Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Reproductive Toxicology

• Publication date

  2007-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.REPROTOX.2007.04.005PMID 17570632
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Dysmorphogenic Potential of Phenytoin: Experimental Observations

  2012cited by this paper
• Developmental toxicity of the class III antiarrhythmic agent almokalant in mice. Adverse effects mediated via induction of embryonic heart rhythm abnormalities.

  2011cited by this paper
• Embryotoxic effects of L-691,121, a class III antiarrhythmic agent, in rats

  2009cited by this paper
• Characterization of ventricular repolarization in male and female guinea pigs.

  2007cited by this paper
• New proposals for testing drugs with IKr-blocking activity to determine their teratogenic potential.

  2007cited by this paper
• Increased susceptibility to phenytoin teratogenicity: excessive generation of reactive oxygen species or impaired antioxidant defense?

  2006cited by this paper
• An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells.

  2005cited by this paper
• Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism.

  2005cited by this paper
• New concepts in reactive oxygen species and cardiovascular reperfusion physiology.

  2004cited by this paper
• Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development

  2004cited by this paper
• Teratogenicity by the hERG potassium channel blocking drug almokalant: use of hypoxia marker gives evidence for a hypoxia-related mechanism mediated via embryonic arrhythmia.

  2003cited by this paper
• Human Embryonic Stem Cells Develop Into Multiple Types of Cardiac Myocytes: Action Potential Characterization

  2003cited by this paper
• Phenytoin and phenobarbital inhibit human HERG potassium channels.

  2003cited by this paper
• Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia.

  2003cited by this paper
• Embryonic Arrhythmia by Inhibition of HERG Channels: A Common Hypoxia‐related Teratogenic Mechanism for Antiepileptic Drugs?

  2002cited by this paper
• Teratogenicity of the I(Kr)-blocker cisapride: relation to embryonic cardiac arrhythmia.

  2002cited by this paper
• Involvement of Mitochondria and Other Free Radical Sources in Normal and Abnormal Fetal Development

  2002cited by this paper
• Reactive species mechanisms of cellular hypoxia-reoxygenation injury.

  2002cited by this paper
• Stage-specific skeletal and visceral defects of the I(Kr)-blocker almokalant: further evidence for teratogenicity via a hypoxia-related mechanism.

  2001cited by this paper
• Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage.

  2001cited by this paper
• Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: A possible signal for vessel development

  2001cited by this paper
• Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development.

  2001cited by this paper
• Pharmacokinetic data support pharmacologically induced embryonic dysrhythmia as explanation to Fetal Hydantoin Syndrome in rats.

  2000cited by this paper
• Oxidative stress and cardiac disease.

  2000cited by this paper
• Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species.

  1999cited by this paper
• Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity

  1999cited by this paper
• Role of free radicals in the limb teratogenicity of L-NAME (N(G)-nitro-(L)-arginine methyl ester): a new mechanistic model of vascular disruption.

  1999cited by this paper
• Risk factors for sudden unexpected death in epilepsy: a case-control study.

  1999cited by this paper
• Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin.

  1999cited by this paper
• Direct measurement of oxygen free radicals during in utero hypoxia in the fetal guinea pig brain.

  1998cited by this paper
• Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs?

  1998cited by this paper
• Spatial distribution of glutathione, glutathione-related and antioxidant enzymes in cultured mouse embryos

  1997cited by this paper
• Arrhythmia, Heart Rate Variability, and Antiepileptic Drugs

  1997cited by this paper
• Antioxidant enzymatic activity in embryos and placenta of rats chronically exposed to hypoxia and hyperoxia.

  1997cited by this paper
• Initiation of phenytoin teratogenesis: pharmacologically induced embryonic bradycardia and arrhythmia resulting in hypoxia and possible free radical damage at reoxygenation.

  1997cited by this paper
• Cardiovascular Active Drugs

  1997cited by this paper
• Teratogenic potential of almokalant, dofetilide, and d-sotalol: drugs with potassium channel blocking activity.

  1996cited by this paper
• Developmental toxicity of ibutilide fumarate in rats after oral administration.

  1996cited by this paper
• Developmental changes in the delayed rectifier K+ channels in mouse heart.

  1996cited by this paper
• Reactive oxygen species in developmental toxicity: review and hypothesis.

  1996cited by this paper
• Developmental changes in ionic channel activity in the embryonic murine heart.

  1996cited by this paper
• Evidence for two components of delayed rectifier K+ current in human ventricular myocytes.

  1996cited by this paper
• Studies of mitochondria in oxidative embryotoxicity.

  1995cited by this paper
• A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.

  1995cited by this paper
• Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogenicity.

  1995cited by this paper
• Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.

  1995cited by this paper
• Role of oxygen free radicals in cocaine-induced vascular disruption in mice.

  1994cited by this paper
• Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant.

  1994cited by this paper
• Potassium channel blockers as antiarrhythmic drugs

  1994cited by this paper
• Effects of the class III antiarrhythmic, dofetilide (UK-68,798) on the heart rate of midgestation rat embryos, in vitro.

  1994cited by this paper
• Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations.

  1993cited by this paper
• Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide.

  1992cited by this paper
• Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity.

  1992cited by this paper
• Histopathological and hemodynamic studies supporting hypoxia and vascular disruption as explanation to phenytoin teratogenicity.

  1992cited by this paper
• Studies of the role of ischemia/reperfusion and superoxide anion radical production in the teratogenicity of cocaine.

  1992cited by this paper
• Development and growth in children of epileptic mothers: A prospective controlled study

  1991cited by this paper
• Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiologic and experimental findings spanning three decades; 1: Animal studies.

  1991cited by this paper
• Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiologic and experimental findings spanning three decades; 2: Human studies.

  1991cited by this paper
• Histological and in vitro studies supporting decreased uteroplacental blood flow as explanation for digital defects after administration of vasodilators.

  1990cited by this paper
• Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.

  1990cited by this paper
• Digital defects induced by vasodilating agents: relationship to reduction in uteroplacental blood flow.

  1989cited by this paper
• Cardiac Morphogenesis—Recent Research Advances

  1987cited by this paper
• Uterine trauma and limb defects.

  1987cited by this paper
• Morphogenesis of hypoxia-induced cleft lip in CL/Fr mice.

  1986cited by this paper
• Blebs and hematomas in the lips of CL/Fr and A/J mice.

  1985cited by this paper
• The role of dysrhythmic heart function during cardiovascular teratogenesis in epinephrine-treated chick embryos.

  1984cited by this paper
• Physiological and environmental determinants of phenytoin teratogenicity: relation to glutathione homeostasis, and potentiation by acetaminophen.

  1983cited by this paper
• Physiological and environmental determinants of phenytoin teratogenicity: relation to glutathione homeostasis, and potentiation by acetaminophen.

  1983cited by this paper
• Epilepsy, pregnancy, and the child

  1982cited by this paper
• Significance of the phenytoin reactive arene oxide intermediate its oxepin tautomer and clinical factors modifying their roles in phenytoin induced teratology

  1980cited by this paper
• Role of decreased cardiac output in isoproterenol-induced cardiovascular teratogenesis in chick embryos.

  1980cited by this paper
• Phenytoin-induced teratology and gingival pathology

  1980cited by this paper
• Cardiac arrhythmias after small iv dose of phenytoin.

  1976cited by this paper
• Cardiac arrhythmias after small iv dose of phenytoin.

  1976cited by this paper
• Carbamazepine for phantom-limb phenomena.

  1976cited by this paper
• Fetal hydantoin syndrome.

  1976cited by this paper
• The fetal hydantoin syndrome.

  1975cited by this paper
• Fetal pathology in rats following uterine-vessel clamping on day 14 of gestation.

  1974cited by this paper
• Studies on hypoxia--I. Gross and histologic influences of maternal anoxia upon the developing rat foetus.

  1968cited by this paper
• The development of the arterial outflow tract in the chick embryo heart

  1967cited by this paper
• Advances in teratology

  1966cited by this paper
• The effect of uterine vascular clamping on the development of rat embryos three to fourteen days old

  1964cited by this paper
• Uterine Vascular Clamping: New Procedure for the Study of Congenital Malformations

  1960cited by this paper
• Hypoxia at Normal Atmospheric Pressure As a Cause of Congenital Malformations in Mice.∗

  1957cited by this paper
• Principles governing the genesis of congenital malformations induced in mice by hypoxia.

  1957cited by this paper
• [Effect of short-term oxygen deficiency on development of chick embryo in the first five days of incubation].

  1953cited by this paper
• Experimental production of congenital anomalies; timing and degree of anoxia as factors causing fetal deaths and congenital anomalies in the mouse.

  1952cited by this paper

• The Effect of Some Complementary Medicine Active Components on Rat Embryonic Heart Rate In Vitro

  2026cites this paper
• Association of Commonly Prescribed Antepartum Medications and Incidence of Orofacial Clefting

  2024cites this paper
• Valproic Acid in Pregnancy Revisited: Neurobehavioral, Biochemical and Molecular Changes Affecting the Embryo and Fetus in Humans and in Animals: A Narrative Review

  2023cites this paper
• Teratogenicity and Reactive Oxygen Species after transient embryonic hypoxia: Experimental and clinical evidence with focus on drugs causing failed abortion in humans.

  2023influential citation
• Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study

  2020cites this paper
• Msx1 deficiency interacts with hypoxia and induces a morphogenetic regulation during lip development.

  2020cites this paper
• Study of the Effect of Prenatal Administration of Pregabalin on Cerebellar Cortex of Albino Rat's Offspring and the Possible Protective Role of Folic Acid

  2020cites this paper
• Adverse paediatric outcomes of macrolide antibiotics treatment in pregnancy

  2020cites this paper
• Placental transporter‐mediated drug interactions and offspring congenital anomalies

  2019cites this paper
• Ondansetron and teratogenicity in rats: Evidence for a mechanism mediated via embryonic hERG blockade.

  2018cites this paper
• Long‐term programming effects on blood pressure following gestational exposure to the I Kr blocker Dofetilide

  2018cites this paper
• Vitamin E as an Antioxidant in Female Reproductive Health

  2018cites this paper
• The Role of Biotransformation in Developmental Toxicity

  2018cites this paper
• Endocrine disruption, oxidative stress and lipometabolic disturbance of Bufo gargarizans embryos exposed to hexavalent chromium.

  2018cites this paper
• Curcuminbioavailability issues and its effect on birth defects

  2018cites this paper
• Early Gestational Hypoxia and Adverse Developmental Outcomes

  2017cites this paper
• Hypoplastic Left Heart Syndrome in a Patient with Fetal Hydantoin Syndrome

  2016cites this paper
• hERG1 potassium channel in cancer cells: a tool to reprogram immortality

  2016cites this paper
• KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation

  2016cites this paper
• N‐Chlorination rate of five‐membered heterocyclic nitrogen compounds

  2016cites this paper
• Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome,,

  2015cites this paper
• Effect of valproic acid administration during pregnancy on postnatal development of cerebellar cortex and the possible protective role of folic acid.

  2015cites this paper
• Association between Antibiotic Prescribing in Pregnancy and Cerebral Palsy or Epilepsy in Children Born at Term: A Cohort Study Using The Health Improvement Network

  2015cites this paper
• Cracking the Egg: Potential of the Developing Chicken as a Model System for Nonclinical Safety Studies of Pharmaceuticals

  2015cites this paper
• Curcumin affords protection against valproic acid induced teratogenicity by curtailing oxidative stress and inhibiting CYP2C9 activity

  2015cites this paper
• Developmental cardiotoxicity effects of four commonly used antiepileptic drugs in embryonic chick heart micromass culture and embryonic stem cell culture systems.

  2014cites this paper
• Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development.

  2014cites this paper
• Use of ondansetron during pregnancy and congenital malformations in the infant.

  2014cites this paper
• Excess ROS induced by AAPH causes myocardial hypertrophy in the developing chick embryo.

  2014cites this paper
• Effects of macrolide antibiotics on rat embryonic heart function in vitro.

  2014cites this paper
• Fetal safety of erythromycin. An update of Swedish data

  2014cites this paper
• Maternal toxicity.

  2013cites this paper
• Effect of reoxygenation on the electrical stability of the rat heart in vivo: a chronobiological study.

  2013cites this paper
• The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo.

  2013cites this paper
• Predictive value of cell assays for developmental toxicity and embryotoxicity of conazole fungicides.

  2013cites this paper
• hERG channel function: beyond long QT

  2013cites this paper
• Exploration of human, rat, and rabbit embryonic cardiomyocytes suggests K-channel block as a common teratogenic mechanism.

  2013cites this paper
• Methionine Enhances the Contractile Activity of Human Colon Circular Smooth Muscle In Vitro

  2012cites this paper
• Epilepsy drugs and effects on fetal development: Potential mechanisms

  2012cites this paper
• Chronobiological Aspects of the Heart Rhythm Disorders at the Change of Pulmonary Ventilation in Rat Model

  2012cites this paper
• The chick cardiomyocyte micromass system and stem cell differentiation along specific pathways : prediction of embryotoxic effects and their mechanism

  2012cites this paper
• ILSI/HESI maternal toxicity workshop summary: maternal toxicity and its impact on study design and data interpretation.

  2011cites this paper
• Differential contribution of mitochondria, NADPH oxidases, and glycolysis to region-specific oxidant stress in the anoxic-reoxygenated embryonic heart.

  2011cites this paper
• The effects of valproic acid and levetiracetam on chicken embryos.

  2011cites this paper
• Cyclophosphamide and the Teratology Society: an awkward marriage.

  2010cites this paper
• In Vivo Intervention Strategies : What Can They Tell Us ?

  2010cites this paper
• Developmental Toxicity of Antiepileptic Drugs

  2010cites this paper
• Animal Models of Autism: An Epigenetic and Environmental Viewpoint

  2010cites this paper
• ROLE OF THE HERG- CHANNEL IN ARRHYTHMIA AND TERATOGENICITY. STUDIES IN ANIMAL MODELS AND THE HUMAN EMBRYONIC HEART

  2010cites this paper
• 12.08 – The Role of Biotransformation in Developmental Toxicity

  2010cites this paper
• Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs.

  2010cites this paper
• The effect of human embryonic stem cells (hESCs) long-term normoxic and hypoxic cultures on the maintenance of pluripotency

  2010cites this paper
• Simultaneous gene expression signature of heart and peripheral blood mononuclear cells in astemizole-treated rats

  2010cites this paper
• 221 Cardiac Effects of Antiepileptic Drugs

  2010cites this paper
• Continuous hypoxic culturing maintains activation of Notch and allows long‐term propagation of human embryonic stem cells without spontaneous differentiation

  2009cites this paper
• Valproic acid in pregnancy: how much are we endangering the embryo and fetus?

  2009cites this paper
• In vitro and in vivo reproduction toxicology of 12 monoaminergic reuptake inhibitors: possible mechanisms of infrequent cardiovascular anomalies.

  2009cites this paper
• Acardiac fetus: evidence in support of a vascular/hypoxia pathogenesis for isolated oral clefting.

  2008cites this paper
• Register-based studies of delivery outcome after maternal use of some common drugs

  2008cites this paper
• The effect of hypoxia in development.

  2007cites this paper