Exposing HIV's weaknesses

The viral restriction factor SERINC5 inhibits HIV-1 infection via unknown mechanisms. Sood and co-workers now show that SERINC5 suppresses HIV-1 fusogenicity and increases sensitivity to neutralizing antibodies by perturbing the folding of the fusion machinery. This work advances our understanding of host-virus interactions and provides a compelling case for considering the host immune system in studies of restriction factor mechanisms.

• Publication year

  2017

• Venue

  Journal of Biological Chemistry

• Publication date

  2017-04-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.H117.777714PMID 28389578PMCID PMC5392592
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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