biomarkers as signposts

The proposed role of biomarkers as mechanistic indicators used to guide risk assessment rather than as standalone decision thresholds.

• Types

  interpretive frameworks

• Aliases

  signposts

• Contributors
  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review

• Screening and Testing for Endocrine Disruption in Fish—Biomarkers As “Signposts,” Not “Traffic Lights,” in Risk Assessment

  324 citations

• Biomarkers are best used as mechanistic signposts rather than traffic lights in the environmental risk assessment of endocrine-disrupting chemicals.
• Exposure biomarkers such as vitellogenin induction in male fish are useful for tracking substances of concern and for linking field and laboratory data that inform fish chronic tests.
• A historical control database is needed to help distinguish statistically detectable responses from biologically significant ones.

• No direct concept-to-concept edges are published yet.

• environmental risk assessment

  assessment contexts1 shared papers
• endocrine-disrupting chemicals

  chemical classes1 shared papers
• vitellogenin induction

  biomarkers1 shared papers
• fish chronic tests

  toxicity tests1 shared papers
• biomarker noec and ec10

  effect metrics1 shared papers
• predicted no effect concentrations

  regulatory endpoints1 shared papers
• interlaboratory reproducibility

  quality properties1 shared papers
• historical control database

  reference datasets1 shared papers