Diacylglycerol kinase-α phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Oncogene

• Publication date

  2008-02-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1210717PMID 17700527
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
• Diacylglycerol Kinase α Regulates the Secretion of Lethal Exosomes Bearing Fas Ligand during Activation-induced Cell Death of T Lymphocytes*

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• SH 2 Domains Recognize Specific Phosphopeptide Sequences

  2004cited by this paper
• Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro.

  2004influential reference
• Activation of diacylglycerol kinase α is required for VEGF-induced angiogenic signaling in vitro

  2004influential reference
• Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.

  2004cited by this paper
• RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane.

  2004cited by this paper
• Phosphorylation of Raf-1 by p21-activated Kinase 1 and Src Regulates Raf-1 Autoinhibition*

  2003cited by this paper
• T Cell Activation In Vivo Targets Diacylglycerol Kinase α to the Membrane: A Novel Mechanism for Ras Attenuation1

  2003cited by this paper
• Protein Kinase Cα Phosphorylates and Negatively Regulates Diacylglycerol Kinase ζ*

  2003cited by this paper
• Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.

  2003cited by this paper
• Regulation of Diacylglycerol Kinase α by Phosphoinositide 3-Kinase Lipid Products*

  2003influential reference
• Modulation of Membrane Curvature by Phosphatidic Acid and Lysophosphatidic Acid

  2003cited by this paper
• Regulation of diacylglycerol kinase alpha by phosphoinositide 3-kinase lipid products.

  2003influential reference
• Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta.

  2003cited by this paper
• Enhanced T cell responses due to diacylglycerol kinase ζ deficiency

  2003cited by this paper
• Diacylglycerol Kinase δ Suppresses ER-to-Golgi Traffic via Its SAM and PH Domains

  2002cited by this paper
• Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains.

  2002cited by this paper
• Expression of a catalytically inactive form of diacylglycerol kinase α induces sustained signaling through RasGRP

  2002cited by this paper
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  2001cited by this paper
• Processive Phosphorylation of p130Cas by Src Depends on SH3-Polyproline Interactions*

  2001cited by this paper
• A peptide model system for processive phosphorylation by Src family kinases.

  2000cited by this paper
• Subtype-specific Translocation of Diacylglycerol Kinase α and γ and Its Correlation with Protein Kinase C*

  2000cited by this paper
• A peptide model system for processive phosphorylation by Src family kinases.

  2000cited by this paper
• Properties and functions of diacylglycerol kinases.

  2000cited by this paper
• Src‐mediated activation of α‐diacylglycerol kinase is required for hepatocyte growth factor‐induced cell motility

  2000influential reference
• Serine and tyrosine phosphorylations cooperate in Raf‐1, but not B‐Raf activation

  1999cited by this paper
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  1999cited by this paper
• Mammalian Diacylglycerol Kinases, a Family of Lipid Kinases with Signaling Functions*

  1999cited by this paper
• Taxonomy and function of C1 protein kinase C homology domains

  1997cited by this paper
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  1997cited by this paper
• Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced -Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation (*)

  1996cited by this paper
• Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src and Syk as assessed by phage display.

  1996cited by this paper
• Recognition and specificity in protein tyrosine kinase-mediated signalling.

  1995cited by this paper
• A role for phosphatidylinositol transfer protein in secretory vesicle formation

  1995cited by this paper
• Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions

  1995cited by this paper
• SH2 domains recognize specific phosphopeptide sequences.

  1993cited by this paper
• Protein Kinase C

  1993cited by this paper
• Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene

  1993influential reference
• T-cell activation.

  1992cited by this paper
• Association of p60c-src with endosomal membranes in mammalian fibroblasts

  1992cited by this paper
• The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding.

  1991cited by this paper
• The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.

  1991cited by this paper
• Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER

  1989cited by this paper
• Activation of (cid:1) -diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase

  year unknowninfluential reference

• Diacylglycerol kinases: Molecular mechanism of cellular and physiological functions.

  2026cites this paper
• Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

  2025cites this paper
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  2025cites this paper
• The role of N-terminal phosphorylation of DGK-θ

  2024cites this paper
• Exosomal miR-21 determines lung-to-brain metastasis specificity through the DGKB/ERK axis within the tumor microenvironment.

  2023cites this paper
• Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction

  2023cites this paper
• Role of Diacylglycerol Kinases in Acute Myeloid Leukemia

  2023cites this paper
• Diacylglycerol kinases: A look into the future of immunotherapy.

  2023cites this paper
• DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell–mediated antitumor immunity

  2023cites this paper
• Phosphorylation of DGK.

  2022cites this paper
• Tumor-associated macrophage (TAM)-derived CCL22 induces FAK addiction in esophageal squamous cell carcinoma (ESCC)

  2022cites this paper
• Regulation of membrane phospholipid biosynthesis in mammalian cells.

  2022cites this paper
• Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity

  2022cites this paper
• Delivering Glioblastoma a Kick—DGKα Inhibition as a Promising Therapeutic Strategy for GBM

  2022cites this paper
• Diacylglycerol Kinase alpha in X Linked Lymphoproliferative Disease Type 1

  2021cites this paper
• Elusive structure of mammalian DGKs.

  2021cites this paper
• Beyond Lipid Signaling: Pleiotropic Effects of Diacylglycerol Kinases in Cellular Signaling

  2020cites this paper
• Lipid composition of the cancer cell membrane

  2020cites this paper
• The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase α

  2020cites this paper
• Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors

  2019cites this paper
• Diacylglycerol kinases: Relationship to other lipid kinases.

  2019cites this paper
• Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.

  2019cites this paper
• The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling

  2018cites this paper
• Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening

  2018cites this paper
• Development of novel avenues to overcome challenges facing CAR T cells.

  2017cites this paper
• Diacylglycerol kinases in cancer.

  2017cites this paper
• Phosphorylation of Dgk1 Diacylglycerol Kinase by Casein Kinase II Regulates Phosphatidic Acid Production in Saccharomyces cerevisiae*

  2016cites this paper
• Diacylglycerol Kinases: Shaping Diacylglycerol and Phosphatidic Acid Gradients to Control Cell Polarity

  2016cites this paper
• Regulation of the yeast DGK1-encoded diacylglycerol kinase

  2016cites this paper
• Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer

  2015cites this paper
• Role of DGKα and DGKζ in the control of lipid metabolism in breast cancer: implications for therapeutic intervention

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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2014cites this paper
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  2013cites this paper
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  2012cites this paper
• Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration

  2012influential citation
• Regulation of diacylglycerol kinase by phosphorylation.

  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
• SAP-Mediated Inhibition of Diacylglycerol Kinase α Regulates TCR-Induced Diacylglycerol Signaling

  2011influential citation
• Regulation and functions of diacylglycerol kinases.

  2011cites this paper
• Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals

  2010cites this paper
• Diacylglycerol kinase α mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

  2010cites this paper
• Chapter 145 – Diacylglycerol Kinases

  2010cites this paper
• Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms.

  2009cites this paper
• Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression.

  2009cites this paper
• Cell and molecular biology of the novel protein tyrosine-phosphatase-interacting protein 51.

  2009cites this paper
• Lck-Dependent Tyrosine Phosphorylation of Diacylglycerol Kinase α Regulates Its Membrane Association in T Cells1

  2008influential citation
• Membrane Association in T Cells Regulates Its α Diacylglycerol Kinase Lck-Dependent Tyrosine Phosphorylation of

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• A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance

  2008cites this paper
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  2008cites this paper
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