-index 23

PAPERS

Whole-exome sequencing reveals causative genetic variants for several overgrowth syndromes in molecularly negative Beckwith-Wiedemann spectrum
20243 citationsauthor #1
Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith–Wiedemann syndrome-like overgrowth
20243 citationsauthor #6
Exploration of genetic causes of biparental placenta mesenchymal dysplasia
20230 citationsauthor #2
Donor cord blood aging accelerates in recipients after transplantation
20233 citationsauthor #12
Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells
20235 citationsauthor #2
Placental Mesenchymal Dysplasia and Beckwith–Wiedemann Syndrome
202215 citationsauthor #4
Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasia
20220 citationsauthor #2
Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasia
20229 citationsauthor #2
Phenotypically concordant but epigenetically discordant monozygotic dichorionic diamniotic twins with Beckwith–Wiedemann syndrome
20216 citationsauthor #6
Clinical manifestations of placental mesenchymal dysplasia in Japan: A multicenter case series
202116 citationsauthor #4
TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients
202110 citationsauthor #4
Hypomethylation of a centromeric block of ICR1 is sufficient to cause Silver-Russell syndrome
20202 citationsauthor #1
TYK2 Promoter Variant, a Putative Virus-Induced Diabetes Susceptibility Gene, Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients
20200 citationsauthor #4
Habitual Light-intensity Physical Activity and ASC Methylation in a Middle-aged Population
201917 citationsauthor #12
Beckwith-Wiedemann syndrome with asymmetric mosaic of paternal disomy causing hemihyperplasia.
20195 citationsauthor #3
The extent of DNA methylation anticipation due to a genetic defect in ICR1 in Beckwith-Wiedemann syndrome
201913 citationsauthor #2
DNA methylation analysis of multiple imprinted DMRs in Sotos syndrome reveals IGF2‐DMR0 as a DNA methylation‐dependent, P0 promoter‐specific enhancer
201913 citationsauthor #2
Growing oocyte-specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR
20180 citationsauthor #5
Growing oocyte-specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR
201818 citationsauthor #5
Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer
201821 citationsauthor #2
Differences in the Genotype Frequency of the RNF213 Variant in Patients with Familial Moyamoya Disease in Kyushu, Japan
20177 citationsauthor #2
Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome
201786 citationsauthor #2
Genomic Imprinting Syndromes and Cancer
20171 citationsauthor #1
CTCF deletion syndrome: clinical features and epigenetic delineation
201725 citationsauthor #5
Hepatoblastoma in an extremely low birth-weight infant with Beckwith-Wiedemann syndrome.
20174 citationsauthor #5
Long term survival of a patient with Perlman syndrome due to novel compound heterozygous missense mutations in RNB domain of DIS3L2
20178 citationsauthor #2
Identification of consensus motifs associated with mitotic recombination and clinical characteristics in patients with paternal uniparental isodisomy of chromosome 11.
201619 citationsauthor #2
The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants.
201611 citationsauthor #4
Autosomal recessive cystinuria caused by genome‐wide paternal uniparental isodisomy in a patient with Beckwith–Wiedemann syndrome
201519 citationsauthor #2
Molecular genetic investigation of placental mesenchymal dysplasia
20150 citationsauthor #2
Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole
201517 citationsauthor #12
Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions to aberrant methylation in Beckwith–Wiedemann syndrome with epimutations
201435 citationsauthor #2
Fibroadenoma in Beckwith–Wiedemann syndrome with paternal uniparental disomy of chromosome 11p15.5
20149 citationsauthor #4
A novel de novo point mutation of the OCT‐binding site in the IGF2/H19‐imprinting control region in a Beckwith–Wiedemann syndrome patient
201429 citationsauthor #1
The clinical presentation of placental mesenchymal dysplasia; Japanese publication based study
20130 citationsauthor #5
Molecular genetic analyses of 11p15 region in placentae with mesenchymal dysplasia
20130 citationsauthor #2
Novel mutations of CDKN1C in Japanese patients with Beckwith-Wiedemann syndrome
20134 citationsauthor #2
Congenital hyperinsulinism in an infant with paternal uniparental disomy on chromosome 11p15: few clinical features suggestive of Beckwith-Wiedemann syndrome.
201316 citationsauthor #3
Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma
20130 citationsauthor #5
Ash1l Methylates Lys36 of Histone H3 Independently of Transcriptional Elongation to Counteract Polycomb Silencing
201384 citationsauthor #2
Novel mutations of CDKN1C in Japanese patients with Beckwith-Wiedemann syndrome
20130 citationsauthor #2
Homozygous deletion of DIS3L2 exon 9 due to non-allelic homologous recombination between LINE-1s in a Japanese patient with Perlman syndrome
201326 citationsauthor #1
Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma
201332 citationsauthor #5
Epigenetic and genetic alterations of the imprinting disorder Beckwith–Wiedemann syndrome and related disorders
2013143 citationsauthor #2
Aberrant methylation of H19‐DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith–Wiedemann syndrome
20128 citationsauthor #1
Beckwith–Wiedemann syndrome with placental chorangioma due to H19‐differentially methylated region hypermethylation: A case report
201114 citationsauthor #4
Acute megakaryocytic leukemia (AMKL,FAB;M7) with Beckwith–wiedemann syndrome
20101 citationsauthor #4
Antisense transcription occurs at the promoter of a mouse imprinted gene, commd1, on the repressed paternal allele.
20096 citationsauthor #3
MeCP2 knockdown reveals DNA methylation-independent gene repression of target genes in living cells and a bias in the cellular location of target gene products.
200823 citationsauthor #6
Retinoic acid receptor beta2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells.
200712 citationsauthor #6
Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1
2007107 citationsauthor #1
Japanese and North American/European patients with Beckwith–Wiedemann syndrome have different frequencies of some epigenetic and genetic alterations
200737 citationsauthor #3
Retinoic acid receptor β2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells
200730 citationsauthor #6
Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours
200664 citationsauthor #4
Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers
2006110 citationsauthor #5
Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice.
200626 citationsauthor #7
Imprinting disruption of the CDKN1C/KCNQ1OT1 domain: the molecular mechanisms causing Beckwith-Wiedemann syndrome and cancer
200673 citationsauthor #1
The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.
200562 citationsauthor #3
Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region.
200426 citationsauthor #3
Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer
200455 citationsauthor #4
Erratum to “characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse”: [Genomics 80 (2002) 575–584]☆☆☆
20030 citationsauthor #1
Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with Beckwith-Wiedemann syndrome.
200343 citationsauthor #1
Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer
2003164 citationsauthor #5
Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse.
200331 citationsauthor #1
Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region.
200270 citationsauthor #3
Imprinting cluster and domain regulation in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5
20020 citationsauthor #4
A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors.
200032 citationsauthor #3
C11orf21, a novel gene within the Beckwith-Wiedemann syndrome region in human chromosome 11p15.5.
20005 citationsauthor #2
Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human.
200017 citationsauthor #9
An NsiI RFLP in the human long QT intronic transcript 1 (LIT1)
20003 citationsauthor #1
DNA Methylation Analysis Using Bisulfite Pyrosequencing.
year unknown12 citationsauthor #1

TIMELINE

2000 57 citations

2002 70 citations

2003 238 citations

2004 81 citations

2005 62 citations

2006 273 citations

2007 186 citations

2008 23 citations

2009 6 citations

2010 1 citations

2011 14 citations

2012 8 citations

2013 305 citations

2014 73 citations

2015 36 citations

2016 30 citations

2017 131 citations

2018 39 citations

2019 48 citations

2020 2 citations

2021 32 citations

2022 24 citations

2023 8 citations

2024 6 citations

Unknown 12 citations

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