Effects of KR-33028, a novel Na+/H+ exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Brain Research

• Publication date

  2009-01-12

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.brainres.2008.10.061PMID 19022230
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacodynamic characteristics and cardioprotective effects of new NHE1 inhibitors.

  2007cited by this paper
• Effects of KR‐33028, a novel Na+/H+ exchanger‐1 inhibitor, on ischemia and reperfusion‐induced myocardial infarction in rats and dogs

  2007cited by this paper
• Pharmacological profile of KR-33028, a highly selective inhibitor of Na+/H+ exchanger.

  2006cited by this paper
• Nefopam is more potent than carbamazepine for neuroprotection against veratridine in vitro and has anticonvulsant properties against both electrical and chemical stimulation

  2006cited by this paper
• KR-32570, a novel Na+/H+ exchanger-1 inhibitor, attenuates hypoxia-induced cell death through inhibition of intracellular Ca2+ overload and mitochondrial death pathway in H9c2 cells.

  2005cited by this paper
• Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.

  2005cited by this paper
• Decreased Neuronal Death in Na+/H+ Exchanger Isoform 1-Null Mice after In Vitro and In Vivo Ischemia

  2005cited by this paper
• Effects of prophylactic or therapeutic application of bovine haemoglobin HBOC-200 on ischaemia-reperfusion injury following acute coronary ligature in rats.

  2005cited by this paper
• Na+/H+ Exchanger Inhibitor, SM-20220, Is Protective Against Excitotoxicity in Cultured Cortical Neurons

  2004cited by this paper
• Na+/H+ Exchanger Inhibitor, SM-20220, Is Protective Against Excitotoxicity in Cultured Cortical Neurons

  2003cited by this paper
• Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion.

  2002cited by this paper
• A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons

  2001cited by this paper
• Protection of the ischaemic myocardium by Na+/H+ exchange inhibitors: potential mechanisms of action

  2001cited by this paper
• A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo.

  2001cited by this paper
• Glutamate as a neurotransmitter in the brain: review of physiology and pathology.

  2000cited by this paper
• Novel role of the Ca 2 1 -ATPase in NMDA-induced intracellular acidification

  1999cited by this paper
• Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1 cells.

  1999cited by this paper
• A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.

  1999cited by this paper
• Activation of neurotransmitter release in hippocampal nerve terminals during recovery from intracellular acidification.

  1999cited by this paper
• Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1cells.

  1999cited by this paper
• Novel role of the Ca2+-ATPase in NMDA-induced intracellular acidification.

  1999cited by this paper
• Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.

  1998cited by this paper
• Glutamate-induced neuron death requires mitochondrial calcium uptake

  1998cited by this paper
• Slowly triggered excitotoxicity occurs by necrosis in cortical cultures.

  1997cited by this paper
• Dissociation of effects of glutamate receptor antagonists on excitotoxic and hypoxic neuronal cell death in a novel rat cortical culture system.

  1997cited by this paper
• On the probabilistic nature of excitotoxic neuronal death in hippocampal neurons.

  1995cited by this paper
• Molecular diversity of glutamate receptors and implications for brain function.

  1992cited by this paper
• Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism.

  1992cited by this paper
• A New Model of Temporary Focal Neocortical Ischemia in the Rat

  1992cited by this paper
• Glutamate neurotoxicity and diseases of the nervous system.

  1988cited by this paper
• Ionic dependence of glutamate neurotoxicity

  1987cited by this paper
• Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay.

  1987cited by this paper
• A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction.

  1986cited by this paper
• Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

  1984cited by this paper

• Nutraceutical interventions for neuroprotection: a comprehensive review.

  2025cites this paper
• Significance of Neurotransmitters in Cerebral Ischemia: Understanding the Role of Serotonin, Dopamine, Glutamate, and GABA in Stroke Recovery and Treatment.

  2024cites this paper
• A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia

  2024cites this paper
• The Role of Plasma Membrane Sodium/Hydrogen Exchangers in Gastrointestinal Functions: Proliferation and Differentiation, Fluid/Electrolyte Transport and Barrier Integrity

  2022cites this paper
• novel approach towards eco-friendly green synthesis of copper nanoparticles from bunium persicum and their biomedical applications

  2022cites this paper
• The Kainic Acid Models of Temporal Lobe Epilepsy

  2021cites this paper
• Excitotoxicity as a Target against Neurodegenerative Processes.

  2020cites this paper
• Neurovascular unit transport responses to ischemia and common coexisting conditions: smoking and diabetes.

  2019cites this paper
• a Investigating sodium-hydrogen exchanger 1 (NHE1) inhibition as a potential therapy for Duchenne muscular dystrophy

  2018influential citation
• Sustained Intracellular Acidosis Triggers the Na+/H+ Exchager-1 Activation in Glutamate Excitotoxicity

  2017cites this paper
• Neurotransmitters in the mediation of cerebral ischemic injury

  2017cites this paper
• Antithrombotic activity of Vitis labrusca extract on rat platelet aggregation

  2016cites this paper
• KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells.

  2016cites this paper
• Excitatory Amino Acids Interaction and Neurotoxicity

  2016cites this paper
• Na(+)-H(+) exchanger inhibitor prevents early death in hereditary cardiomyopathy.

  2015cites this paper
• Chloroform fraction of Euphorbia maculata has antiplatelet activity via suppressing thromboxane B2 formation.

  2015cites this paper
• The role of blood-brain barrier transporters in pathophysiology and pharmacotherapy of stroke.

  2014cites this paper
• Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?

  2014cites this paper
• In vitro antiplatelet activity of silver nanoparticles synthesized using the microorganism Gluconobacter roseus: an AFM-based study

  2013cites this paper
• The Na(+)/H (+) exchanger NHE5 is sorted to discrete intracellular vesicles in the central and peripheral nervous systems.

  2013cites this paper
• The role of glutamate in neuronal ischemic injury: the role of spark in fire

  2012cites this paper
• Na+/H+ Exchangers as Therapeutic Targets for Cerebral Ischemia

  2012cites this paper
• Protective Effect of Grape Seed Extract against Oxidative Stress-Induced Cell Death in a Staurosporine-Differentiated Retinal Ganglion Cell Line

  2012cites this paper
• KR-33028, a Novel Na + /H + Exchanger-1 Inhibitor, Attenuates Glutamate-Induced Apoptotic Cell Death through Maintaining Mitochondrial Function

  2011cites this paper
• Mechanism of alkalosis-induced constriction of rat cerebral penetrating arterioles.

  2011cites this paper
• Antiplatelet effects of Cyperus rotundus and its component (+)-nootkatone.

  2011cites this paper
• Overexpression of the NHE1 isoform of the Na+/H+ exchanger causes elevated apoptosis in isolated cardiomyocytes after hypoxia/reoxygenation challenge

  2010cites this paper
• Glutamate Differently Modulates Metabotropic Glutamate Receptors in Neuronal and Glial Cells

  2010cites this paper
• Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

  2009cites this paper
• Efeitos da injeção intra-hipocampal de toxinas isoladas do veneno do escorpião Tityus bahiensis em ratos

  2009cites this paper