THE MECHANISM OF THE SPECIFICITY OF TRYPSIN CATALYSIS. 3. ACTIVATION OF THE CATALYTIC SITE OF TRYPSIN BY ALKYLAMMONIUM IONS IN THE HYDROLYSIS OF ACETYLGLYCINE ETHYL ESTER.

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• Publication year

  1964

• Venue

  Journal of Biological Chemistry

• Publication date

  1964-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 14193830
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• THE MECHANISM OF THE SPECIFICITY OF TRYPSIN CATALYSIS. II. COMPARISON OF TRYPSIN AND ALPHA-CHYMOTRYPSIN IN THE NONSPECIFIC CATALYSES OF TEH HYDROLYSIS OF ACETYLGLYCINE ETHYL ESTER.

  1964cited by this paper
• THE MECHANISM OF THE SPECIFICITY OF TRYPSIN CATALYSIS. I. INHIBITION BY ALKYL AMMONIUM IONS.

  1964cited by this paper
• SUBSTRATE ACTIVATION OF TRYPSIN.

  1963cited by this paper
• Induced activation of the catalytic site of trypsin.

  1963cited by this paper
• Specificity of alpha-chymotrypsin. I. Promotion of the solvolysis of acetyl alpha-chymotrypsin by indole.

  1961cited by this paper
• Nonspecific catalyses by alpha-chymotrypsin and trypsin.

  1960cited by this paper
• Hydrolysis and transpeptidation of lysine peptides by trypsin.

  1956cited by this paper
• Identification of a peptide released during autocatalytic activation of trypsinogen.

  1955cited by this paper
• Molecular-kinetic properties of crystalline diisopropyl phosphoryl trypsin.

  1954cited by this paper
• The specific esterase activity of trypsin.

  1948cited by this paper

• Kinetic Studies of the Effect of pH on the Trypsin-Catalyzed Hydrolysis of N-α-benzyloxycarbonyl-l-lysine-p-nitroanilide: Mechanism of Trypsin Catalysis

  2020cites this paper
• Kinetics of Enzyme-Modifier Interactions

  2015cites this paper
• The Basic Mechanisms of Inhibition and Nonessential Activation

  2015cites this paper
• Inhibition of trypsin by t‐Butyloxycarbonyl‐α‐aza‐(4‐aminophenyl)alanine phenyl ester

  2007cites this paper
• Catalytic and ligand binding properties of bovine trypsinogen and its complex with the effector dipeptide Ile-Val

  2004cites this paper
• Serine protease mechanism and specificity.

  2002cites this paper
• Role of phosphorylation in determining the backbone dynamics of the serine/threonine-proline motif and Pin1 substrate recognition.

  1998cites this paper
• Probing trypsin specificity with basic 3-substituted glutarate diesters and related monoester substrate analogs: Evidence for allosteric activation of trypsin catalysis

  1992cites this paper
• Inhibition of trypsin by t-butyloxycarbonyl-alpha-aza-(4-aminophenyl)alanine phenyl ester.

  1991cites this paper
• Thermodynamic modeling of internal equilibria involved in the activation of trypsinogen.

  1990cites this paper
• Bovine trypsinogen activation. A thermodynamic study.

  1990cites this paper
• Pressure effects on substrate activation phenomena in the alpha-chymotrypsin-catalyzed hydrolysis of p-nitrophenyl acetate.

  1988cites this paper
• Inverse substrates for trypsin and trypsin-like enzymes

  1987cites this paper
• Serine carboxypeptidases. A review

  1986cites this paper
• Kinetics of hydrolysis of amide and anilide substrates of p-guanidino-L-phenylalanine by bovine and porcine trypsins.

  1985cites this paper
• Oxygen and sulfur esters of "inverse substrates": different responses of amidinophenol and amidinothiophenol in the activation of the rate of tryptic hydrolysis of the inverse esters.

  1985cites this paper
• Isolation and characterization of the polyphenoloxidase from senescent leaves of black poplar

  1984cites this paper
• Chemically modified carboxypeptidase Y with increased amidase activity

  1984cites this paper
• Influence of guanidine derivatives on the specificity of malt carboxypeptidase

  1983cites this paper
• Amino acid methyl esters as amine components in CPD-Y catalyzed peptide synthesis: Control of side reactions

  1983cites this paper
• Cryoenzymology of trypsin. A detailed kinetic study of the trypsin-catalysed hydrolysis of N-alpha-benzyloxycarbonyl-L-lysine p-nitrophenyl ester at low temperatures.

  1983cites this paper
• Comparative studies on the structure of active sites. Behavior of "inverse substrates" toward trypsin and related enzymes.

  1982cites this paper
• Catalytic properties of human urinary kallikrein.

  1982cites this paper
• Catalytic properties of human urinary kallikrein 1

  1982cites this paper
• Essential roles of alkylammonium and alkylguanidinium ions in trypsin-catalyzed hydrolysis of acetylglycine esters: enhancement of catalytic efficiency analyzed by the use of "inverse substrates".

  1982cites this paper
• Kinetic evidence for a two-state, hybrid model for the trypsin activation by modifiers.

  1981cites this paper
• The mechanism of trypsin catalysis at low pH. Proposal for a structural model.

  1981cites this paper
• Specific spin-labeling at trypsin active site. Application of 'inverse substrate' to the structural analysis of the active site.

  1980cites this paper
• Induced activation in the deacylation step of tryptic hydrolysis. An application of "inverse substrates" to mechanistic studies of the enzyme.

  1980cites this paper
• A novel chiral microenvironmental probe at the active site of trypsin. Extrinsic cotton effects of acyl-trypsin possessing an enantiomeric pair of chromophores.

  1980cites this paper
• Determinant of efficiency of a monomeric enzyme: Acceleration by site-specific molecules for trypsin

  1979cites this paper
• [Design of "inverse substrates": a new approach for the chemical studies of hydrolytic enzymes (author's transl)].

  1979cites this paper
• Properties of the single sulfhydryl group of carboxypeptidase Y. Effects of alkyl and aromatic mercurials on activities toward various synthetic substrates.

  1979cites this paper
• Effect of methylamine on trypsin catalysis.

  1978cites this paper
• Kinetics of the action of thermolysin on peptide substrates.

  1978cites this paper
• Binding of alkylamines to trypsin as measured by difference spectroscopy.

  1976cites this paper
• Disulfide bond-modified trypsinogen. Role of disulfide 179-203 on the specificity characteristics of bovine trypsin toward synthetic substrates.

  1976cites this paper
• Purification and properties of D-glyceraldehyde-3-phosphate dehydrogenase from an extreme thermophile, Thermus thermophilus strain HB 8.

  1976cites this paper
• Specificity of trypsin and alpha-chymotrypsin towards neutral substrates.

  1976cites this paper
• Alkylamine-dependent oxidation and oxygenation of alpha-monoamino acids by lysine monooxygenase.

  1975cites this paper
• Acetylcholinesterase.

  1975cites this paper
• Fixed Enzymes, Application of the Study of Protein Structure and Function

  1975cites this paper
• Alkylamine-dependent oxidation and oxygenation of α-monoamino acids by lysine monooxygenase

  1975cites this paper
• Effect of cytidine‐5′‐monophosphate on peptidyl transferase activity

  1975cites this paper
• The pH jump study of enzyme proteins. I. Liquefying alpha-amylase from Bacillus subtilis.

  1975cites this paper
• Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding.

  1974cites this paper
• Kinetics of the hydrolysis of N-benzoyl-L-serine methyl ester catalysed by bromelain and by papain. Analysis of modifier mechanisms by lattice nomography, computational methods of parameter evaluation for substrate-activated catalyses and consequences of postulated non-productive binding in bromelai

  1974cites this paper
• Evidence for nonproductive binding subsites within the active site of papain.

  1974cites this paper
• Comparative kinetic properties of alpha, beta and psi forms of trypsin.

  1974cites this paper
• Evidence for the induction of a conformational change of trypsin by a specific substrate at pH 8.0

  1973cites this paper
• Conformational adaptability in enzymes.

  1973cites this paper
• Cholate enhancement of interaction between thrombin and tosyl lysine chloromethyl ketone.

  1973cites this paper
• [B6 enzymes. II. Affinity labeling of aspartate aminotransferase and the structure of its active site].

  1973cites this paper
• Comparison of trypsin activated by alkylammonium ions and alpha-chymotrypsin.

  1973cites this paper
• The effect of bile salts on the esterase activities of plasmin and some other enzymes.

  1973cites this paper
• Evidence for the presence of a distinct subsite for binding the distal carboxyl group of dicarboxylate substrates and its role in the catalytic activity of aspartate aminotransferase.

  1972cites this paper
• Studies on puff adder (Bitis arietans) venom. II. Specificity of protease A.

  1972cites this paper
• Alkylamine-dependent amino-acid oxidation by lysine monooxygenase--fragmented substrate of oxygenase.

  1972cites this paper
• Amines as modifiers of the tryptic hydrolysis of neutral substrates.

  1971cites this paper
• Specificity and mechanism of clostripain catalysis.

  1971cites this paper
• Enhancement of tryptic esterase activity.

  1971cites this paper
• The similarity of trypsin activated by alkylammonium ions, to -chymotrypsin.

  1971cites this paper
• On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase.

  1970cites this paper
• The specificity and mechanism of pepsin action.

  1970cites this paper
• Effect of alkylguanidines on the inactivation of trypsin by alkylation and phosphorylation.

  1969cites this paper
• Pseudotrypsin. A modified bovine trypsin produced by limited autodigestion.

  1969cites this paper
• Hydrophobic interactions of some alcohols with acyl trypsins.

  1969cites this paper
• The catalytic and regulatory properties of enzymes.

  1968cites this paper
• The interaction of trypsin with neutral substrates and modifiers.

  1968cites this paper
• Effect of alkylguanidines and alkylamines on trypsin catalysis.

  1968cites this paper
• [Effect of pH on the binding of synthetic competitive inhibitors by trypsin].

  1967cites this paper
• Effet du pH sur la fixation d'inhibiteurs compétitifs synthétiques par la trypsine

  1967cites this paper
• On the interaction of trypsin with neutral substrates and inhibitors.

  1967cites this paper
• Alanine aminotransferase. II. The basis for substrate specificity.

  1967cites this paper
• Activation of chymotrypsin catalyted hydrolyses by 9-aminoacridine.

  1966cites this paper
• Stereospecific activation of chymotrypsin catalyzed hydrolyses.

  1966cites this paper
• Inactivation of chymotrypsin by diphenyldiazomethane.

  1966cites this paper
• Protein Structure in Relation to Cell Dynamics and Differentiation

  1966cites this paper
• The pancreas.

  1966cites this paper
• THE REACTIVITY OF NUCLEOPHILIC REAGENTS WITH FUROYL-CHYMOTRYPSIN.

  1965cites this paper
• THE CHEMISTRY AND STRUCTURE OF PEPTIDES AND PROTEINS.

  1965cites this paper
• INHIBITION OF YEAST ALCOHOL DEHYDROGENASE BY ALKYLAMMONIUM CHLORIDES.

  1965cites this paper
• MECHANISM OF ACTION OF PROTEOLYTIC ENZYMES.

  1965cites this paper