SUMOylation regulates telomere length homeostasis by targeting Cdc13

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Nature Structural &Molecular Biology

• Publication date

  2011-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nsmb.2100PMID 21743457PMCID PMC3291484
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast

  2011cited by this paper
• Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α

  2011cited by this paper
• De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks.

  2010cited by this paper
• CST meets shelterin to keep telomeres in check.

  2010cited by this paper
• Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.

  2009cited by this paper
• DNA damage signalling prevents deleterious telomere addition at DNA breaks

  2009cited by this paper
• Structural and functional insights into the roles of the Mms21 subunit of the Smc5/6 complex.

  2009cited by this paper
• Global map of SUMO function revealed by protein-protein interaction and genetic networks.

  2009cited by this paper
• Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13

  2009cited by this paper
• Sumoylation of the BLM ortholog, Sgs1, promotes telomere–telomere recombination in budding yeast

  2009cited by this paper
• A genome-wide screen for essential yeast genes that affect telomere length maintenance

  2009cited by this paper
• Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres.

  2009cited by this paper
• Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition

  2008cited by this paper
• How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex.

  2008cited by this paper
• Cooperation of Sumoylated Chromosomal Proteins in rDNA Maintenance

  2008cited by this paper
• The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins

  2007cited by this paper
• Topoisomerase I-Dependent Viability Loss in Saccharomyces cerevisiae Mutants Defective in Both SUMO Conjugation and DNA Repair

  2007cited by this paper
• The Slx5-Slx8 Complex Affects Sumoylation of DNA Repair Proteins and Negatively Regulates Recombination

  2007cited by this paper
• Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes.

  2007cited by this paper
• Role of SUMO in the dynamics of telomere maintenance in fission yeast

  2007cited by this paper
• Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p

  2006cited by this paper
• Regulation of telomere elongation by the cyclin-dependent kinase CDK1.

  2006cited by this paper
• Multiple domains in Siz SUMO ligases contribute to substrate selectivity

  2006cited by this paper
• Control of Rad52 recombination activity by double-strand break-induced SUMO modification

  2006cited by this paper
• Ku: a multifunctional protein involved in telomere maintenance.

  2005cited by this paper
• Defining the SUMO-modified Proteome by Multiple Approaches in Saccharomyces cerevisiae*

  2005cited by this paper
• A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.

  2005cited by this paper
• Protein modification by SUMO.

  2004cited by this paper
• Interaction of Saccharomyces Cdc13p with Pol1p, Imp4p, Sir4p and Zds2p is involved in telomere replication, telomere maintenance and cell growth control.

  2004cited by this paper
• Global Analysis of Protein Sumoylation in Saccharomyces cerevisiae*

  2004cited by this paper
• Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.

  2004cited by this paper
• Cell cycle-dependent regulation of yeast telomerase by Ku

  2004cited by this paper
• Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1.

  2004cited by this paper
• Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.

  2003cited by this paper
• Global analysis of protein expression in yeast

  2003cited by this paper
• Est1p As a Cell Cycle-Regulated Activator of Telomere-Bound Telomerase

  2002cited by this paper
• Cloning-free genome alterations in Saccharomyces cerevisiae using adaptamer-mediated PCR.

  2002cited by this paper
• The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1

  2002cited by this paper
• The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku

  2001cited by this paper
• Telomerase subunit overexpression suppresses telomere‐specific checkpoint activation in the yeast yku80 mutant

  2001cited by this paper
• An E3-like factor that promotes SUMO conjugation to the yeast septins.

  2001cited by this paper
• Cdc13 delivers separate complexes to the telomere for end protection and replication.

  2001cited by this paper
• Cdc13 both positively and negatively regulates telomere replication.

  2001cited by this paper
• Cdc13 Cooperates with the Yeast Ku Proteins and Stn1 To Regulate Telomerase Recruitment

  2000cited by this paper
• Cell cycle restriction of telomere elongation.

  2000cited by this paper
• Subtelomeric repeat amplification is associated with growth at elevated temperature in yku70 mutants of Saccharomyces cerevisiae.

  2000cited by this paper
• Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p.

  2000cited by this paper
• Two paralogs involved in transcriptional silencing that antagonistically control yeast life span.

  2000cited by this paper
• SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage.

  2000cited by this paper
• Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein.

  2000cited by this paper
• The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.

  2000cited by this paper
• Cell Cycle–Regulated Attachment of the Ubiquitin-Related Protein Sumo to the Yeast Septins

  1999cited by this paper
• Est1 and Cdc13 as comediators of telomerase access.

  1999cited by this paper
• Curing Saccharomyces cerevisiae of the 2 micron plasmid by targeted DNA damage

  1998cited by this paper
• Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.

  1997cited by this paper
• TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae

  1996cited by this paper
• Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast.

  1996cited by this paper
• Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase.

  1993cited by this paper
• Identification of yeast mutants with altered telomere structure.

  1986cited by this paper

• Dimerization of Cdc13 is essential for dynamic DNA exchange on telomeric DNA

  2025cites this paper
• STN1 Shields CTC1 From TRIM32‐Mediated Ubiquitination to Prevent Cellular Aging

  2025cites this paper
• SUMOylation regulation of ribosome biogenesis: Emerging roles for USP36.

  2024cites this paper
• Cdc13 exhibits dynamic DNA strand exchange in the presence of telomeric DNA

  2024cites this paper
• Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity

  2023cites this paper
• Control of telomere length in yeast by SUMOylated PCNA and the Elg1 PCNA unloader

  2023influential citation
• Cdc13 exhibits dynamic DNA strand exchange in the presence of telomeric DNA

  2023cites this paper
• CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension

  2023cites this paper
• Post-Transcriptional and Post-Translational Modifications in Telomerase Biogenesis and Recruitment to Telomeres

  2023cites this paper
• The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis

  2021cites this paper
• The Expression and Prognostic Value of SUMO1-Activating Enzyme Subunit 1 and Its Potential Mechanism in Triple-Negative Breast Cancer

  2021cites this paper
• Dynamic DNA Shortening by Telomere-Binding Protein Cdc13.

  2021cites this paper
• The Telomeric Cdc13 Protein from Yeast Hansenula polymorpha

  2020cites this paper
• Role of folding kinetics of secondary structures in telomeric G-overhangs in the regulation of telomere maintenance in Saccharomyces cerevisiae

  2020cites this paper
• SUMO E3 ligase CBX4 regulates hTERT-mediated transcription of CDH1 and promotes breast cancer cell migration and invasion.

  2020cites this paper
• Roles of OB-Fold Proteins in Replication Stress

  2020influential citation
• Structural insights into telomere protection and homeostasis regulation by yeast CST complex

  2020cites this paper
• Ssu72 phosphatase is a conserved telomere replication terminator

  2019cites this paper
• At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences

  2019cites this paper
• Characterizing the Role of SUMO in Transcriptional Repression in S. cerevisiae

  2019cites this paper
• Sumoylation of the DNA polymerase ε by the Smc5/6 complex contributes to DNA replication

  2019cites this paper
• Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating the Stn1-Ten1 complex in fission yeast

  2019cites this paper
• Telomere Formation Systems in Budding and Fission Yeasts

  2019cites this paper
• SSU72 phosphatase is a telomere replication terminator

  2018cites this paper
• Cis and trans interactions between genes encoding PAF1 complex and ESCRT machinery components in yeast

  2018cites this paper
• Nuclear import of Cdc13 limits chromosomal capping

  2018cites this paper
• Emerging roles of CST in maintaining genome stability and human disease.

  2018cites this paper
• Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance

  2018cites this paper
• SUMO and Chromatin Remodeling.

  2017cites this paper
• Genome maintenance in Saccharomyces cerevisiae: the role of SUMO and SUMO-targeted ubiquitin ligases

  2017influential citation
• The role of SUMOylation in ageing and senescent decline

  2017cites this paper
• Cell cycle–dependent spatial segregation of telomerase from sites of DNA damage

  2017influential citation
• Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction

  2017cites this paper
• Functions of SUMO in the Maintenance of Genome Stability.

  2017cites this paper
• Yeast genome-wide telomere screens and insights into cancer

  2017cites this paper
• Cell cycle–dependent spatial segregation of telomerase from sites of DNA damage

  2017influential citation
• Trafic intranucléaire de l’ARN de la télomérase et la réponse aux dommages à l’ADN chez la levure Saccharomyces cerevisiae

  2016influential citation
• Structure and function of the telomeric CST complex

  2016cites this paper
• Roles for SUMO in pre‐mRNA processing

  2016cites this paper
• Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators

  2016cites this paper
• Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases.

  2015influential citation
• Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes

  2015cites this paper
• Understanding the Roles of Telomeric Proteins in Telomere Length Regulation and Telomeric DNA Replication

  2015cites this paper
• SUMO-mediated regulation of DNA damage repair and responses.

  2015influential citation
• A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation

  2015cites this paper
• SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1Tpp1 to modulate shelterin–Stn1 interaction in fission yeast

  2014cites this paper
• Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association

  2014cites this paper
• The Molecular Interfaces of Telomerase and Telomere Proteins in Yeast and Humans

  2014cites this paper
• Subnuclear Architecture of Telomeres and Subtelomeres in Yeast

  2014influential citation
• conservation of SUMO-dependent Stn1 telomere association

  2014cites this paper
• Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association

  2014cites this paper
• At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1

  2014cites this paper
• Regulation of Ku-DNA Association by Yku70 C-terminal Tail and SUMO Modification*

  2014influential citation
• A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions

  2014influential citation
• Biology of telomeres: lessons from budding yeast.

  2014cites this paper
• OB Fold Contributes to Telomere Maintenance.

  2013cites this paper
• SUMO: a multifaceted modifier of chromatin structure and function.

  2013influential citation
• Chromatin Structure in Telomere Dynamics

  2013cites this paper
• SUMOylation of Rsp5p 1 of 19 SUMOylation regulates the Homologous to E6-AP Carboxy Terminus (HECT) ubiquitin ligase Rsp5p

  2013influential citation
• Cdc13 at a crossroads of telomerase action

  2013influential citation
• Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation.

  2013cites this paper
• SUMOylation Regulates the Homologous to E6-AP Carboxyl Terminus (HECT) Ubiquitin Ligase Rsp5p*

  2013cites this paper
• Is PCNA unloading the central function of the Elg1/ATAD5 replication factor C-like complex?

  2013cites this paper
• Replication of telomeres and the regulation of telomerase.

  2013cites this paper
• Control of nuclear activities by substrate-selective and protein-group SUMOylation.

  2013cites this paper
• Identification of novel factors controlling DNA damage responses at uncapped telomeres

  2013cites this paper
• A STUbL wards off telomere fusions

  2013cites this paper
• Telomere-end processing: mechanisms and regulation

  2013cites this paper
• Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance.

  2013cites this paper
• The functional role of SUMO E3 ligase Mms21p in the maintenance of subtelomeric silencing in budding yeast.

  2013cites this paper
• End‐joining inhibition at telomeres requires the translocase and polySUMO‐dependent ubiquitin ligase Uls1

  2013influential citation
• Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence.

  2013cites this paper
• Smc5/6 Coordinates Formation and Resolution of Joint Molecules with Chromosome Morphology to Ensure Meiotic Divisions

  2013cites this paper
• Simultaneous measurement of SUMOylation using SNAP/CLIP-tag-mediated translation at the single-molecule level.

  2013cites this paper
• Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End

  2012influential citation
• Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation

  2012cites this paper
• Sensitive detection of intracellular sumoylation via SNAP tag-mediated translation and RNA polymerase-based amplification.

  2012cites this paper
• Structure and Function in the Budding Yeast Nucleus

  2012cites this paper
• Posttranslational control of telomere maintenance and the telomere damage response

  2012cites this paper
• Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint.

  2012cites this paper
• SUMO Wrestles with Recombination

  2012cites this paper
• “Poisoning” yeast telomeres distinguishes between redundant telomere capping pathways

  2012cites this paper