Reduced Expression of Hexokinase II in Insulin-Resistant Diabetes

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Diabetes

• Publication date

  1995-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/diab.44.1.43PMID 7813813
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1992cited by this paper
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• Differential regulation of glucose transporter activity and expression in red and white skeletal muscle.

  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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• Regulation of Rat Hexokinase Isoenzymes: I. Assay and Effect of Age, Fasting and Refeeding

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