Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.

Xin A. Zhang,Xilin Zhou,R. Kisliuk,J. Piraino,V. Cody,A. Gangjee

Published 2011 in Bioorganic & Medicinal Chemistry

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