Omega-[(omega-arylalkyl)aryl]alkanoic acids: a new class of specific LTA4 hydrolase inhibitors.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Journal of Medicinal Chemistry

• Publication date

  1992-08-21

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JM00095A010PMID 1324315
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril.

  1991cited by this paper
• Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes.

  1991cited by this paper
• Leukotriene A4 hydrolase: a zinc metalloenzyme.

  1990cited by this paper
• Molecular and cellular properties of human polymorphonuclear leukocyte receptors for leukotriene B4.

  1987cited by this paper
• Ebselen reduces the formation of LTB4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer.

  1986cited by this paper
• Neutrophil LTA4 hydrolases and leukotriene B4 receptors: effects of leukotriene epoxides and their enzymatic products.

  1986cited by this paper
• Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes.

  1985cited by this paper
• Leukotriene A3. A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase.

  1985cited by this paper
• Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease.

  1984cited by this paper
• Leukotriene B4‐like material in scale of psoriatic skin lesions

  1984cited by this paper
• Metabolism of arachidonic acid by human neutrophils. Characterization of the enzymatic reactions that lead to the synthesis of leukotriene B4.

  1984cited by this paper
• Characterization of the secretory activity of leukotriene B4 toward rabbit neutrophils.

  1982cited by this paper
• LEUKOTRIENE B4, AN INFLAMMATORY MEDIATOR IN GOUT

  1982cited by this paper
• Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence.

  1981cited by this paper
• Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

  1980cited by this paper
• Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

  1980cited by this paper

• Of rodents, research and relationships: a pharmacological odyssey

  2024cites this paper
• Deoxygenation in modern synthesis

  2019cites this paper
• Targeting leukotriene B4 in inflammation

  2014cites this paper
• Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.

  2011cites this paper
• Development of a Homogeneous Time-Resolved Fluorescence Leukotriene B4 Assay for Determining the Activity of Leukotriene A4 Hydrolase

  2007cites this paper
• Derivatives of 1,3-substituted diphenylpropane, preparations and uses

  2006cites this paper
• Leukotriene A4 Hydrolase/Aminopeptidase, the Gatekeeper of Chemotactic Leukotriene B4 Biosynthesis*

  2004cites this paper
• [Leukotriene-lipoxygenase pathway and drug discovery].

  2004cites this paper
• Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase I: in vitro studies.

  2002cites this paper
• Leukotriene A4 hydrolase.

  2002cites this paper
• Functional Properties and Molecular Architecture of Leukotriene A4 Hydrolase, a Pivotal Catalyst of Chemotactic Leukotriene Formation

  2002cites this paper
• Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies.

  2002cites this paper
• Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents.

  2001cites this paper
• Leukotriene A4 hydrolase : Identification of amino acid residues involved in catalyses and substrate-mediated inactivation

  2001cites this paper
• Identification of amino acid residues involved in catalyses and substrate-mediated inactivation

  2001cites this paper
• Structure, function, and regulation of leukotriene A4 hydrolase.

  2000cites this paper
• Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.

  2000cites this paper
• Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation

  1999cites this paper
• Leukotriene A 4 Hydrolase

  1998cites this paper
• 14,15-Dehydroleukotriene A4: a specific substrate for leukotriene C4 synthase.

  1997cites this paper
• The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors.

  1996cites this paper
• Cyclosporin A down-regulates the LTA4 hydrolase level in human keratinocyte cultures.

  1996cites this paper
• Alternate Functions for Aminopeptidases: Hydrolysis of Leukotriene A4

  1996cites this paper
• Leukotriene A4 Hydrolase: A Key Enzyme in the Biosynthesis of Leukotriene B4

  1996cites this paper
• Development of novel anti-inflammatory agents: a pharmacologic perspective on leukotrienes and their receptors.

  1996cites this paper
• Der Leukotriensignalweg – ein vielversprechender Ansatzpunkt für Inhibitoren in der Therapie entzündlicher Erkrankungen

  1995cites this paper
• [The leukotriene signal pathway--a very promising point of entry for inhibitors in therapy of inflammatory diseases].

  1995cites this paper
• Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase.

  1995cites this paper
• Inhibiteurs de l'hydrolase lta¿4?

  1995cites this paper
• Potent and selective inhibitors of leukotriene A4 hydrolase: effects on purified enzyme and human polymorphonuclear leukocytes.

  1995cites this paper
• 5-Lipoxygenase and 12-lipoxygenase: attractive targets for the development of novel antipsoriatic drugs.

  1994cites this paper
• 5‐Lipoxygenase and 12‐Lipoxygenase: Attractive Targets for the Development of Novel Antipsoriatic Drugs. 5‐Lipoxygenase und 12‐Lipoxygenase: Attraktive Target‐Enzyme für die Entwicklung neuer Antipsoriatika

  1994cites this paper
• Modulation of pulmonary leukotriene formation and perfusion pressure by bestatin, an inhibitor of leukotriene A4 hydrolase.

  1994cites this paper
• Synthesis and biological evaluation of new LTA4 analogs

  1994cites this paper
• Omega-[(omega-arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists.

  1992cites this paper