Interleukin-13/-4-Induced Oxidative Stress Contributes to Death of Hippocampal Neurons in Aβ1-42-Treated Hippocampus In Vivo

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2012-04-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/ars.2011.4175PMID 22248368
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytokine inhibition in severe asthma: current knowledge and future directions

  2011cited by this paper
• Maintenance of anti-inflammatory cytokines and reduction of glial activation in the ischemic hippocampal CA1 region preconditioned with lipopolysaccharide.

  2010cited by this paper
• Endogenous expression of interleukin‐4 regulates macrophage activation and confines cavity formation after traumatic spinal cord injury

  2010cited by this paper
• Human neural stem cells genetically modified to overexpress brain‐derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model

  2010cited by this paper
• IL-13 downregulates PPAR-γ/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death

  2010cited by this paper
• Paroxetine Prevents Loss of Nigrostriatal Dopaminergic Neurons by Inhibiting Brain Inflammation and Oxidative Stress in an Experimental Model of Parkinson’s Disease

  2010cited by this paper
• Neutralisation of Interleukin-13 in Mice Prevents Airway Pathology Caused by Chronic Exposure to House Dust Mite

  2010cited by this paper
• Prothrombin kringle-2-induced oxidative stress contributes to the death of cortical neurons in vivo and in vitro: role of microglial NADPH oxidase.

  2009cited by this paper
• IL-13-Induced Oxidative Stress via Microglial NADPH Oxidase Contributes to Death of Hippocampal Neurons In Vivo1

  2009influential reference
• Conformations and biological activities of amyloid beta peptide 25-35.

  2009cited by this paper
• Regulatory role of cytosolic phospholipase A2α in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Aβ1–42 in microglia

  2009cited by this paper
• Functional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines.

  2009cited by this paper
• Interleukin-4-induced oxidative stress via microglial NADPH oxidase contributes to the death of hippocampal neurons in vivo.

  2008influential reference
• Amyloid Precursor Protein Trafficking, Processing, and Function*

  2008cited by this paper
• Thrombin‐induced oxidative stress contributes to the death of hippocampal neurons: Role of neuronal NADPH oxidase

  2008cited by this paper
• Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity

  2008influential reference
• Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar β amyloid peptide (1-42)-stimulated microglia

  2008cited by this paper
• IL-13-Mediated Gender Difference in Susceptibility to Autoimmune Encephalomyelitis1

  2008cited by this paper
• NADPH oxidase as a therapeutic target in Alzheimer's disease

  2008cited by this paper
• Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein.

  2007cited by this paper
• IL‐4 attenuates the neuroinflammation induced by amyloid‐β in vivo and in vitro

  2007cited by this paper
• Connecting TNF-α Signaling Pathways to iNOS Expression in a Mouse Model of Alzheimer's Disease: Relevance for the Behavioral and Synaptic Deficits Induced by Amyloid β Protein

  2007cited by this paper
• Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies.

  2007cited by this paper
• Pro-atherogenic effect of interleukin-4 in endothelial cells: modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression.

  2006cited by this paper
• The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease

  2006cited by this paper
• Immunology and immunotherapy of Alzheimer's disease

  2006cited by this paper
• Therapeutic Dosing with Anti-Interleukin-13 Monoclonal Antibody Inhibits Asthma Progression in Mice

  2005cited by this paper
• Neuroprotective role of microglia expressing interleukin‐4

  2005influential reference
• Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective

  2005cited by this paper
• Thrombin-Induced Oxidative Stress Contributes to the Death of Hippocampal Neurons In Vivo: Role of Microglial NADPH Oxidase

  2005influential reference
• Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective.

  2005cited by this paper
• Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium

  2005cited by this paper
• Microglia expressing interleukin‐13 undergo cell death and contribute to neuronal survival in vivo

  2004influential reference
• The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.

  2004cited by this paper
• Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling.

  2004cited by this paper
• Minocycline inhibits neuronal death and glial activation induced by β‐amyloid peptide in rat hippocampus

  2004influential reference
• APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.

  2004cited by this paper
• Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse.

  2002cited by this paper
• The Nitration Product 5-Nitro-γ-tocopherol Is Increased in the Alzheimer Brain

  2002cited by this paper
• The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain.

  2002cited by this paper
• N-acetylcysteine inhibits in vivo nitric oxide production by inducible nitric oxide synthase.

  2001cited by this paper
• Transgenic mouse models of Alzheimer's disease.

  2001cited by this paper
• Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing–remitting autoimmune encephalomyelitis in Biozzi AB/H mice

  2001cited by this paper
• Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid.

  2001influential reference
• IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

  2001cited by this paper
• Activation of NADPH oxidase in Alzheimer's disease brains.

  2000cited by this paper
• Expression and Contribution of Endogenous IL-13 in an Experimental Model of Sepsis1

  2000cited by this paper
• Inflammation and Alzheimer's disease.

  2000cited by this paper
• Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

  1998cited by this paper
• Effect of IL‐4 and IL‐13 on IFN‐γ‐induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2

  1997cited by this paper
• Decreases in protease nexins in Alzheimer's disease brain

  1995cited by this paper
• Decreases in protease nexins in Alzheimer's disease brain.

  1995cited by this paper
• Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease.

  1994cited by this paper
• Bacterial expression, purification of full length and carboxyl terminal fragment of Alzheimer amyloid precursor protein and their proteolytic processing by thrombin.

  1994cited by this paper
• Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats.

  1994cited by this paper
• Attenuation of allergic airway inflammation in IL‐4 deficient mice

  1994cited by this paper
• Neuroprotective role of IL-4 against activated microglia.

  1993cited by this paper
• Proteolytic processing of amyloid beta protein precursor (APP) by thrombin.

  1992cited by this paper
• Proteolytic processing of amyloid β protein precursor (APP) by thrombin

  1992cited by this paper
• Thrombin accumulation in brains of patients with Alzheimer's disease.

  1992cited by this paper

• Brain interleukins and Alzheimer’s disease

  2025cites this paper
• Oxidative stress and antioxidant defense system in atherosclerosis and diabetes mellitus type 2

  2025cites this paper
• Comparative cytokine signatures and cognitive deficits in early-onset schizophrenia and adolescent major depression: Toward refined diagnostic classification frameworks.

  2025cites this paper
• Neuroprotective effect of L-DOPA-induced interleukin-13 on striatonigral degeneration in cerebral ischemia

  2024cites this paper
• The inflammatory injury in the striatal microglia-dopaminergic-neuron crosstalk involved in Tourette syndrome development

  2023cites this paper
• New insights toward molecular and nanotechnological approaches to antidiabetic agents for Alzheimer’s disease

  2023cites this paper
• Effect of amyloid-β on the redox system activity in SH-SY5Y cells preincubated with lipopolysaccharide or co-cultured with microglia cells.

  2022cites this paper
• Interleukin-4 Aggravates LPS-Induced Striatal Neurodegeneration In Vivo via Oxidative Stress and Polarization of Microglia/Macrophages

  2022influential citation
• Interleukin 13 on Microglia is Neurotoxic in Lipopolysaccharide-injected Striatum in vivo

  2022cites this paper
• The role of meningeal populations of type II innate lymphoid cells in modulating neuroinflammation in neurodegenerative diseases

  2021cites this paper
• Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection

  2021cites this paper
• Interleukin-13 Propagates Prothrombin Kringle-2-Induced Neurotoxicity in Hippocampi In Vivo via Oxidative Stress

  2021influential citation
• Altered hippocampal function and cytokine levels in a rat model of Gulf War illness.

  2021cites this paper
• Th2 cytokines-DUOX2-ROS-HMGB1 translocation axis is important in the pathogenesis of allergic rhinitis.

  2021cites this paper
• Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson’s disease patients

  2021cites this paper
• INFLUENCE OF THICK EXTRACT FROM MAITAKE MUSHROOMS ON SIGNS OF INFLAMMATORY PROCESS IN EXPERIMENTAL TOXIC HEPATITIS

  2021cites this paper
• Interleukin-13 Affects the Recovery Processes in a Mouse Model of Hemorrhagic Stroke with Bilateral Tibial Fracture

  2021cites this paper
• Higher Interleukin 13 differentiates patients with a positive history of suicide attempts in major depressive disorder

  2021cites this paper
• Murine induced pluripotent stem cell‐derived neuroimmune cell culture models emphasize opposite immune‐effector functions of interleukin 13‐primed microglia and macrophages in terms of neuroimmune toxicity

  2020cites this paper
• Neuroprotective modulation of microglia effector functions following priming with interleukin 4 and 13: current limitations in understanding their mode-of-action.

  2020cites this paper
• Central nervous system immune response in postinfectious hydrocephalus

  2020cites this paper
• Progress of RAGE Molecular Imaging in Alzheimer’s Disease

  2020cites this paper
• Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE)

  2020cites this paper
• Interleukin-4-Mediated Oxidative Stress Is Harmful to Hippocampal Neurons of Prothrombin Kringle-2-Lesioned Rat In Vivo

  2020cites this paper
• Pterostilbene alleviates Aβ1-42 -induced cognitive dysfunction via inhibition of oxidative stress by activating Nrf2 signaling pathway.

  2020cites this paper
• Neuroinflammation in Alzheimer's Disease: Microglia, Molecular Participants and Therapeutic Choices.

  2019cites this paper
• The Effects of Genotype × Phenotype Interactions on Silver Nanoparticle Toxicity in Organotypic Cultures of Murine Tracheal Epithelial Cells

  2019cites this paper
• Interleukin-4 and Interleukin-13 Exacerbate Neurotoxicity of Prothrombin Kringle-2 in Cortex In Vivo via Oxidative Stress

  2019influential citation
• Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress

  2018cites this paper
• Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo

  2018cites this paper
• Microglia antioxidant systems and redox signalling

  2017cites this paper
• DEVELOPMENT OF NITROOXIDATIVE STRESS AND INFLAMMATORY PROCESSES IN RATS OF DIFFERENT AGE, AFFECTED BY TOBACCO SMOKE

  2017cites this paper
• Neuroimmunology of the Interleukins 13 and 4

  2016cites this paper
• La inducción de E2F1 y E2F2 en respuesta al daño al ADN preserva la estabilidad genómica en células neuronales

  2015cites this paper
• Neuroprotection of Stilbenes from Leaves of Cajanus cajan against Oxidative Damage Induced by Corticosterone and Glutamate in Differentiated PC12 Cells

  2015cites this paper
• Central inflammatory response to experimental stroke is inhibited by a neuroprotective dose of dietary soy.

  2014cites this paper
• Protective Effects of Astragaloside IV against Amyloid Beta1-42 Neurotoxicity by Inhibiting the Mitochondrial Permeability Transition Pore Opening

  2014cites this paper
• Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models

  2014cites this paper
• Inflammation and Programmed Cell Death in Alzheimer’s Disease: Comparison of the Central Nervous System and Peripheral Blood

  2014cites this paper
• Interleukin-13/Interleukin-4-induced oxidative stress contributes to death of prothrombinkringle-2 (pKr-2)-activated microglia.

  2013cites this paper
• Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus.

  2013cites this paper